{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:35:50Z","timestamp":1792427750430,"version":"4.5.0"},"reference-count":22,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T00:00:00Z","timestamp":1621468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Introduction<\/jats:title>\n<jats:p>In 2015, varicella vaccine was introduced to the National Immunization Programme in a one-dose regimen for infants aged 15 months. The aim of this study was to describe and compare the epidemiologic characteristics, management strategies and costs of varicella outbreaks in Ricardo Gutierrez Children\u2019s Hospital (HNRG) from 2000 to 2019, before (PreV period) and after (PostV period) the introduction of the varicella vaccine.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>A retrospective, analytic study of the impact of nosocomial varicella outbreaks at the HNRG, based on active epidemiologic surveillance. We compared nosocomial varicella outbreaks rates (per 10,000 discharges) between PreV and PostV, excluding the intervention year (2015).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>During PreV, an average of 15.87 (13.91\u201318.02) outbreaks per year was observed and in PostV 5.5 per year (3.44\u20138.32). Outbreaks adjusted by all cause discharges showed a reduction of 59.13% (-36.68%, -73.62%) after vaccine introduction.<\/jats:p>\n<jats:p>Considering that in PreV the average of susceptible cases per outbreak was 5.0 and in PostV 7.8, with a cost per susceptible of AR$\u2009$6,522 (80.27 USD) PreV and 6,708 PostV the economic impact on the reduction of outbreaks after the introduction of the vaccine, showed an estimated average savings per year of AR$ -252,128 AR$ (-3,103.11 USD).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The number of annual varicella hospital outbreaks at the HNRG decreased significantly after varicella vaccine was introduced to NIP in Argentina with a relevant reduction in terms of costs.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0251496","type":"journal-article","created":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T17:31:45Z","timestamp":1621531905000},"page":"e0251496","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impact of varicella vaccine on nosocomial outbreaks and management of post exposure prophylaxis following in a paediatric hospital"],"prefix":"10.1371","volume":"16","author":[{"given":"Angela","family":"Gentile","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norberto","family":"Giglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Florencia","family":"Lucion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Clara","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Pejito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria del Valle","family":"Juarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,5,20]]},"reference":[{"key":"pone.0251496.ref001","unstructured":"Mandell, Douglas, and Bennett\u00b4s. Principles and Practice of Infectious Diseases EIGHT EDITION ISBN 978-1-978-1-4557-4801-3 ELSEVIER SAUNDERS-Chickenpox and Herpes Zoster (Varicella-Zoster Virus) Richard J. Whitley pp 1731\u20131737."},{"key":"pone.0251496.ref002","unstructured":"Lineamientos T\u00e9cnicos. Fundamentos de la Introducci\u00f3n 2015 de Vacuna contra Varicela al Calendario Nacional de Inmunizaciones. Ministerio de Salud. Presidencia de la Nacion.Rep\u00fablica Argentina. http:\/\/www.msal.gob.ar\/images\/stories\/bes\/graficos\/0000000774cnt-2015-04_lineamientos-varicela.pdf [accessed 23 September 2020]."},{"issue":"268","key":"pone.0251496.ref003","first-page":"78","article-title":"Recommendations concerning exposure to chickenpox in hospital settings","volume":"60","author":"M Della Latta","year":"2018","journal-title":"Rev. Hosp. Ni\u00f1os (B. Aires)"},{"key":"pone.0251496.ref004","first-page":"869","volume-title":"Red Book 2018 Report of the Committee of Infectious Diseaes","author":"American Academy of Pediatrics Varicella Zoster Virus Infections Kimberlin DW","year":"2018","edition":"31"},{"key":"pone.0251496.ref005","unstructured":"Recomendaciones sobre control de la varicela para equipos de salud. Rep\u00fablica Argentina Presidencia de la Nacion. Rep\u00fablica Argentina hpp:\/\/www.msal.gob.ar\/images\/stories\/epidemiologia\/inmunizaciones\/equipos-de-salud\/recoemndaciones-varicela pp-7-12 [accessed 23 September 2020]."},{"key":"pone.0251496.ref006","unstructured":"Ministerio de Salud Argentino. Coberturas de Vacunaci\u00f3n por jurisdicci\u00f3n https:\/\/www.argentina.gob.ar\/salud\/inmunoprevenibles\/coberturas-de-vacunacion[accessed 25 February 2020]."},{"key":"pone.0251496.ref007","unstructured":"Dean AG, Sullivan KM, Soe MM. OpenEpi: Open Source Epidemiologic Statistics for Public Health, Versi\u00f3n. www.OpenEpi.com, updated 2013\/04\/06."},{"key":"pone.0251496.ref008"},{"issue":"10","key":"pone.0251496.ref009","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1097\/INF.0000000000000821","article-title":"Impact of the US Two-dose Varicella Vaccination Program on the Epidemiology of Varicella Outbreaks","volume":"34","author":"Jessica MPH Leung","year":"2015","journal-title":"The Pediatric Infectious Disease Journal"},{"issue":"Suppl 2","key":"pone.0251496.ref010","doi-asserted-by":"crossref","first-page":"S114","DOI":"10.1086\/522144","article-title":"Varicella outbreak epidemiology in an active surveillance site, 1995\u20132005","volume":"197","author":"R Civen","year":"2008","journal-title":"J Infect Dis"},{"key":"pone.0251496.ref011","volume-title":"Varicella vaccination in the European Union","author":"European Centre for Disease Prevention and Control","year":"2015"},{"issue":"1","key":"pone.0251496.ref012","first-page":"19","volume":"78","author":"D J Weber","year":"1988","journal-title":"Impact and Costs of Varicella Prevention in a University Hospital Am Journal Public Health"},{"key":"pone.0251496.ref013","first-page":"265","article-title":"Varicella and Herpes zoster Vaccine WHO position paper June 2013","volume":"89","author":"World Health Organization","year":"2014","journal-title":"Wkly Epidemiol Rec"},{"key":"pone.0251496.ref014","volume-title":"Residencia Post-b\u00e1sica de Epidemiolog\u00eda","author":"M Longordo Otero"},{"key":"pone.0251496.ref015","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1017\/S0195941700064936","article-title":"Susceptibility to Varicella zoster virus among adults at high risk exposure","volume":"7","author":"SJ Alter","year":"1986","journal-title":"Infect Control"},{"key":"pone.0251496.ref016","first-page":"3377","volume-title":"Mandell, Douglas, and Bennett\u2019s Principles and Practice of Infectious Diseases","author":"TN Palmore","year":"2015","edition":"8"},{"issue":"4","key":"pone.0251496.ref017","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1086\/512639","article-title":"Outbreak of varicella-zoster virus infection among Thai healthcare workers","volume":"28","author":"A Apisarnthanarak","year":"2007","journal-title":"Infect Control Hosp Epidemiol"},{"key":"pone.0251496.ref018","volume-title":"Surveillance standards for vaccine preventable diseases: varicella","author":"World Health Organization","year":"2018"},{"key":"pone.0251496.ref019","volume-title":"Health in the Americas+, 2017 edition. Summary: regional outlook and country profiles","author":"Pan American Health Organization","year":"2017"},{"issue":"4","key":"pone.0251496.ref020","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1080\/13696998.2018.1431919","article-title":"Economic burden of varicella in children 1\u201312 years of age in Argentina, 2009\u20132014","volume":"21","author":"N Giglio","year":"2018","journal-title":"J Med Econ"},{"issue":"3","key":"pone.0251496.ref021","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1093\/infdis\/jiq052","article-title":"Effectiveness of 2 doses of varicella vaccine in childrenExternal","volume":"203","author":"ED Shapiro","year":"2011","journal-title":"J Infect Dis"},{"issue":"Supl 2","key":"pone.0251496.ref022","first-page":"S37","article-title":"Comit\u00e9s y Grupos de Trabajo Actualizaci\u00f3n sobre vacunas: recomendaciones de 2018 Update on vaccines: 2018 recommendations","volume":"117","author":"Sociedad Argentina de Pediatr\u00eda Subcomisiones","year":"2019","journal-title":"Arch Argent Pediatr"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0251496","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T17:32:06Z","timestamp":1621531926000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0251496"}},"subtitle":[],"editor":[{"given":"Georges M.G.M.","family":"Verjans","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,5,20]]},"references-count":22,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,5,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0251496","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,20]]}}}