{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T03:38:47Z","timestamp":1767065927916,"version":"3.37.3"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T00:00:00Z","timestamp":1621468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81270043"],"award-info":[{"award-number":["81270043"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81573211"],"award-info":[{"award-number":["81573211"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Key S&T Special Projects on Major Infectious Diseases","award":["2018ZX10721102"],"award-info":[{"award-number":["2018ZX10721102"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["2019B1515120003"],"award-info":[{"award-number":["2019B1515120003"]}]},{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzhen","doi-asserted-by":"publisher","award":["SZSM201811071"],"award-info":[{"award-number":["SZSM201811071"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shenzhen Key Medical Discipline Construction Fund","award":["SZXK064"],"award-info":[{"award-number":["SZXK064"]}]},{"name":"Medical Scientific Research Foundation of Guangdong","award":["A2019474"],"award-info":[{"award-number":["A2019474"]}]},{"name":"Shenzhen Health System Research Project","award":["SZGW201810003"],"award-info":[{"award-number":["SZGW201810003"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objectives<\/jats:title>\n<jats:p>To analyze the trends of HIV\/syphilis\/HSV-2 seropositive rate and explore the related factors with HSV-2 infection to provide the basis for adjusting STD intervention strategies and formulating prevention and control measures among MSM in Shenzhen.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Time-location sampling was conducted among MSM in Shenzhen in 2012, 2014, 2016, and 2018. Data on demographics, sexual behaviors and the laboratory test results of HIV, syphilis, HSV-2 were collected. The \u03c7<jats:sup>2<\/jats:sup> trend test was used to analyze the trends of HIV\/syphilis\/HSV-2 seropositive rate. The binary logistic regression model was used to explore the factors associated with HSV-2 infection.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>The seropositive rate of HIV fell significantly from 15.9% in 2012 to 8.7% in 2018 (<jats:italic>P<\/jats:italic><jats:sub><jats:italic>trend<\/jats:italic><\/jats:sub> = 0.003), syphilis seropositive rate was significantly decreased from 20.4% in 2012 to 14.8% in 2018 (<jats:italic>P<\/jats:italic><jats:sub><jats:italic>trend<\/jats:italic><\/jats:sub> = 0.025), HSV-2 seropositive rate had no significant change (16.7% in 2012 to 14.0% in 2018; <jats:italic>P<\/jats:italic><jats:sub><jats:italic>trend<\/jats:italic><\/jats:sub> = 0.617). In principal component logistic regression analysis showed that FAC1_1 (X<jats:sub>1<\/jats:sub> = Ever had sex with female, X<jats:sub>2<\/jats:sub> = Gender of first sexual partner, X<jats:sub>3<\/jats:sub> = Marital status, X<jats:sub>4<\/jats:sub> = Age group), FAC2_1 (X<jats:sub>5<\/jats:sub> = Education, X<jats:sub>6<\/jats:sub> = Monthly income (RMB), X<jats:sub>7<\/jats:sub> = Frequency of condom use in anal sex with men in the past 6 months), and FAC4_1 (X<jats:sub>9<\/jats:sub> = History of STDs) were significantly associated with HSV-2 infection.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The seropositive rates of HIV and syphilis have dropped significantly but are still high. HSV-2 seropositive rate had no significant change and maintained a high level. It is necessary to continue strengthening HIV and syphilis interventions among MSM in Shenzhen. HSV-2 detection and intervention are urgently required for MSM, which might be another effective biological strategy further to control the HIV epidemic among MSM in Shenzhen.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0251929","type":"journal-article","created":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T17:46:28Z","timestamp":1621532788000},"page":"e0251929","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Trends of HIV\/Syphilis\/HSV-2 seropositive rate and factors associated with HSV-2 infection in men who have sex with men in Shenzhen, China: A retrospective 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