{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:01:23Z","timestamp":1789470083424,"version":"build-2803163510"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T00:00:00Z","timestamp":1623283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"crossref","award":["NRF-2019R1G1A1085289"],"award-info":[{"award-number":["NRF-2019R1G1A1085289"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002380","name":"Hanyang University","doi-asserted-by":"publisher","award":["HY-201900000003370"],"award-info":[{"award-number":["HY-201900000003370"]}],"id":[{"id":"10.13039\/501100002380","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background and purpose<\/jats:title>\n<jats:p>Peritumoral brain edema (PTBE) is a common complication in meningioma and disruption of the tumor-brain barrier in meningioma is crucial for PTBE formation. To evaluate the association between meningioma size and PTBE, we measured meningioma volumes using the 3D slicer in patients with convexity and parasagittal meningiomas.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Receiver operating characteristic curve analysis was used to determine the optimal cut-off meningioma volume values for predicting PTBE occurrence. Logistic regressions were used to estimate the odds ratios for PTBE occurrence in patients with convexity and parasagittal meningiomas according to several predictive factors.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>A total of 205 convexity or parasagittal meningioma patients with no other brain disease who underwent one or more contrast-enhanced brain MRIs were enrolled in this 10-year analysis in two hospitals. The optimal cut-off meningioma volume value for prediction of PTBE in all study patients was 13.953 cc (sensitivity = 76.1%; specificity = 92.5%). If a meningioma is assumed to be a complete sphere, 13.953 cc is about 2.987 cm in diameter.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Our study suggests a cut-off value of 3 cm meningioma diameter for prediction of PTBE in patients with convexity and parasagittal meningiomas. We believe that we have revealed why the meningioma diameter of 3 cm is clinically meaningful.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0252945","type":"journal-article","created":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T23:43:34Z","timestamp":1623368614000},"page":"e0252945","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":25,"title":["Association between tumor size and peritumoral brain edema in patients with convexity and parasagittal meningiomas"],"prefix":"10.1371","volume":"16","author":[{"given":"Chansub","family":"Shin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Min","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0022-312X","authenticated-orcid":true,"given":"Jin Hwan","family":"Cheong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Je Il","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Deok","family":"Won","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1728-5017","authenticated-orcid":true,"given":"Myung-Hoon","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,6,10]]},"reference":[{"key":"pone.0252945.ref001","doi-asserted-by":"crossref","first-page":"E2","DOI":"10.3171\/2013.8.FOCUS13301","article-title":"Peritumoral brain edema in intracranial meningiomas: the emergence of vascular endothelial growth factor-directed therapy","volume":"35","author":"J Hou","year":"2013","journal-title":"Neurosurg Focus"},{"key":"pone.0252945.ref002","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1002\/(SICI)1097-0142(19990215)85:4<936::AID-CNCR23>3.0.CO;2-J","article-title":"Peritumoral brain edema associated with meningioma","volume":"85","author":"H Yoshioka","year":"1999","journal-title":"Cancer"},{"key":"pone.0252945.ref003","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.surneu.2008.03.006","article-title":"Peritumoral brain edema in benign meningiomas: correlation with clinical, radiologic, and surgical factors and possible role on recurrence","volume":"70","author":"A Simis","year":"2008","journal-title":"Surg Neurol"},{"key":"pone.0252945.ref004","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3340\/jkns.2011.49.1.26","article-title":"Peritumoral Brain Edema in Meningiomas: Correlation of Radiologic and Pathologic Features.","volume":"49","author":"B-W Kim","year":"2011","journal-title":"J Korean Neurosurg Soc"},{"key":"pone.0252945.ref005","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1023\/A:1021186401522","article-title":"Correlation of clinical and biological parameters with peritumoral edema in meningioma","volume":"60","author":"SH Paek","year":"2002","journal-title":"J Neurooncol"},{"key":"pone.0252945.ref006","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1227\/00006123-199208000-00002","article-title":"Peritumoral brain edema in meningiomas\u2014influence of vascular supply on its development","volume":"31","author":"T Inamura","year":"1992","journal-title":"Neurosurgery"},{"key":"pone.0252945.ref007","article-title":"Significance of skull osteoporosis to the development of peritumoral brain edema after LINAC-based radiation treatment in patients with intracranial meningioma","volume":"15","author":"R-H Lee","year":"2020","journal-title":"PLoS ONE"},{"key":"pone.0252945.ref008","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1227\/01.NEU.0000365366.53337.88","article-title":"Principal Risk of Peritumoral Edema After Stereotactic Radiosurgery for Intracranial Meningioma Is Tumor-Brain Contact Interface Area","volume":"66","author":"R Cai","year":"2010","journal-title":"Neurosurgery"},{"key":"pone.0252945.ref009","doi-asserted-by":"crossref","first-page":"627","DOI":"10.2176\/nmc.oa.2017-0115","article-title":"CyberKnife Stereotactic Radiosurgery and Hypofractionated Stereotactic Radiotherapy As First-line Treatments for Imaging-diagnosed Intracranial Meningiomas","volume":"57","author":"Y Manabe","year":"2017","journal-title":"Neurol Med Chir (Tokyo)."},{"key":"pone.0252945.ref010","doi-asserted-by":"crossref","first-page":"e0124534","DOI":"10.1371\/journal.pone.0124534","article-title":"Is Postoperative Imaging Mandatory after Meningioma Removal? 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