{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T23:43:56Z","timestamp":1762299836840,"version":"3.37.3"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T00:00:00Z","timestamp":1625788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["368462-RGPIN"],"award-info":[{"award-number":["368462-RGPIN"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research Data Centre"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objectives<\/jats:title>\n<jats:p>We investigated the spatial disparities and factors associated with gastric cancer (GC) Incidence in Manitoba.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>We combined information from Manitoba Cancer registry and Census data to obtain an age-sex adjusted relative risk (IRR) of GC incidence. We geocoded the IRR to the 96 regional health authority districts (RHADs) using the postal code conversion file (PCCF). Bayesian spatial and spatio-temporal Poisson regression models were used for the analysis.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Adjusting for the effect of socio-economic score index (SESI), Indigenous, and immigrant population, 25 districts with high overall GC risk were identified. One unit increase in SESI was associated with reduced risk of cardia GC (CGC) by 14% (IRR = 0.859; 95% CI: 0.780\u20130.947) and the risk of non-cardia GC (NCGC) by approximately 10% (IRR = 0.898; 95% CI: 0.812\u20130.995); 1% increase in regional Indigenous population proportion reduced the risk of CGC by 1.4% (IRR = 0.986; 95% CI: 0.978\u20130.994). In the analysis stratified by sex, one unit increase in SESI reduced the risk of CGC among women by 26.2% (IRR = 0.738; 95% CI: 0.618\u20130.879), and a 1% increase in Indigenous population proportion reduced the risk of CGC among women by 1.9% (IRR = 0.981; 95% CI: 0.966\u20130.996).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Our results support a significant association between SESI and NCGC. We report regional variation of GC IRR and a varying temporal pattern across the RHADs. These results could be used to prioritize interventions for regions with high and progressive risk of GC.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0253650","type":"journal-article","created":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T18:31:20Z","timestamp":1625855480000},"page":"e0253650","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Geographical variation and factors associated with gastric cancer in Manitoba"],"prefix":"10.1371","volume":"16","author":[{"given":"Oluwagbenga","family":"Fakanye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harminder","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Desautels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7448-7729","authenticated-orcid":true,"given":"Mahmoud","family":"Torabi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2021,7,9]]},"reference":[{"journal-title":"CA Cancer J Clin","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries [published online ahead of print 2018]","author":"F Bray","key":"pone.0253650.ref001"},{"volume-title":"Canadian Cancer Statistics 2018","year":"2018","author":"Canadian Cancer Statistics Advisory Committee","key":"pone.0253650.ref002"},{"volume-title":"Cancer Facts and Figures 2019","year":"2019","author":"American Cancer Society","key":"pone.0253650.ref003"},{"issue":"4","key":"pone.0253650.ref004","doi-asserted-by":"crossref","first-page":"250","DOI":"10.3747\/co.23.3123","article-title":"Regional variation in the management of metastatic gastric cancer in Ontario","volume":"23","author":"A. L. Mahar","year":"2016","journal-title":"Current Oncology"},{"issue":"10","key":"pone.0253650.ref005","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1007\/s00477-018-1531-3","article-title":"Bayesian spatio-temporal analysis of stomach cancer incidence in Iran, 2003\u20132010","volume":"32","author":"Z. Sharafi","year":"2018","journal-title":"Stochastic environmental research and risk assessment"},{"issue":"4","key":"pone.0253650.ref006","doi-asserted-by":"crossref","first-page":"534","DOI":"10.3390\/cancers11040534","article-title":"Gastric Cancer in Northern Canadian Populations: A Focus on Cardia and Non-Cardia Subsites","volume":"11","author":"CANHelp Working Group","year":"2019","journal-title":"Cancers"},{"key":"pone.0253650.ref007","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1136\/jech.52.3.166","article-title":"Socioeconomic status and stomach cancer incidence in men: results from The Netherlands Cohort Study","volume":"52","author":"AJ van Loon","year":"1998","journal-title":"J Epidemiol Community Health"},{"volume-title":"Bumsted, Peter McLintock and Others: Manitoba","year":"2019","author":"M John","key":"pone.0253650.ref008"},{"volume-title":"Burland, E, Prior, H., Burchill, C., Chateau, D., Walld, R., Sex Differences in Health Status, Health Care Use, and Quality of Care: A Population-Based Analysis for Manitoba\u2019s Regional Health Authorities","year":"2005","author":"The Need to Know Team","key":"pone.0253650.ref009"},{"issue":"2","key":"pone.0253650.ref010","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1538-4632.2012.00839.x","article-title":"\u201cHierarchical Bayesian Spatiotemporal Analysis of Childhood Cancer Trends.\u201d","volume":"44","author":"M. Torabi","year":"2012","journal-title":"Geographical Analysis"},{"volume-title":"ArcGIS for Desktop, version 10.2.2","year":"2014","author":"ESRI","key":"pone.0253650.ref011"},{"key":"pone.0253650.ref012","volume-title":"Parkin D: International classification of diseases for oncology","author":"P Fritz","year":"2000","edition":"3"},{"journal-title":"Canadian Cancer registry","year":"2019","author":"Statistics Canada","key":"pone.0253650.ref013"},{"issue":"1","key":"pone.0253650.ref014","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1093\/ije\/dyl275","article-title":"Socioeconomic position and the risk of gastric and oesophageal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST)","volume":"36","author":"G. Nagel","year":"2007","journal-title":"International journal of epidemiology"},{"issue":"2","key":"pone.0253650.ref015","doi-asserted-by":"crossref","first-page":"e89655","DOI":"10.1371\/journal.pone.0089655","article-title":"The effect of individual and neighborhood socioeconomic status on gastric cancer survival","volume":"9","author":"C. C. Wu","year":"2014","journal-title":"PloS one"},{"issue":"4","key":"pone.0253650.ref016","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.cgh.2016.11.033","article-title":"Racial and ethnic minorities at increased risk for gastric cancer in a regional US population study","volume":"15","author":"E. Dong","year":"2017","journal-title":"Clinical Gastroenterology and Hepatology"},{"issue":"2","key":"pone.0253650.ref017","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.compenvurbsys.2007.08.009","article-title":"The geography of mortality in the Atlanta metropolitan area","volume":"32","author":"J Holt","year":"2008","journal-title":"Computers, Environment and Urban Systems"},{"key":"pone.0253650.ref018","unstructured":"Krishnan V (2010). Constructing an area-based socioeconomic status index: A principal component analysis approach. Early Childhood Council Annual Conference 2010, 2010, May 7, Christchurch, New Zealand."},{"volume-title":"\"A review of methods for deriving an index for socioeconomic status in British Columbia","year":"2013","author":"Kyle Vincent","key":"pone.0253650.ref019"},{"issue":"3","key":"pone.0253650.ref020","article-title":"Construction of a Socio-Economic Status (SES) Index in Peninsular Malaysia Using the Factor Analysis Approach","volume":"26","author":"N. Abdul Rahman","year":"2018","journal-title":"Pertanika Journal of Social Sciences & Humanities"},{"issue":"1","key":"pone.0253650.ref021","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1023\/A:1008849014992","article-title":"The incidence of gastric carcinoma in Asian migrants to the United States and their descendants","volume":"10","author":"A. Kamineni","year":"1999","journal-title":"Cancer causes & control"},{"issue":"1","key":"pone.0253650.ref022","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1177\/107327480701400111","article-title":"Cancer incidence among Korean-American immigrants in the United States and native Koreans in South Korea","volume":"14","author":"J. Lee","year":"2007","journal-title":"Cancer Control"},{"issue":"3","key":"pone.0253650.ref023","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s10120-011-0033-5","article-title":"Does immigration play a role in the risk of gastric cancer by site and by histological type? A study of first-generation immigrants in Sweden","volume":"14","author":"S. M. Mousavi","year":"2011","journal-title":"Gastric cancer"},{"issue":"15","key":"pone.0253650.ref024","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1016\/S1470-2045(15)00232-6","article-title":"Cancer incidence in indigenous people in Australia, New Zealand, Canada, and the USA: a comparative population-based study","volume":"16","author":"S. P. Moore","year":"2015","journal-title":"The Lancet Oncology"},{"issue":"1","key":"pone.0253650.ref025","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1136\/gutjnl-2013-305033","article-title":"The burden of stomach cancer in indigenous populations: a systematic review and global assessment","volume":"63","author":"M. Arnold","year":"2014","journal-title":"Gut"},{"issue":"1","key":"pone.0253650.ref026","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00116466","article-title":"Bayesian image restoration, with two applications in spatial statistics","volume":"43","author":"J. Besag","year":"1991","journal-title":"Annals of the institute of statistical mathematics"},{"issue":"17\u201018","key":"pone.0253650.ref027","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1002\/1097-0258(20000915\/30)19:17\/18<2555::AID-SIM587>3.0.CO;2-#","article-title":"Bayesian modelling of inseparable space\u2010time variation in disease risk","volume":"19","author":"L. Knorr\u2010Held","year":"2000","journal-title":"Statistics in medicine"},{"issue":"4","key":"pone.0253650.ref028","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1155\/2014\/707420","article-title":"Geographical variation and factors associated with colorectal cancer mortality in a universal health care system","volume":"28","author":"M Torabi","year":"2014","journal-title":"Can J Gastroenterol Hepatol"},{"issue":"4","key":"pone.0253650.ref029","first-page":"581","article-title":"Geographical variation and factors associated with inflammatory bowel disease in a central Canadian province","volume":"26","author":"M. Torabi","year":"2020","journal-title":"Inflammatory Bowel Diseases"},{"key":"pone.0253650.ref030","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1186\/1471-2458-14-285","article-title":"Bowel disorders and its spatial trend in Manitoba, Canada","volume":"14","author":"M Torabi","year":"2014","journal-title":"BMC Public Health"},{"key":"pone.0253650.ref031","doi-asserted-by":"crossref","DOI":"10.1002\/0471662682","volume-title":"Applied spatial statistics for public health data","author":"L.A. Waller","year":"2004"},{"key":"pone.0253650.ref032","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1590\/S1020-49892004001100006","article-title":"Cancer among indigenous people in the Amazon Basin of Ecuador, 1985\u20132000","volume":"16","author":"M. S. 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