{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:15:41Z","timestamp":1747196141250,"version":"3.40.5"},"reference-count":26,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T00:00:00Z","timestamp":1628121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objectives<\/jats:title>\n<jats:p>Many studies have investigated the surgical outcome and predictive factors of acoustic neuroma using different approaches. The present study focused on large tumors due to the greater likelihood of internal acoustic meatus involvement and the greater application of surgical intervention than radiosurgery. There have been no previous reports on outcomes of internal acoustic meatus tumor removal. We investigated the impact of the extent of internal acoustic meatus tumor removal using a translabyrinthine approach for large acoustic neuroma surgery and predictive factors of tumor control.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>This retrospective study reviewed 104 patients with large cerebellopontine angle tumor &gt;3 cm treated by translabyrinthine approach microsurgery. Predictive factors of postoperative facial palsy, tumor control, and extent of internal acoustic meatus tumor removal were assessed.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>The mean tumor size was 38.95 \u00b1 6.83 mm. Postoperative facial function showed 76.9% acceptable function (House\u2013Brackmann grade 1 or 2) six months after surgery. The extent of internal acoustic meatus tumor removal was a statistically significant predictor factor of poor postoperative facial function. Younger age, larger tumor size needing radiosurgery, and more extensive removal of tumor were associated with better tumor control.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>More extensive internal acoustic meatus tumor removal was associated with poor postoperative facial function and better tumor control.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0253338","type":"journal-article","created":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T17:51:39Z","timestamp":1628185899000},"page":"e0253338","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of extent of internal acoustic meatus tumor removal using translabyrinthine approach for acoustic neuroma surgery"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6888-3589","authenticated-orcid":true,"given":"Kuan-Wei","family":"Chiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanford P. C.","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsui-Fen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7168-5196","authenticated-orcid":true,"given":"Mao-Che","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2021,8,5]]},"reference":[{"issue":"2","key":"pone.0253338.ref001","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.otc.2011.12.009","article-title":"Translabyrinthine approach: indications, techniques, and results","volume":"45","author":"M.A. Arriaga","year":"2012","journal-title":"Otolaryngol Clin North Am"},{"key":"pone.0253338.ref002","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0385-8146(00)00057-2","article-title":"Translabyrinthine removal of large acoustic neuromas in young adults","volume":"27","author":"Wu a Hao","year":"2000","journal-title":"Auris Nasus Larynx"},{"key":"pone.0253338.ref003","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1054\/jocn.2000.0728","article-title":"Current management of acoustic neuromas: review of surgical approaches and outcomes","volume":"7","author":"J Robert","year":"2000","journal-title":"Journal of Clinical Neuroscience"},{"issue":"2","key":"pone.0253338.ref004","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1227\/NEU.0000000000001162","article-title":"Facial Nerve Outcome and Tumor Control Rate as a Function of Degree of Resection in Treatment of Large Acoustic Neuromas: Preliminary Report of the Acoustic Neuroma Subtotal Resection Study (ANSRS)","volume":"79","author":"Ashkan Monfared","year":"2016","journal-title":"Neurosurgery"},{"issue":"6","key":"pone.0253338.ref005","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1080\/00016489.2019.1592223","article-title":"Prognostic factors of facial nerve function after vestibular schwannoma removal via translabyrinthine approach","volume":"139","author":"Jungmin Ahn","year":"2019","journal-title":"Acta Oto-Laryngologica"},{"key":"pone.0253338.ref006","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3171\/jns.1997.87.1.0060","article-title":"Facial nerve injury in acoustic neuroma (vestibular schwannoma)","volume":"87","author":"Prakash Sampath","year":"1997","journal-title":"J. Neurosurg"},{"key":"pone.0253338.ref007","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3171\/jns.2001.94.2.0217","article-title":"Cerebrospinal fluid leak after acoustic neuroma surgery influence of tumor size and surgical approach on incidence and response to treatment","author":"Jeffery W. Brennan","year":"2001","journal-title":"J Neurosurg"},{"issue":"2","key":"pone.0253338.ref008","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1097\/MAO.0000000000001267","article-title":"Can the Risks of Cerebrospinal Fluid Leak After Vestibular Schwannoma Surgery Be Predicted?","volume":"38","author":"A. 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Zanoletti","year":"2016","journal-title":"Rep Pract Oncol Radiother"},{"key":"pone.0253338.ref014","article-title":"Tumors of the nervus acusticus and the syndrome of the cerebellopontine angle","author":"M.D. Harvey Cushing","year":"1918","journal-title":"Laryngoscope"},{"issue":"6","key":"pone.0253338.ref015","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1177\/019459980112400609","article-title":"Long-term results of the first 500 cases of acoustic neuroma surgery","volume":"124","author":"RJ Wiet","year":"2001","journal-title":"Otolaryngology\u2014Head and Neck Surgery"},{"key":"pone.0253338.ref016","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1097\/00129492-200203000-00020","article-title":"Translabyrinthine approach for the management of large and giant vestibular schwannomas","volume":"23","author":"R.J.W. Bulent Mamikoglu","year":"2002","journal-title":"Otology & Neurotology"},{"issue":"11","key":"pone.0253338.ref017","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.3109\/00016481003762316","article-title":"Perioperative complications after translabyrinthine removal of large or giant vestibular schwannoma: Outcomes for 123 patients","volume":"130","author":"A Charpiot","year":"2010","journal-title":"Acta Otolaryngol"},{"key":"pone.0253338.ref018","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1177\/000348940411300412","article-title":"Enlarged translabyrinthine approach for the management of large and giant acoustic neuromas a report of 175 consecutive cases","volume":"113","author":"M.A.R. 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R.N.P.-H Roche","year":"2008","journal-title":"Prog Neurol Surg"},{"issue":"2","key":"pone.0253338.ref022","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1097\/MAO.0000000000002068","article-title":"Facial Nerve Outcomes Following Total Excision of Vestibular Schwannoma by the Enlarged Translabyrinthine Approach","volume":"40","author":"M. Dandinarasaiah","year":"2019","journal-title":"Otol Neurotol"},{"issue":"4","key":"pone.0253338.ref023","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0090-3019(03)00025-9","article-title":"Surgery combined with radiosurgery of large acoustic neuromas","volume":"59","author":"Y. 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