{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:38:34Z","timestamp":1787618314903,"version":"build-2736575974"},"reference-count":60,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T00:00:00Z","timestamp":1623024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Center for Networked Biomedical Research in Neurodegenerative Diseases","award":["PI2014\/06"],"award-info":[{"award-number":["PI2014\/06"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Two new recurrence plot methods (the binary recurrence plot and binary cross recurrence plot) were introduced here to study the long-term dynamic of the primary motor cortex and its interaction with the primary somatosensory cortex, the anterior motor thalamus of the basal ganglia motor loop and the precuneous nucleus of the default mode network. These recurrence plot methods: 1. identify short-term transient interactions; 2. identify long-lasting delayed interactions that are common in complex systems; 3. work with non-stationary blood oxygen level dependent (BOLD) data; 4. may study the relationship of centers with non-linear functional interactions; 5 may compare different experimental groups performing different tasks. These methods were applied to BOLD time-series obtained in 20 control subjects and 20 Parkinson\u00b4s patients during the execution of motor activity and body posture tasks (task-block design). The binary recurrence plot showed the task-block BOLD response normally observed in the primary motor cortex with functional magnetic resonance imaging methods, but also shorter and longer BOLD-fluctuations than the task-block and which provided information about the long-term dynamic of this center. The binary cross recurrence plot showed short-lasting and long-lasting functional interactions between the primary motor cortex and the primary somatosensory cortex, anterior motor thalamus and precuneous nucleus, interactions which changed with the resting and motor tasks. Most of the interactions found in healthy controls were disrupted in Parkinson\u2019s patients, and may be at the basis of some of the motor disorders and side-effects of dopaminergic drugs commonly observed in these patients.<\/jats:p>","DOI":"10.1371\/journal.pone.0252565","type":"journal-article","created":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T17:26:18Z","timestamp":1623086778000},"page":"e0252565","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Studying the functional connectivity of the primary motor cortex with the binarized cross recurrence plot: The influence of Parkinson\u2019s disease"],"prefix":"10.1371","volume":"16","author":[{"given":"Clara","family":"Rodriguez-Sabate","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7569-2898","authenticated-orcid":true,"given":"Manuel","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Morales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,6,7]]},"reference":[{"issue":"1","key":"pone.0252565.ref001","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1080\/17588928.2018.1424128","article-title":"From goals to muscles: motor familiarity shapes the representation of action-related sounds in the human motor system","volume":"10","author":"LF Ticini","year":"2019","journal-title":"Cogn Neurosci"},{"key":"pone.0252565.ref002","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1146\/annurev-neuro-071013-013916","article-title":"Reassessing models of basal ganglia function and dysfunction","volume":"37","author":"AB Nelson","year":"2014","journal-title":"Annu Rev Neurosci"},{"issue":"1","key":"pone.0252565.ref003","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0165-0173(94)00007-C","article-title":"Functional anatomy of the basal ganglia. 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