{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T01:38:56Z","timestamp":1768873136603,"version":"3.49.0"},"reference-count":25,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T00:00:00Z","timestamp":1624492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Daegu-Gyeongbuk Branch of the Korea Association for the study of the liver"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background and aims<\/jats:title>\n<jats:p>The low-salt diet is considered important for control of ascites in cirrhotic patients. To validate whether the spot urine sodium (Na)\/potassium (K) ratio could replace 24-h urine Na (uNa) excretion in assessing low-salt diet compliance.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>We prospectively studied 175 patients. 24-h urine collection and spot urine collection were performed. Subsequently, 24-h uNa, urine creatinine (uCr), and spot urine Na and K were assessed. A complete urine collection was confirmed based on 24-h uCr excretion levels of 15mg\/kg\/day for men and 10mg\/kg\/day for women. The area under the receiver operating characteristic (AUROC) curve analysis was performed to evaluate the feasibility of spot urine Na\/K ratio in predicting 24-h uNa greater than 78mmol\/day.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Out of 175 patients, 24-h urine samples were completely collected in 57 patients only. Moreover, urine samples were not completely collected in 118 patients because their 24-h uCr excretion level was less than the established criteria. In complete urine collection group, AUROC curve for spot urine Na\/K ratio in predicting 24-h uNa greater than 78mmol\/day was 0.874\u00b10.051 (P&lt;0.001). In the incomplete urine collection group, the AUROC was 0.832\u00b10.039 (P&lt;0.001). In complete urine collection group, the classical cutoff value greater than 1.0 of spot urine Na\/K ratio showed 90.9% sensitivity and 56.0% specificity.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The spot urine Na\/K ratio reflects 24-h uNa, but the AUROC value obtained in this study is lower than that of a previous study. Considered the large number of patients with incomplete urine collection, validating 24-h complete urine collection criteria is necessary.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0253886","type":"journal-article","created":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T17:41:37Z","timestamp":1624556497000},"page":"e0253886","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Diagnostic usefulness of the spot urine sodium\/potassium ratio in cirrhotic patients with ascites"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5312-4053","authenticated-orcid":true,"given":"Jin Wook","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Seok","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woo 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