{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T13:14:51Z","timestamp":1769001291435,"version":"3.49.0"},"reference-count":48,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T00:00:00Z","timestamp":1621468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002509","name":"Keimyung University","doi-asserted-by":"publisher","award":["the Bisa Research Grant of Keimyung University in 2019"],"award-info":[{"award-number":["the Bisa Research Grant of Keimyung University in 2019"]}],"id":[{"id":"10.13039\/501100002509","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>This retrospective study aimed to evaluate the correlation between ophthalmologic factors and proteinuria in patients with pre-eclampsia using swept-source optical coherence tomography (OCT) and OCT angiography. In total, 61 pregnant patients diagnosed with pre-eclampsia were recruited during their hospital stay. The authors investigated the relationship between urine protein\u2013creatinine ratio (PCR) and chorioretinal measurements including choroidal thickness (CT), choroidal vascularity index (CVI), foveal avascular zone (FAZ), vascular density (VD), ganglion cell layer+ (GCL+) and GCL++. The associations between mean arterial pressure (MAP) and ophthalmologic factors were also evaluated. Central subfield CT of the right eye (<jats:italic>p<\/jats:italic> = 0.031) and paracentral CT of both eyes were related to higher PCR (\u22651.35 mg\/mg). A significant association with PCR after logarithm transformation was noted (<jats:italic>r<\/jats:italic> = 0.284, <jats:italic>p<\/jats:italic> = 0.026). Retinal measurements (FAZ, VD, GCL+ and GCL++) and CVI were not related with PCR. There was a positive association between MAP and PCR after logarithm transformation (<jats:italic>r<\/jats:italic> = 0.296, <jats:italic>p<\/jats:italic> = 0.021); however, chorioretinal factors were not related with MAP. In pregnant women with pre-eclampsia, CT using OCT is a novel factor that is correlated with PCR. Ocular structural alteration in patients with pre-eclampsia may be one of systemic vascular changes caused by pre-eclampsia rather than hypertension.<\/jats:p>","DOI":"10.1371\/journal.pone.0251933","type":"journal-article","created":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T17:43:14Z","timestamp":1621532594000},"page":"e0251933","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Relationship between proteinuria and optical coherence tomographic features of the chorioretina in patients with pre-eclampsia"],"prefix":"10.1371","volume":"16","author":[{"given":"Kyu Young","family":"Shim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Gon","family":"Bae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Kyoung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1615-6651","authenticated-orcid":true,"given":"Yu Cheol","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2021,5,20]]},"reference":[{"key":"pone.0251933.ref001","doi-asserted-by":"crossref","first-page":"5694235","DOI":"10.1155\/2017\/5694235","article-title":"Choroidal thickness in women with uncomplicated pregnancy: Literature review","volume":"2017","author":"J Roskal-Walek","year":"2017","journal-title":"Biomed Res Int"},{"key":"pone.0251933.ref002","first-page":"401","article-title":"Pregnancy and the eye","volume":"110","author":"A Kubicka-Trzaska","year":"2008","journal-title":"Klin Oczna"},{"key":"pone.0251933.ref003","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.ccl.2012.05.004","article-title":"Physiologic changes during normal pregnancy and delivery","volume":"30","author":"JG Ouzounian","year":"2012","journal-title":"Cardiol Clin"},{"key":"pone.0251933.ref004","doi-asserted-by":"crossref","first-page":"l2381","DOI":"10.1136\/bmj.l2381","article-title":"Pre-eclampsia: pathophysiology and clinical implications","volume":"366","author":"GJ Burton","year":"2019","journal-title":"BMJ"},{"key":"pone.0251933.ref005","first-page":"1122","article-title":"Gynecologists, Task Force on Hypertension in P. 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