{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T08:08:16Z","timestamp":1774858096387,"version":"3.50.1"},"reference-count":19,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T00:00:00Z","timestamp":1620864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012352","name":"University of Milan","doi-asserted-by":"crossref","award":["APC initiative"],"award-info":[{"award-number":["APC initiative"]}],"id":[{"id":"10.13039\/100012352","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objective<\/jats:title>\n<jats:p>To describe the symptoms and clinical course of SARS-CoV-2 infection in patients with cystic fibrosis (CF).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>We carried out a prospective multicentre cohort study based on 32 CF centres and 6597 patients. Centres were contacted to collect baseline and follow-up data of patients who reported symptoms suggestive of COVID-19 or who had contact with a positive\/suspected case between the end of February and July 2020. Symptoms and clinical course of the infection were compared between patients who tested positive by molecular testing (cases) and those who tested negative (controls).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Thirty patients were reported from the centres, 16 of them tested positive and 14 tested negative. No differences in symptoms and outcome of the disease were observed between groups. Fever, cough, asthenia and dyspnea were the most frequently reported symptoms. Eight cases (50%) were hospitalized but none required ICU admission. Two adults with a history of lung transplant required non-invasive ventilation, none required ICU admission and all patients fully recovered without short-term sequelae.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The course of SARS-CoV-2 in our patients was relatively favorable. However, COVID-19 should not be considered a mild disease in CF patients, particularly for those with severely impaired respiratory function and organ transplant.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0251527","type":"journal-article","created":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T18:05:59Z","timestamp":1620929159000},"page":"e0251527","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":26,"title":["SARS-CoV-2 infection in cystic fibrosis: A multicentre prospective study with a control group, Italy, February-July 2020"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8975-695X","authenticated-orcid":true,"given":"Carla","family":"Colombo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianfranco","family":"Alicandro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Dacc\u00f3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Gagliano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Letizia 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Remuzzi","year":"2020","journal-title":"Lancet"},{"key":"pone.0251527.ref002","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1136\/thx.2010.157032","article-title":"Influenza A\/H1N1 in patients with cystic fibrosis in Italy: A multicentre cohort study","volume":"66","author":"C Colombo","year":"2011","journal-title":"Thorax"},{"key":"pone.0251527.ref003","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.jcf.2020.04.012","article-title":"A multinational report to characterise SARS-CoV-2 infection in people with cystic fibrosis","volume":"19","author":"R Cosgriff","year":"2020","journal-title":"J Cyst Fibros"},{"key":"pone.0251527.ref004","author":"Ministero della Salute","year":"2020","journal-title":"Monitoraggio settimanale Covid-19, report 20\u201326 luglio"},{"key":"pone.0251527.ref005","doi-asserted-by":"crossref","first-page":"106062","DOI":"10.1016\/j.rmed.2020.106062","article-title":"Impact of SARS-CoV-2 infection in patients with cystic fibrosis in 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