{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:47:43Z","timestamp":1786996063886,"version":"build-2736575974"},"reference-count":66,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T00:00:00Z","timestamp":1624579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"EMRO\/TDR","award":["SGS18\/37"],"award-info":[{"award-number":["SGS18\/37"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\"><jats:title>Background<\/jats:title><jats:p>The emergence of dengue in malaria-endemic countries with limited diagnostic resources, such as Yemen, can be problematic because presumptive treatment of febrile cases as being malaria is a common practice. Co-infections with dengue and malaria are often overlooked and misdiagnosed as being a mono-infection because of clinical similarities. In Hodeidah city, Yemen, the capacity to conduct the diagnosis can be aggravated by the war context. To assess the magnitude of the problem, we determined the proportions of malaria, dengue and co-infection in relation to clinical characteristics among febrile outpatients.<\/jats:p><\/jats:sec><jats:sec id=\"sec002\"><jats:title>Methods<\/jats:title><jats:p>This cross-sectional study included 355 febrile outpatients from Hodeidah city during the malaria transmission season (September 2018 \u2013February 2019). Sociodemographic and clinical characteristics were collected using a pre-designed, structured questionnaire. Malaria was confirmed using microscopy and rapid diagnostic tests (RDTs), while dengue was confirmed using RDTs.<\/jats:p><\/jats:sec><jats:sec id=\"sec003\"><jats:title>Results<\/jats:title><jats:p>Mono-infection proportions of 32.4% for falciparum malaria and 35.2% for dengue were found, where about two-thirds of dengue patients had a recent probable infection. However, co-infection with falciparum malaria and dengue was detected among 4.8% of cases. There was no statistically significant difference between having co-infection and mono-infection with malaria or dengue in relation to the sociodemographic characteristics. On the other hand, the odds of co-infection were significantly lower than the odds of malaria among patients presenting with sweating (OR = 0.1, 95% CI: 0.05\u20130.45;<jats:italic>p<\/jats:italic>&lt;0.001), while the odds of co-infection were 3.5 times significantly higher than the odds of dengue among patients presenting with vomiting (OR = 3.5, 95% CI: 1.20\u201310.04;<jats:italic>p<\/jats:italic>&lt;0.021). However, there were no statistically significant differences between having co-infection and mono-infection (malaria or dengue) in relation to other clinical characteristics.<\/jats:p><\/jats:sec><jats:sec id=\"sec004\"><jats:title>Conclusions<\/jats:title><jats:p>Mono-infection with malaria or dengue can be detected among about one-third of febrile outpatients in Hodeidah, while almost 5.0% of cases can be co-infected. Sociodemographic and clinical characteristics cannot easily distinguish malaria patients from dengue-infected or co-infected ones, reinforcing the necessity of laboratory confirmation and avoidance of treating febrile patients as being presumed malaria cases.<\/jats:p><\/jats:sec>","DOI":"10.1371\/journal.pone.0253556","type":"journal-article","created":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T17:32:10Z","timestamp":1624642330000},"page":"e0253556","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Malaria and dengue in Hodeidah city, Yemen: High proportion of febrile outpatients with dengue or malaria, but low proportion co-infected"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7181-1108","authenticated-orcid":true,"given":"Rashad","family":"Abdul-Ghani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed A. 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Dengue and severe dengue: key facts [cited 2019 11 Nov]. Available from: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/dengue-and-severe-dengue."},{"issue":"1","key":"pone.0253556.ref005","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1186\/s12889-018-5626-z","article-title":"Global prevalence and distribution of coinfection of malaria, dengue and chikungunya: a systematic review.","volume":"18","author":"N Salam","year":"2018","journal-title":"BMC Public Health"},{"issue":"4","key":"pone.0253556.ref006","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/S2221-1691(11)60053-1","article-title":"Concurrent malaria and dengue infection: a brief summary and comment","volume":"1","author":"V. Wiwanitkit","year":"2011","journal-title":"Asian Pac J Trop Biomed"},{"key":"pone.0253556.ref007","first-page":"562175","article-title":"A case of mixed infections in a patient presenting with acute febrile illness in the tropics.","volume":"2013","author":"LS Yong","year":"2013","journal-title":"Case Rep Infect Dis"},{"issue":"6365","key":"pone.0253556.ref008","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1126\/science.aan6836","article-title":"Antibody-dependent enhancement of severe dengue disease in humans","volume":"358","author":"LC Katzelnick","year":"2017","journal-title":"Science"},{"issue":"7","key":"pone.0253556.ref009","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.3201\/eid1107.041352","article-title":"Concurrent dengue and malaria","volume":"11","author":"RN Charrel","year":"2005","journal-title":"Emerg Infect Dis"},{"issue":"1","key":"pone.0253556.ref010","doi-asserted-by":"crossref","first-page":"182","DOI":"10.4269\/ajtmh.2006.75.182","article-title":"A case of fatal Plasmodium falciparum malaria complicated by acute dengue fever in East Timor","volume":"75","author":"DI Ward","year":"2006","journal-title":"Am J Trop Med Hyg"},{"issue":"4","key":"pone.0253556.ref011","doi-asserted-by":"crossref","first-page":"668","DOI":"10.3201\/eid1504.080891","article-title":"Concurrent dengue and malaria in Cayenne Hospital, French Guiana","volume":"15","author":"B Carme","year":"2009","journal-title":"Emerg Infect Dis"},{"issue":"4","key":"pone.0253556.ref012","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S1995-7645(12)60046-7","article-title":"Concurrent dengue and malaria in an area in Kolkata.","volume":"5","author":"AK Hati","year":"2012","journal-title":"Asian Pac J Trop Med"},{"key":"pone.0253556.ref013","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ijid.2013.09.007","article-title":"Concurrent dengue and malaria infection in Lahore, Pakistan during the 2012 dengue outbreak","volume":"18","author":"MZ Assir","year":"2014","journal-title":"Int J Infect Dis"},{"issue":"7","key":"pone.0253556.ref014","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.apjtb.2016.05.008","article-title":"A review of concurrent infections of malaria and dengue in Asia.","volume":"6","author":"AAP Selvaretnam","year":"2016","journal-title":"Asian Pac J Trop Biomed"},{"issue":"4","key":"pone.0253556.ref015","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.4269\/ajtmh.16-0798","article-title":"Surveillance of vector-borne infections (chikungunya, dengue, and malaria) in Bo, Sierra Leone, 2012\u20132013.","volume":"97","author":"DF Dariano","year":"2017","journal-title":"Am J Trop Med Hyg"},{"issue":"1","key":"pone.0253556.ref016","first-page":"25","article-title":"Clinical features, diagnostic techniques and management of dual dengue and malaria infection.","volume":"19","author":"A Abbasi","year":"2009","journal-title":"J Coll Physicians Surg Pak"},{"issue":"6","key":"pone.0253556.ref017","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.4269\/ajtmh.2012.11-0723","article-title":"Dengue outbreak in Hadramout, Yemen, 2010: an epidemiological perspective","volume":"86","author":"AS Bin Ghouth","year":"2012","journal-title":"Am J Trop Med Hyg"},{"key":"pone.0253556.ref018","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/1471-2334-13-136","article-title":"Outbreak of viral hemorrhagic fever caused by dengue virus type 3 in Al-Mukalla, Yemen.","volume":"13","author":"TA Madani","year":"2013","journal-title":"BMC Infect Dis"},{"issue":"8","key":"pone.0253556.ref019","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.3201\/eid2008.131615","article-title":"Co-circulation of dengue and chikungunya viruses, Al Hudaydah, Yemen, 2012","volume":"20","author":"G Rezza","year":"2014","journal-title":"Emerg Infect Dis"},{"key":"pone.0253556.ref020","volume-title":"WHO health emergencies: WHO scales up response to control dengue fever in Yemen","author":"WHO Regional Office for the Eastern Mediterranean","year":"2016"},{"key":"pone.0253556.ref021","unstructured":"World Health Organization. Yemen Health Cluster. health cluster bulletin November-December [cited 2019 12 Feb]. Available from: https:\/\/www.who.int\/health-cluster\/countries\/yemen\/Yemen-Health-Cluster-Bulletin-November-December-2018.pdf."},{"key":"pone.0253556.ref022","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/1475-2875-11-142","article-title":"Is dengue and malaria co-infection more severe than single infections? A retrospective matched-pair study in French Guiana.","volume":"11","author":"L Epelboin","year":"2012","journal-title":"Malar J"},{"issue":"4","key":"pone.0253556.ref023","doi-asserted-by":"crossref","first-page":"262","DOI":"10.4103\/0972-9062.213508","article-title":"Manifestation and outcome of concurrent malaria and dengue infection.","volume":"49","author":"MK Mohapatra","year":"2012","journal-title":"J Vector Borne Dis"},{"issue":"5","key":"pone.0253556.ref024","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/S2221-1691(13)60087-8","article-title":"A case of cerebral malaria and dengue concurrent infection.","volume":"3","author":"A Alam","year":"2013","journal-title":"Asian Pac J Trop Biomed"},{"issue":"1","key":"pone.0253556.ref025","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12936-016-1666-y","article-title":"The dangers of accepting a single diagnosis: case report of concurrent Plasmodium knowlesi malaria and dengue infection.","volume":"16","author":"SE Chong","year":"2017","journal-title":"Malar J"},{"key":"pone.0253556.ref026","volume-title":"Drug resistance in malaria","author":"PB Bloland","year":"2001"},{"issue":"7624","key":"pone.0253556.ref027","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1136\/bmj.39335.541782.AD","article-title":"Strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies.","volume":"335","author":"E von Elm","year":"2007","journal-title":"BMJ"},{"key":"pone.0253556.ref028","unstructured":"Central Statistical Organization. Statistical Year Book for 2017. Available from: http:\/\/www.cso-yemen.com\/content.php?lng=english&id=690."},{"key":"pone.0253556.ref029","unstructured":"World Health Organization. In vitro diagnostics and laboratory technology: WHO list of prequalified in vitro diagnostic products 2018. Available from: https:\/\/www.who.int\/diagnostics_laboratory\/evaluations\/201013_prequalified_product_list.pdf?ua=1."},{"key":"pone.0253556.ref030","unstructured":"Centers for Disease Prevention and Control. Dengue: laboratory guidance and diagnostic testing [cited 2019 12 Nov]. Available from: https:\/\/www.cdc.gov\/dengue\/clinicallab\/laboratory.html."},{"key":"pone.0253556.ref031","volume-title":"District Laboratory Practice in Tropical Countries: Part 1","author":"M. Cheesbrough","year":"2010"},{"key":"pone.0253556.ref032","volume-title":"Basic Malaria Microscopy. Part 1. Learner\u2019s Guide","author":"World Health Organization","year":"2010","edition":"2"},{"issue":"3","key":"pone.0253556.ref033","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jegh.2014.01.004","article-title":"Chikungunya outbreak in Al-Hudaydah, Yemen, 2011: epidemiological characterization and key lessons learned for early detection and control.","volume":"4","author":"MR Malik","year":"2014","journal-title":"J Epidemiol Glob Health"},{"key":"pone.0253556.ref034","unstructured":"International Organization for Migration. IOM Yemen: weekly situation report 20\u201326 May 2018. Available from: https:\/\/displacement.iom.int\/system\/tdf\/reports\/IOM%20Yemen%20-%20Sitrep%20-%2020-26%20May%202018.pdf?file=1&type=node&id=3712."},{"issue":"1","key":"pone.0253556.ref035","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1186\/s12889-019-7488-4","article-title":"Prevalence and laboratory analysis of malaria and dengue co-infection: a systematic review and meta-analysis.","volume":"19","author":"M Kotepui","year":"2019","journal-title":"BMC Public Health"},{"issue":"3","key":"pone.0253556.ref036","first-page":"1","article-title":"Epidemiological characteristic of malaria coinfected with dengue fever in Hodeidah, Yemen.","volume":"40","author":"A Al-Areeqi","year":"2020","journal-title":"Int J Trop Med Health."},{"issue":"3","key":"pone.0253556.ref037","doi-asserted-by":"crossref","first-page":"462","DOI":"10.3201\/eid2403.171723","article-title":"Major threat to malaria control programs by Plasmodium falciparum lacking histidine-rich protein 2, Eritrea","volume":"24","author":"A Berhane","year":"2018","journal-title":"Emerg Infect Dis"},{"issue":"4","key":"pone.0253556.ref038","doi-asserted-by":"crossref","first-page":"e001582","DOI":"10.1136\/bmjgh-2019-001582","article-title":"False-negative malaria rapid diagnostic test results and their impact on community-based malaria surveys in sub-Saharan Africa","volume":"4","author":"OJ Watson","year":"2019","journal-title":"BMJ Glob Health"},{"issue":"1","key":"pone.0253556.ref039","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13104-020-4900-1","article-title":"Renal detection of Plasmodium falciparum, Plasmodium vivax and Plasmodium knowlesi in malaria associated acute kidney injury: a retrospective case-control study.","volume":"13","author":"C Kaur","year":"2020","journal-title":"BMC Res Notes."},{"issue":"8","key":"pone.0253556.ref040","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.3201\/eid2608.191214","article-title":"Association of dengue virus and Leptospira co-infections with malaria severity","volume":"26","author":"R Mandage","journal-title":"Emerg Infect Dis"},{"issue":"1","key":"pone.0253556.ref041","doi-asserted-by":"crossref","first-page":"ofw273","DOI":"10.1093\/ofid\/ofw273","article-title":"Clinical utility of the nonstructural 1 antigen rapid diagnostic test in the management of dengue in returning travelers with fever.","volume":"4","author":"R Huits","year":"2017","journal-title":"Open Forum Infect Dis."},{"issue":"8","key":"pone.0253556.ref042","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1128\/JCM.00521-16","article-title":"Use of a rapid test for diagnosis of dengue during suspected dengue outbreaks in resource-limited regions","volume":"54","author":"EA Hunsperger","year":"2016","journal-title":"J Clin Microbiol"},{"issue":"1","key":"pone.0253556.ref043","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3855\/jidc.2411","article-title":"Evidence of arbovirus co-infection in suspected febrile malaria and typhoid patients in Nigeria.","volume":"7","author":"M Baba","year":"2013","journal-title":"J Infect Dev Ctries"},{"issue":"5","key":"pone.0253556.ref044","first-page":"340","article-title":"Dengue fever in malaria endemic areas.","volume":"16","author":"N Ali","year":"2006","journal-title":"J Coll Physicians Surg Pak"},{"key":"pone.0253556.ref045","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.virusres.2014.07.023","article-title":"High dengue NS1 antigenemia in febrile patients in Ibadan, Nigeria.","volume":"191","author":"OG Oyero","year":"2014","journal-title":"Virus Res"},{"issue":"11","key":"pone.0253556.ref046","doi-asserted-by":"crossref","first-page":"e3335","DOI":"10.1371\/journal.pntd.0003335","article-title":"Dengue and chikungunya fever among viral diseases in outpatient febrile children in Kilosa district hospital, Tanzania.","volume":"8","author":"B Chipwaza","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"issue":"10","key":"pone.0253556.ref047","doi-asserted-by":"crossref","first-page":"e3239","DOI":"10.1371\/journal.pntd.0003239","article-title":"P. vivax malaria and dengue fever co-infection: a cross-sectional study in the Brazilian Amazon.","volume":"8","author":"BM Magalhaes","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"issue":"6","key":"pone.0253556.ref048","first-page":"MC01","article-title":"A Study of etiological pattern in an epidemic of acute febrile illness during monsoon in a tertiary health care institute of Uttarakhand, India.","volume":"8","author":"R Singh","year":"2014","journal-title":"J Clin Diagn Res."},{"issue":"12","key":"pone.0253556.ref049","first-page":"DC22","article-title":"Aetiologies of acute undifferentiated febrile illness in adult patients\u2014an experience from a tertiary care hospital in northern India.","volume":"9","author":"G Mittal","year":"2015","journal-title":"J Clin Diagn Res."},{"issue":"3","key":"pone.0253556.ref050","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/S1995-7645(14)60316-3","article-title":"Dengue in pregnancy: an under-reported illness, with special reference to other existing co-infections","volume":"8","author":"N Singla","year":"2015","journal-title":"Asian Pac J Trop Med"},{"issue":"3","key":"pone.0253556.ref051","doi-asserted-by":"crossref","first-page":"497","DOI":"10.4269\/ajtmh.14-0678","article-title":"Evidence of recent dengue exposure among malaria parasite-positive children in three urban centers in Ghana","volume":"92","author":"J Stoler","year":"2015","journal-title":"Am J Trop Med Hyg"},{"issue":"4","key":"pone.0253556.ref052","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s10096-016-2590-3","article-title":"A comparative hospital-based observational study of mono- and co-infections of malaria, dengue virus and scrub typhus causing acute undifferentiated fever","volume":"35","author":"S Ahmad","year":"2016","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"1","key":"pone.0253556.ref053","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jiph.2015.06.009","article-title":"A survey of malaria and some arboviral infections among suspected febrile patients visiting a health centre in Simawa, Ogun State, Nigeria.","volume":"9","author":"AF Ayorinde","year":"2016","journal-title":"J Infect Public Health"},{"key":"pone.0253556.ref054","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ijid.2016.02.393","article-title":"Concurrent dengue and malaria coinfection: observations from a central Mumbai hospital","volume":"45","author":"A Barua","year":"2016","journal-title":"Int J Infect Dis"},{"key":"pone.0253556.ref055","article-title":"A study on dual infections in pyrexia cases.","volume":"5","author":"JM Raja","year":"2016","journal-title":"Int J Med Res Health Sci."},{"issue":"4","key":"pone.0253556.ref056","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.jiph.2015.10.019","article-title":"Prevalence of dengue viral and malaria parasitic co-infections in an epidemic district, Angul of Odisha, India: An eco-epidemiological and cross-sectional study for the prospective aspects of public health.","volume":"9","author":"MR Rao","year":"2016","journal-title":"J Infect Public Health"},{"issue":"8","key":"pone.0253556.ref057","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1002\/jmv.24788","article-title":"Dengue virus and malaria concurrent infection among febrile subjects within Ilorin metropolis, Nigeria","volume":"89","author":"OM Kolawole","year":"2017","journal-title":"J Med Virol"},{"issue":"2","key":"pone.0253556.ref058","first-page":"17","article-title":"Male-female differences in the number of reported incident dengue fever cases in six Asian countries.","volume":"2","author":"M Anker","year":"2011","journal-title":"Western Pac Surveill Response J"},{"issue":"2","key":"pone.0253556.ref059","first-page":"17","article-title":"Assessment of gender distribution in dengue surveillance data, the Lao People\u2019s Democratic Republic.","volume":"4","author":"N Prasith","year":"2013","journal-title":"Western Pac Surveill Response J"},{"key":"pone.0253556.ref060","doi-asserted-by":"crossref","first-page":"103","DOI":"10.2147\/IDR.S22613","article-title":"Treatment of dengue fever.","volume":"5","author":"S Rajapakse","year":"2012","journal-title":"Infect Drug Resist"},{"issue":"1","key":"pone.0253556.ref061","first-page":"8","article-title":"Dengue fever outbreak: a clinical management experience.","volume":"18","author":"S Ahmed","year":"2008","journal-title":"J Coll Physicians Surg Pak"},{"issue":"1","key":"pone.0253556.ref062","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1017\/S0950268802007641","article-title":"Non-specific alert system for dengue epidemic outbreaks in areas of endemic malaria. A hospital-based evaluation in Cayenne (French Guiana).","volume":"130","author":"B Carme","year":"2003","journal-title":"Epidemiol Infect"},{"key":"pone.0253556.ref063","first-page":"405981","article-title":"Thrombocytopenia as an indicator of malaria in adult population.","volume":"2012","author":"SJ Khan","year":"2012","journal-title":"Malar Res Treat."},{"key":"pone.0253556.ref064","volume-title":"Guidelines for the treatment of malaria","author":"World Health Organization","year":"2010","edition":"2"},{"key":"pone.0253556.ref065","unstructured":"World Health Organization. Test, treat, track: scaling up diagnostic testing, treatment and surveillance for malaria. Geneva: Global Malaria Programme\/ WHO; 2012. Available from: https:\/\/apps.who.int\/iris\/handle\/10665\/337979."},{"issue":"6","key":"pone.0253556.ref066","doi-asserted-by":"crossref","first-page":"e0127962","DOI":"10.1371\/journal.pone.0127962","article-title":"Etiology of severe febrile illness in low- and middle-income countries: a systematic review.","volume":"10","author":"N Prasad","year":"2015","journal-title":"PLoS One."}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0253556","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T17:56:20Z","timestamp":1725299780000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0253556"}},"subtitle":[],"editor":[{"given":"Luzia Helena","family":"Carvalho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,6,25]]},"references-count":66,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,6,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0253556","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,25]]}}}