{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T18:32:17Z","timestamp":1774549937056,"version":"3.50.1"},"reference-count":18,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T00:00:00Z","timestamp":1624406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18K18411"],"award-info":[{"award-number":["18K18411"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP18H05470"],"award-info":[{"award-number":["JP18H05470"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"name":"T-CReDO, Tsukuba Clinical Research & Development Organization","award":["A17-83"],"award-info":[{"award-number":["A17-83"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>The current method of controlling the focus of an accommodating intraocular lens is based on ciliary muscle contraction and cannot be used in older patients with presbyopia. We aimed to develop a dynamically accommodating intraocular lens powered by a membrane-shaped ion polymer metal composite actuator that is thin enough to be inserted in the eye. This study addresses two key problems identified in our previous accommodating intraocular lens prototype: the lack of repeatability due to the use of swine lenses instead of artificial lenses and the occurrence of a sixth order aberration. Thus, we present a new accommodating intraocular lens design and a method to transfer energy to actuators. To accommodate lens deformation and depth of focus, we used a membrane-shaped ion polymer metal composite actuator, thin enough to be inserted in the eye, and used an artificial silicone lens. To prevent the sixth order aberration, we included a ring between the ion polymer metal composite actuator and the lens. Different voltage patterns were applied to the IPMC actuator and changes in focus were observed. We were able to obtain repeatability and prevent the sixth order aberration. The dioptric power changed to \u00b10.23 D when \u00b11.5 V was used; however, at &gt;1.5 V, a large accommodating range occurred, in addition to astigmatic vision. Thus, we have developed a novel prototype that is completely artificial, allowing reproducible and repeatable results. Visual accommodative demands were successfully met; however, although astigmatic vision was lessened, it was not completely eradicated.<\/jats:p>","DOI":"10.1371\/journal.pone.0252986","type":"journal-article","created":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T17:37:39Z","timestamp":1624469859000},"page":"e0252986","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Artificial accommodating intraocular lens powered by an ion polymer-metal composite actuator"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9349-7874","authenticated-orcid":true,"given":"Tetsuya","family":"Horiuchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshifumi","family":"Mihashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sujin","family":"Hoshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumiki","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9071-7018","authenticated-orcid":true,"given":"Tetsuro","family":"Oshika","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2021,6,23]]},"reference":[{"key":"pone.0252986.ref001","unstructured":"World Health Organization. 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Variable-focal length lens using IPMC. 2009 ICCAS-SICE, Fukuoka, Japan, 2009, pp. 4752\u20134756."},{"issue":"4","key":"pone.0252986.ref015","doi-asserted-by":"crossref","first-page":"5021","DOI":"10.1088\/1361-665X\/aa61e8","article-title":"Voltage-controlled IPMC actuators for accommodating intra-ocular lens systems","volume":"26","author":"T Horiuchi","year":"2017","journal-title":"Smart Mater. Struct"},{"issue":"1","key":"pone.0252986.ref016","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jcrs.2012.08.052","article-title":"Design and validity of a miniaturized open-field aberrometer","volume":"39","author":"UK Bhatt","year":"2013","journal-title":"J. Cataract Refract. 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