{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:36:14Z","timestamp":1792841774675,"version":"4.5.0"},"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T00:00:00Z","timestamp":1622073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003921","name":"Department of Health, Australian Government","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>The burden of inflammatory bowel disease (IBD) in Australia is increasing but national data about the current prevalence are limited. We aimed to estimate the prevalence of IBD (including Crohn\u2019s disease, ulcerative colitis and unspecified IBD) as well as Crohn\u2019s disease and ulcerative colitis separately in a general practice population in Australia. We also assessed risk factors associated with Crohn\u2019s disease and ulcerative colitis. We conducted a cross-sectional study using data from MedicineInsight, a national database of general practice electronic health records, from 1 July 2017 to 30 June 2019. The prevalence of IBD was calculated and stratified by sociodemographic characteristics. Logistic regression analysis was conducted to assess risk factors associated with Crohn\u2019s disease and ulcerative colitis. The study comprised 2,428,461 regular patients from 481 practices. The estimated crude prevalence of IBD was 653 per 100,000 patients; Crohn\u2019s disease was 306 per 100,000 and ulcerative colitis was 334 per 100,000. Males were independently associated with a lower risk of Crohn\u2019s disease (OR: 0.86; 95% CI: 0.81, 0.90) but a greater risk of ulcerative colitis (OR: 1.12; 95% CI: 1.06, 1.17) than females. Compared to non-smokers, patients who were current smokers were associated with a greater risk of Crohn\u2019s disease (OR: 1.13; 95% CI: 1.04, 1.23) but a lower risk of ulcerative colitis (OR: 0.52; 95% CI: 0.47, 0.57). Other factors positively associated with both Crohn\u2019s disease and ulcerative colitis were age (\u2265 25 years), non-Indigenous status and socioeconomic advantage. Our findings provide a current estimate of the prevalence of IBD, Crohn\u2019s disease and ulcerative colitis in a large national general practice population in Australia and an assessment of the factors associated with Crohn\u2019s disease and ulcerative colitis. These data can assist in estimating the health burden and costs, and planning for health services.<\/jats:p>","DOI":"10.1371\/journal.pone.0252458","type":"journal-article","created":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T18:36:56Z","timestamp":1622140616000},"page":"e0252458","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":44,"title":["Prevalence of inflammatory bowel disease in the Australian general practice population: A cross-sectional study"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4744-9070","authenticated-orcid":true,"given":"Doreen","family":"Busingye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Pollack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendal","family":"Chidwick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,5,27]]},"reference":[{"issue":"9573","key":"pone.0252458.ref001","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1016\/S0140-6736(07)60750-8","article-title":"Inflammatory bowel disease: cause and immunobiology","volume":"369","author":"DC Baumgart","year":"2007","journal-title":"Lancet"},{"issue":"6","key":"pone.0252458.ref002","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00535-010-0219-3","article-title":"New pathophysiological insights and modern treatment of IBD","volume":"45","author":"MA Engel","year":"2010","journal-title":"J Gastroenterol"},{"issue":"1","key":"pone.0252458.ref003","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/jgh.12956","article-title":"Asia Pacific Consensus Statements on Crohn\u2019s disease. 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