{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T19:44:12Z","timestamp":1788378252987,"version":"build-2803163510"},"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T00:00:00Z","timestamp":1629158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Pfizer Pharmaceuticals Korea Ltd."}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Purpose<\/jats:title>\n<jats:p>Evaluation of symptoms and signs for the management of neuropathic cancer pain (NCP) is challenging. This study aimed to identify clinical predictors of NCP and symptoms and signs most relevant of those in Korean patients.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>This nationwide, descriptive, cross-sectional, multicenter, observational study included 2,003 cancer patients aged \u226520 years who reported a visual analog scale (VAS) score \u22651 for pain and provided informed consent for participation. The Douleur Neuropathic (DN4) questionnaire (score \u22654) was used to determine symptoms and signs as well as the presence of NCP.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>The prevalence of NCP was associated with age &lt;65 years [OR, 1.57; 95% CI, 1.270\u20131.934], disease duration &gt;6 months (OR, 1.57; 95% CI, 1.232\u20132.012), stage IV cancer (OR, 0.75; 95% CI, 0.593\u20130.955), history of chemotherapy (OR, 1.74; 95% CI, 1.225\u20132.472), and moderate-to-severe cancer pain (OR, 2.05; 95% CI, 1.671\u20132.524) after multivariate analysis. The most common descriptive symptoms of NCP were tingling, electric shock, and pins and needles. For NCP patients in the presence or absence of the clinical predictors, pins and needles (p = 0.001) and painful cold (p&lt;0.001) symptoms were significantly frequent in patients with moderate-to-severe pain. Tingling, numbness, and touch hypoesthesia (p = 0.022, 0.033, 0.024, respectively) were more frequent in those with longer cancer duration and hyperesthesia (p = 0.024) was more frequent in young patients.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Age &lt;65 years, disease duration &gt;6 months, stage IV cancer, history of chemotherapy, and moderate-to-severe cancer pain, were identified as predictors of NCP. Some symptoms and signs of NCP were associated with these predictors. Further studies are warranted on the pathogenesis and management of NCP with respect to the symptoms and signs, and factors associated with pain severity in Korean patients.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0252781","type":"journal-article","created":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T17:25:42Z","timestamp":1629221142000},"page":"e0252781","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Significance of descriptive symptoms and signs and clinical parameters as predictors of neuropathic cancer pain"],"prefix":"10.1371","volume":"16","author":[{"given":"Sun Kyung","family":"Baek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9182-1589","authenticated-orcid":true,"given":"Sang Won","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-Jin","family":"Koh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Han","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyo Jung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byoung Yong","family":"Shim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok Yun","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Byung","family":"Bae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwan Jung","family":"Yun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Jin","family":"Sym","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Sook","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ha Yeong","family":"Gil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,8,17]]},"reference":[{"issue":"1","key":"pone.0252781.ref001","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/j.pain.0000000000001363","article-title":"The IASP classification of chronic pain for ICD-11: chronic cancer-related pain","volume":"160","author":"MI Bennett","year":"2019","journal-title":"Pain"},{"issue":"2","key":"pone.0252781.ref002","doi-asserted-by":"crossref","first-page":"768","DOI":"10.4143\/crt.2015.087","article-title":"A Korean Nationwide Survey for Breakthrough Cancer Pain in an Inpatient Setting","volume":"48","author":"SK Baek","year":"2016","journal-title":"Cancer Res Treat"},{"issue":"8","key":"pone.0252781.ref003","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1016\/j.ejca.2009.01.007","article-title":"A systematic review on barriers hindering adequate cancer pain management and interventions to reduce them: a critical appraisal","volume":"45","author":"WH Oldenmenger","year":"2009","journal-title":"European journal of cancer (Oxford, England: 1990)"},{"issue":"8","key":"pone.0252781.ref004","first-page":"CD006146","article-title":"Opioids for neuropathic pain","author":"ED McNicol","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"issue":"3","key":"pone.0252781.ref005","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/papr.12459","article-title":"Pharmacological Treatment of Pain in Cancer Patients: The Role of Adjuvant Analgesics, a Systematic Review","volume":"17","author":"MH van den Beuken-van Everdingen","year":"2017","journal-title":"Pain Pract"},{"issue":"1","key":"pone.0252781.ref006","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/j.pain.0000000000001365","article-title":"The IASP classification of chronic pain for ICD-11: chronic neuropathic pain","volume":"160","author":"J Scholz","year":"2019","journal-title":"Pain"},{"issue":"2","key":"pone.0252781.ref007","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.ijrobp.2010.05.047","article-title":"Prevalence of neuropathic pain in radiotherapy oncology units","volume":"81","author":"A Manas","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"pone.0252781.ref008","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.pain.2011.10.028","article-title":"Prevalence and aetiology of neuropathic pain in cancer patients: a systematic review","volume":"153","author":"MI Bennett","year":"2012","journal-title":"Pain"},{"issue":"8","key":"pone.0252781.ref009","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1177\/0269216312464408","article-title":"Neuropathic cancer pain: prevalence, severity, analgesics and impact from the European Palliative Care Research Collaborative-Computerised Symptom Assessment study","volume":"27","author":"C Rayment","year":"2013","journal-title":"Palliat Med"},{"issue":"12","key":"pone.0252781.ref010","doi-asserted-by":"crossref","first-page":"3759","DOI":"10.1007\/s00520-017-3806-5","article-title":"Multicenter, cross-sectional observational study of the impact of neuropathic pain on quality of life in cancer patients","volume":"25","author":"SY Oh","year":"2017","journal-title":"Support Care Cancer"},{"issue":"2","key":"pone.0252781.ref011","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/papr.12732","article-title":"Chronic Pain in Breast Cancer Survivors: Nociceptive, Neuropathic, or Central Sensitization Pain?","volume":"19","author":"L Leysen","year":"2019","journal-title":"Pain Pract"},{"issue":"3","key":"pone.0252781.ref012","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11030373","article-title":"Cancer-Related Neuropathic Pain","volume":"11","author":"HL Edwards","year":"2019","journal-title":"Cancers"},{"issue":"2","key":"pone.0252781.ref013","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.ygyno.2018.12.002","article-title":"A longitudinal examination of associations between age and chemotherapy-induced peripheral neuropathy in patients with gynecologic cancer","volume":"152","author":"HW Bulls","year":"2019","journal-title":"Gynecol Oncol"},{"issue":"6","key":"pone.0252781.ref014","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.jpainsymman.2014.11.300","article-title":"Neuropathic Symptoms and Their Risk Factors in Medical Oncology Outpatients With Colorectal vs. Breast, Lung, or Prostate Cancer: Results From a Prospective Multicenter Study","volume":"49","author":"MA Lewis","year":"2015","journal-title":"J Pain Symptom Manage"},{"issue":"12","key":"pone.0252781.ref015","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/nrneurol.2010.160","article-title":"Chemotherapy-induced peripheral neurotoxicity","volume":"6","author":"G Cavaletti","year":"2010","journal-title":"Nat Rev Neurol"},{"issue":"2","key":"pone.0252781.ref016","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.jpainsymman.2017.08.028","article-title":"Cancer Pain With a Neuropathic Component: A Cross-sectional Study of Its Clinical Characteristics, Associated Psychological Distress, Treatments, and Predictors at Referral to a Cancer Pain Clinic","volume":"55","author":"P Reis-Pina","year":"2018","journal-title":"J Pain Symptom Manage"},{"issue":"16","key":"pone.0252781.ref017","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1200\/JCO.2013.52.4629","article-title":"Pain in cancer survivors","volume":"32","author":"PA Glare","year":"2014","journal-title":"J Clin Oncol"},{"issue":"2\u20133","key":"pone.0252781.ref018","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0304-3959(96)03064-3","article-title":"Pain after breast surgery: a survey of 282 women","volume":"66","author":"MS Wallace","year":"1996","journal-title":"Pain"},{"issue":"1","key":"pone.0252781.ref019","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.critrevonc.2011.04.012","article-title":"Chemotherapy-induced peripheral neurotoxicity (CIPN): an update","volume":"82","author":"AA Argyriou","year":"2012","journal-title":"Critical reviews in oncology\/hematology"},{"issue":"4","key":"pone.0252781.ref020","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1634\/theoncologist.2014-0044","article-title":"Platinum-induced neurotoxicity and preventive strategies: past, present, and future","volume":"20","author":"A Avan","year":"2015","journal-title":"The oncologist"},{"issue":"4","key":"pone.0252781.ref021","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1093\/annonc\/mdq449","article-title":"First evidence of oncologic neuropathic pain prevalence after screening 8615 cancer patients. Results of the On study","volume":"22","author":"ML Garcia de Paredes","year":"2011","journal-title":"Annals of oncology: official journal of the European Society for Medical Oncology"},{"issue":"2","key":"pone.0252781.ref022","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1080\/15360280902900489","article-title":"Prevalence, etiology, and management of neuropathic pain in an Indian cancer hospital","volume":"23","author":"PN Jain","year":"2009","journal-title":"J Pain Palliat Care Pharmacother"},{"issue":"10","key":"pone.0252781.ref023","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1185\/030079906X132488","article-title":"painDETECT: a new screening questionnaire to identify neuropathic components in patients with back pain","volume":"22","author":"R Freynhagen","year":"2006","journal-title":"Curr Med Res Opin"},{"issue":"1\u20132","key":"pone.0252781.ref024","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0304-3959(00)00482-6","article-title":"The LANSS Pain Scale: the Leeds assessment of neuropathic symptoms and signs","volume":"92","author":"M Bennett","year":"2001","journal-title":"Pain"},{"issue":"1\u20132","key":"pone.0252781.ref025","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.pain.2004.12.010","article-title":"Comparison of pain syndromes associated with nervous or somatic lesions and development of a new neuropathic pain diagnostic questionnaire (DN4)","volume":"114","author":"D Bouhassira","year":"2005","journal-title":"Pain"},{"issue":"6","key":"pone.0252781.ref026","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1002\/ejp.598","article-title":"Prevalence of pain and relative diagnostic performance of screening tools for neuropathic pain in cancer patients: A cross-sectional study","volume":"19","author":"C Perez","year":"2015","journal-title":"Eur J Pain"},{"issue":"1","key":"pone.0252781.ref027","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/PL00007853","article-title":"Chemotherapy-induced peripheral neuropathy","volume":"249","author":"S Quasthoff","year":"2002","journal-title":"J Neurol"},{"issue":"4","key":"pone.0252781.ref028","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/papr.12291","article-title":"Neuropathic Pain Components in Patients with Cancer: Prevalence, Treatment, and Interference with Daily Activities","volume":"16","author":"A Oosterling","year":"2016","journal-title":"Pain Pract"},{"issue":"3","key":"pone.0252781.ref029","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1177\/0269216311402711","article-title":"Meta-analysis of cultural differences in Western and Asian patient-perceived barriers to managing cancer pain","volume":"26","author":"CH Chen","year":"2012","journal-title":"Palliat Med"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0252781","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T17:26:20Z","timestamp":1629221180000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0252781"}},"subtitle":[],"editor":[{"given":"Ahmed","family":"Negida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,8,17]]},"references-count":29,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2021,8,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0252781","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,17]]}}}