{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T06:49:43Z","timestamp":1768805383268,"version":"3.49.0"},"reference-count":64,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T00:00:00Z","timestamp":1623974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["16GE-040"],"award-info":[{"award-number":["16GE-040"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007029","name":"State Committee of Science","doi-asserted-by":"publisher","award":["16GE-040; 19YR-1F045; 20TTCG-1F003"],"award-info":[{"award-number":["16GE-040; 19YR-1F045; 20TTCG-1F003"]}],"id":[{"id":"10.13039\/501100007029","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>For the last years, copper complexes have been intensively implicated in biomedical research as components of cancer treatment. Herewith, we provide highlights of the synthesis, physical measurements, structural characterization of the newly developed Cu(II) chelates of Schiff Bases, Cu(Picolinyl-L-Tryptopahanate)<jats:sub>2<\/jats:sub>, Cu(Picolinyl-L-Tyrosinate)<jats:sub>2<\/jats:sub>, Cu(Isonicotinyl-L-Tyrosinate)<jats:sub>2<\/jats:sub>, Cu(Picolinyl-L-Phenylalaninate)<jats:sub>2<\/jats:sub>, Cu(Nicotinyl-L-Phenylalaninate)<jats:sub>2<\/jats:sub>, Cu(Isonicotinyl-L-Phenylalaninate)<jats:sub>2<\/jats:sub>, and their radioenhancement capacity at kV and MV ranges of irradiation of human lung carcinoma epithelial cells <jats:italic>in vitro<\/jats:italic>. The methods of cell growth, viability and proliferation were used. All compounds exerted very potent radioenhancer capacities in the irradiated lung carcinoma cells at both kV and MV ranges in a 100 \u03bcM concentration. At a concentration of 10 \u03bcM, only Cu(Picolinyl-L-Tyrosinate)<jats:sub>2<\/jats:sub>, Cu(Isonicotinyl-L-Tyrosinate)<jats:sub>2<\/jats:sub>, Cu(Picolinyl-L-Phenylalaninate)<jats:sub>2<\/jats:sub> possessed radioenhancer properties at kV and MV ranges. Cu(Picolinyl-L-Tryptophanate)<jats:sub>2<\/jats:sub> showed radioenhancer properties only at kV range. Cu(Nicotinyl-L-Phenylalaninate)<jats:sub>2<\/jats:sub> and Cu(Isonicotinyl-L-Phenylalaninate)<jats:sub>2<\/jats:sub> showed remarkable radioenhancer activity only at MV range. All compounds acted in dose-dependent manner at both tested energy ranges. These copper (II) compounds, in combination with 1 Gy irradiation at either 120 kV or 6 MV, are more efficient at delaying cell growth of lung cancer cells and at reducing cell viability <jats:italic>in vitro<\/jats:italic> than the irradiation administered alone. Thus, we have demonstrated that the studied copper compounds have a good potential for radioenhancement.<\/jats:p>","DOI":"10.1371\/journal.pone.0253553","type":"journal-article","created":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T17:32:19Z","timestamp":1624037539000},"page":"e0253553","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["The radioenhancement potential of Schiff base derived copper (II) compounds against lung carcinoma in 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