{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:29:55Z","timestamp":1790738995549,"version":"4.1.0"},"reference-count":53,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T00:00:00Z","timestamp":1628467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009270","name":"Invention for Innovation","doi-asserted-by":"publisher","award":["II-LA-1117-20001"],"award-info":[{"award-number":["II-LA-1117-20001"]}],"id":[{"id":"10.13039\/501100009270","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009270","name":"Invention for Innovation","doi-asserted-by":"publisher","award":["II-LA-1117-20001"],"award-info":[{"award-number":["II-LA-1117-20001"]}],"id":[{"id":"10.13039\/501100009270","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009270","name":"Invention for Innovation","doi-asserted-by":"publisher","award":["II-LA-1117-20001"],"award-info":[{"award-number":["II-LA-1117-20001"]}],"id":[{"id":"10.13039\/501100009270","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"national institute for health research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000272","name":"national institute for health research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000272","name":"national institute for health research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"name":"medical research council"},{"name":"developmental pathway funding scheme"},{"DOI":"10.13039\/100002089","name":"fight for sight","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011327","name":"sandwell and west birmingham hospitals nhs trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011327","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"british heart foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"crossref"}]},{"name":"national institute for health research medtech and invitro diagnostic co-operative \u2013 trauma management"},{"name":"eye hope foundation"},{"name":"association du syndrome de wolfram"},{"name":"snow foundation"},{"DOI":"10.13039\/100014475","name":"pfizer health research foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014475","id-type":"DOI","asserted-by":"publisher"}]},{"name":"national institute for health research clinical research network"},{"name":"birmingham biomedical research centre and national institute for health research surgical reconstruction and microbiology research centre"},{"name":"university hospitals birmingham national health service foundation trust"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Patient-reported outcome measures (PROMs) can provide valuable insights on the impact of a disease or treatment on a patient\u2019s health-related quality of life. In ophthalmology, particularly in dry eye disease (DED) and ocular surface disease (OSD), it is unclear whether the available PROMs were developed using comprehensive guidelines. To address this, we evaluated the methodological quality of studies assessing the psychometric properties of PROMs in DED and OSD [PROSPERO registration number CRD42019142328].<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Four databases were searched; reference list and citation searching of included studies was also conducted. The COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) checklist was used to appraise the quality of the studies evaluating the psychometric properties of PROMs used in DED and OSD.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>The search strategy (S3 Table) retrieved 5,761 records, 573 duplicates were removed, 5,188 abstracts were screened and 127 full-text articles were retrieved for further review. Of these, 118 full-text articles did not meet the eligibility criteria and were excluded. Reference list and citation searching, identified an additional 8 articles bringing the total numbers of papers reviewed to 17. In general, psychometric properties such as content validity, measurement error and structural validity were not assessed by the studies included in this review. Studies reviewing The Impact of Dry Eye on Everyday Life (IDEEL) presented with the highest quality scores together with the Ocular Surface Disease Index (OSDI) questionnaire.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The quality of studies evaluating PROMs in DED and OSD was considered using the COSMIN standards. The majority of the studies evaluating PROMs included in this review did not meet the recommended COSMIN criteria and the quality of the PROMs evaluated is not assured. Further evaluation of their psychometric properties is required if these are going to be used in clinical practice or research.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0253857","type":"journal-article","created":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T18:22:46Z","timestamp":1628533366000},"page":"e0253857","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["A systematic review assessing the quality of patient reported outcomes measures in dry eye diseases"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9708-2588","authenticated-orcid":true,"given":"Alberto","family":"Recchioni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9122-8251","authenticated-orcid":true,"given":"Olalekan Lee","family":"Aiyegbusi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Cruz-Rivera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4627-3496","authenticated-orcid":true,"given":"Saaeha","family":"Rauz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2827-7741","authenticated-orcid":true,"given":"Anita","family":"Slade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,8,9]]},"reference":[{"issue":"3","key":"pone.0253857.ref001","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jtos.2017.05.008","article-title":"TFOS DEWS II Definition and Classification Report","volume":"15","author":"J Craig","year":"2017","journal-title":"Ocul Surf."},{"key":"pone.0253857.ref002","volume-title":"Ocular Surface Disease: Cornea, Conjunctiva and Tear Film E-Book: Expert Consult\u2014Online and Print","author":"EJ Holland","year":"2013"},{"issue":"1","key":"pone.0253857.ref003","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/s12955-018-0999-3","article-title":"Quality of life measures and health utility values among dry eye subgroups","volume":"16","author":"C Shigeyasu","year":"2018","journal-title":"Health Qual Life Outcomes"},{"key":"pone.0253857.ref004","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.jtos.2017.05.003","article-title":"TFOS DEWS II Epidemiology Report","volume":"15","author":"F Stapleton","year":"2017","journal-title":"Ocul Surf."},{"key":"pone.0253857.ref005","article-title":"The Royal College of Ophthalmologists guidelines on serum eye drops for the treatment of severe ocular surface disease: full report","author":"S Rauz","year":"2017","journal-title":"Eye (Lond)"},{"issue":"3","key":"pone.0253857.ref006","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.jtos.2017.05.006","article-title":"TFOS DEWS II Management and Therapy Report","volume":"15","author":"L Jones","year":"2017","journal-title":"Ocul Surf."},{"issue":"1","key":"pone.0253857.ref007","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s10561-009-9128-1","article-title":"Serum eye drops, amniotic membrane and limbal epithelial stem cells\u2014tools in the treatment of ocular surface disease","volume":"11","author":"S Rauz","year":"2010","journal-title":"Cell Tissue Bank"},{"issue":"6","key":"pone.0253857.ref008","doi-asserted-by":"crossref","first-page":"e0199131","DOI":"10.1371\/journal.pone.0199131","article-title":"Association between dry eye symptoms and suicidal ideation in a Korean adult population","volume":"13","author":"SB Um","year":"2018","journal-title":"PLoS One"},{"issue":"3","key":"pone.0253857.ref009","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S1542-0124(12)70043-5","article-title":"Utility assessment to measure the impact of dry eye disease","volume":"4","author":"P Buchholz","year":"2006","journal-title":"Ocul Surf"},{"key":"pone.0253857.ref010","doi-asserted-by":"crossref","first-page":"353","DOI":"10.2147\/PROM.S156279","article-title":"The importance of patient-reported outcomes in clinical trials and strategies for future optimization","volume":"9","author":"R Mercieca-Bebber","year":"2018","journal-title":"Patient Relat Outcome Meas"},{"issue":"8 Suppl 3","key":"pone.0253857.ref011","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.1097\/MLR.0b013e31829b1d84","article-title":"Patient-reported outcomes (PROs): putting the patient perspective in patient-centered outcomes research","volume":"51","author":"CF Snyder","year":"2013","journal-title":"Med Care."},{"issue":"1","key":"pone.0253857.ref012","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s40900-018-0092-4","article-title":"Patient led PROMs must take centre stage in cancer research","volume":"4","author":"R Wilson","year":"2018","journal-title":"Research Involvement and Engagement"},{"issue":"4","key":"pone.0253857.ref013","doi-asserted-by":"crossref","first-page":"48","DOI":"10.12927\/hcpap.2012.22705","article-title":"Getting ready for patient-reported outcomes measures (PROMs) in clinical practice","volume":"11","author":"AW Wu","year":"2011","journal-title":"Healthc Pap"},{"issue":"8","key":"pone.0253857.ref014","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.jval.2011.06.014","article-title":"Content validity\u2014establishing and reporting the evidence in newly developed patient-reported outcomes (PRO) instruments for medical product evaluation: ISPOR PRO good research practices task force report: part 1\u2014eliciting concepts for a new PRO instrument","volume":"14","author":"DL Patrick","year":"2011","journal-title":"Value Health"},{"key":"pone.0253857.ref015","doi-asserted-by":"crossref","first-page":"9","DOI":"10.2147\/PROM.S162802","article-title":"The use of patient-reported outcome research in modern ophthalmology: impact on clinical trials and routine clinical practice","volume":"10","author":"T Braithwaite","year":"2019","journal-title":"Patient Relat Outcome Meas"},{"key":"pone.0253857.ref016","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/1477-7525-4-79","article-title":"Guidance for industry: patient-reported outcome measures: use in medical product development to support labeling claims: draft guidance","volume":"4","author":"FDA","year":"2006","journal-title":"Health Qual Life Outcomes"},{"key":"pone.0253857.ref017","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/ICO.0000000000000038","article-title":"A review of quality of life measures in dry eye questionnaires","volume":"33","author":"JR Grubbs","year":"2014","journal-title":"Cornea"},{"issue":"1","key":"pone.0253857.ref018","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1471-2288-6-2","article-title":"Protocol of the COSMIN study: COnsensus-based Standards for the selection of health Measurement INstruments","volume":"6","author":"LB Mokkink","year":"2006","journal-title":"BMC Medical Research Methodology"},{"issue":"5","key":"pone.0253857.ref019","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1007\/s11136-018-1798-3","article-title":"COSMIN guideline for systematic reviews of patient-reported outcome measures","volume":"27","author":"CAC Prinsen","year":"2018","journal-title":"Qual Life Res"},{"key":"pone.0253857.ref020","unstructured":"Higgins J, Thomas J, Chandler J, Cumpston MT, Page MJ, Welch VA. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. 5.1.0 ed. Cochrane, editor: Cochrane 2011 2011."},{"key":"pone.0253857.ref021","doi-asserted-by":"crossref","first-page":"b2700","DOI":"10.1136\/bmj.b2700","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration","volume":"339","author":"A Liberati","year":"2009","journal-title":"BMJ"},{"issue":"8","key":"pone.0253857.ref022","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1007\/s11136-009-9528-5","article-title":"Development of a methodological PubMed search filter for finding studies on measurement properties of measurement instruments","volume":"18","author":"C Terwee","year":"2009","journal-title":"Qual Life Res"},{"issue":"5","key":"pone.0253857.ref023","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1007\/s11136-018-1798-3","article-title":"COSMIN guideline for systematic reviews of patient-reported outcome measures","volume":"27","author":"C Prinsen","year":"2018","journal-title":"Qual Life Res"},{"issue":"4","key":"pone.0253857.ref024","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1007\/s11136-011-9960-1","article-title":"Rating the methodological quality in systematic reviews of studies on measurement properties: a scoring system for the COSMIN checklist","volume":"21","author":"C Terwee","year":"2012","journal-title":"Qual Life Res"},{"issue":"1","key":"pone.0253857.ref025","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1001\/archophthalmol.2009.356","article-title":"Minimal clinically important difference for the ocular surface disease index","volume":"128","author":"KL Miller","year":"2010","journal-title":"Arch Ophthalmol"},{"key":"pone.0253857.ref026","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1001\/archopht.118.5.615","article-title":"Reliability and validity of the Ocular Surface Disease Index","volume":"118","author":"R Schiffman","year":"2000","journal-title":"Arch Ophthalmol"},{"issue":"12","key":"pone.0253857.ref027","doi-asserted-by":"crossref","first-page":"8630","DOI":"10.1167\/iovs.11-8027","article-title":"Rasch analysis of the Ocular Surface Disease Index (OSDI)","volume":"52","author":"BE Dougherty","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"pone.0253857.ref028","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/1477-7525-9-111","article-title":"Development and validation of the impact of dry eye on everyday life (IDEEL) questionnaire, a patient-reported outcomes (PRO) measure for the assessment of the burden of dry eye on patients","volume":"9","author":"L Abetz","year":"2011","journal-title":"Health Qual Life Outcomes"},{"issue":"8","key":"pone.0253857.ref029","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1097\/OPX.0b013e3181824e0d","article-title":"Clinically important difference in dry eye: change in IDEEL-symptom bother","volume":"85","author":"CJ Fairchild","year":"2008","journal-title":"Optom Vis Sci"},{"issue":"1","key":"pone.0253857.ref030","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/s12955-017-0718-5","article-title":"Development and validation of the Chinese version of dry eye related quality of life scale","volume":"15","author":"B Zheng","year":"2017","journal-title":"Health Qual Life Outcomes"},{"issue":"1","key":"pone.0253857.ref031","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/S1542-0124(12)70053-8","article-title":"Development and validation of a short global dry eye symptom index","volume":"5","author":"D Schaumberg","year":"2007","journal-title":"Ocul Surf"},{"issue":"7","key":"pone.0253857.ref032","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1016\/j.ophtha.2015.02.037","article-title":"Comparison of Two Questionnaires for Dry Eye Symptom Assessment: The Ocular Surface Disease Index and the Symptom Assessment in Dry Eye","volume":"122","author":"F Amparo","year":"2015","journal-title":"Ophthalmology"},{"issue":"11","key":"pone.0253857.ref033","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1097\/ICO.0000000000000243","article-title":"Instrument development of the UNC Dry Eye Management Scale","volume":"33","author":"J Grubbs","year":"2014","journal-title":"Cornea"},{"issue":"9","key":"pone.0253857.ref034","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1097\/ICO.0000000000001287","article-title":"Determination of the Minimal Clinically Important Difference of the University of North Carolina Dry Eye Management Scale","volume":"36","author":"CJ Hwang","year":"2017","journal-title":"Cornea"},{"issue":"1","key":"pone.0253857.ref035","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12955-018-0839-5","article-title":"Development and evaluation of a measure of patient-reported symptoms of Blepharitis","volume":"16","author":"K Hosseini","year":"2018","journal-title":"Health Qual Life Outcomes"},{"issue":"10","key":"pone.0253857.ref036","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1001\/jamaophthalmol.2013.4503","article-title":"Development and validation of the Dry Eye-Related Quality-of-Life Score questionnaire","volume":"131","author":"Y Sakane","year":"2013","journal-title":"JAMA ophthalmology"},{"issue":"1","key":"pone.0253857.ref037","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1097\/ICL.0000000000000294","article-title":"Development of a Meibomian Gland Dysfunction-Specific Symptom Questionnaire","volume":"44","author":"JR Paugh","year":"2018","journal-title":"Eye Contact Lens"},{"issue":"6","key":"pone.0253857.ref038","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1097\/00003226-200208000-00009","article-title":"Performance and repeatability of the NEI-VFQ-25 in patients with dry eye","volume":"21","author":"KK Nichols","year":"2002","journal-title":"Cornea"},{"issue":"10","key":"pone.0253857.ref039","doi-asserted-by":"crossref","first-page":"4451","DOI":"10.1167\/iovs.06-1253","article-title":"Measurement of ocular surface irritation on a linear interval scale with the ocular comfort index","volume":"48","author":"ME Johnson","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"9","key":"pone.0253857.ref040","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1097\/ICO.0b013e318294b0c0","article-title":"Psychometric properties and validation of the Standard Patient Evaluation of Eye Dryness questionnaire","volume":"32","author":"W Ngo","year":"2013","journal-title":"Cornea"},{"issue":"4","key":"pone.0253857.ref041","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1076\/opep.5.4.185.4191","article-title":"Development of a questionnaire for measurement of vision-related quality of life","volume":"5","author":"NA Frost","year":"1998","journal-title":"Ophthalmic Epidemiol"},{"issue":"1","key":"pone.0253857.ref042","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jclinepi.2006.03.012","article-title":"Quality criteria were proposed for measurement properties of health status questionnaires","volume":"60","author":"C Terwee","year":"2007","journal-title":"J Clin Epidemiol"},{"issue":"1","key":"pone.0253857.ref043","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1186\/s13063-016-1555-2","article-title":"How to select outcome measurement instruments for outcomes included in a \u201cCore Outcome Set\u201d\u2013a practical guideline","volume":"17","author":"C Prinsen","year":"2016","journal-title":"Trials"},{"key":"pone.0253857.ref044","doi-asserted-by":"crossref","first-page":"345","DOI":"10.2147\/PROM.S141378","article-title":"The National Institutes of Health Patient-Reported Outcomes Measurement Information System (PROMIS): a view from the UK","volume":"9","author":"J Evans","year":"2018","journal-title":"Patient Relat Outcome Meas"},{"key":"pone.0253857.ref045","author":"D Navarro","year":"2015","journal-title":"Learning Statistics with R: Daniel Joseph Navarro"},{"issue":"7","key":"pone.0253857.ref046","first-page":"950","article-title":"Rasch analysis of a new stroke-specific outcome scale: the Stroke Impact Scale","volume":"84","author":"PW Duncan","year":"2003","journal-title":"Arch Phys Med Rehabil"},{"issue":"6","key":"pone.0253857.ref047","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/eye.2014.41","article-title":"An introduction to patient-reported outcome measures in ophthalmic research","volume":"28","author":"AK Denniston","year":"2014","journal-title":"Eye and vision (London, England)"},{"issue":"1","key":"pone.0253857.ref048","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s40900-018-0109-z","article-title":"Taking patient reported outcomes centre stage in cancer research\u2013why has it taken so long?","volume":"4","author":"P Selby","year":"2018","journal-title":"Research Involvement and Engagement"},{"issue":"8","key":"pone.0253857.ref049","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1002\/art.23108","article-title":"The Rasch measurement model in rheumatology: what is it and why use it? When should it be applied, and what should one look for in a Rasch paper","volume":"57","author":"A Tennant","year":"2007","journal-title":"Arthritis Rheum"},{"issue":"Suppl 2","key":"pone.0253857.ref050","doi-asserted-by":"crossref","first-page":"S125","DOI":"10.1111\/j.1524-4733.2007.00275.x","article-title":"Patient-reported outcomes to support medical product labeling claims: FDA perspective","volume":"10","author":"DL Patrick","year":"2007","journal-title":"Value Health"},{"key":"pone.0253857.ref051","doi-asserted-by":"crossref","first-page":"c2921","DOI":"10.1136\/bmj.c2921","article-title":"FDA guidance on patient reported outcomes","volume":"340","author":"J Speight","year":"2010","journal-title":"BMJ"},{"key":"pone.0253857.ref052","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2046-4053-4-1","article-title":"Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement","volume":"4","author":"D Moher","year":"2015","journal-title":"Syst Rev"},{"issue":"1","key":"pone.0253857.ref053","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/s12955-018-0951-6","article-title":"Patient-reported outcome measures used in patients with primary sclerosing cholangitis: a systematic review","volume":"16","author":"F Isa","year":"2018","journal-title":"Health Qual Life Outcomes"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0253857","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T18:23:50Z","timestamp":1628533430000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0253857"}},"subtitle":[],"editor":[{"given":"Peter M.","family":"ten Klooster","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,8,9]]},"references-count":53,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2021,8,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0253857","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,9]]}}}