{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T14:28:51Z","timestamp":1774535331144,"version":"3.50.1"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T00:00:00Z","timestamp":1626134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\"><jats:title>Objectives<\/jats:title><jats:p>Autoimmune bullous diseases vary in their clinico-epidemiological features and burden across populations. Data about these diseases was lacking in Sudan. We aimed to describe the epidemiological profile and to estimate the burden of autoimmune bullous diseases in Sudan.<\/jats:p><\/jats:sec><jats:sec id=\"sec002\"><jats:title>Methods<\/jats:title><jats:p>This was a retrospective cross-sectional study conducted at Khartoum Dermatological and Venereal Diseases Teaching Hospital. We used routinely collected health care data, and included all patients with an autoimmune bullous disease who presented to the hospital between 2001 and 2016.<\/jats:p><\/jats:sec><jats:sec id=\"sec003\"><jats:title>Results<\/jats:title><jats:p>Out of the 4736 patients who were admitted to the hospital during the study period, 923 (19.5%) had an autoimmune bullous disease. The average rate of patients at the hospital was 57.7 per year representing 1.3 per 100,000 population per year. After exclusion of patients where the final diagnosis was missing, 585 were included in the further analysis. Pemphigus vulgaris was the most common disease (50.9%), followed by bullous pemphigoid (28.2%), linear IgA disease\/chronic bullous disease of childhood (8.4%), and pemphigus foliaceous (8.2%). Pemphigoid gestationis and IgA pemphigus constituted 1.4% and 1.2% of the cohort, respectively. Paraneoplastic pemphigus, mucous membrane pemphigoid, lichen planus pemphigoidis, bullous systemic lupus erythematosus, and dermatitis herpetiformis were rare. None of the patients had epidermolysis bullosa acquisita.<\/jats:p><\/jats:sec><jats:sec id=\"sec004\"><jats:title>Conclusions<\/jats:title><jats:p>The clinico-epidemiological characteristics vary among the types of autoimmune bullous diseases. Females were more predominant in most of them. Sudanese patients tended in general to present at a younger age than other populations. The pool of Sudanese patients with autoimmune bullous diseases is large which requires investigation for the local risk factors and presents a field for future trials.<\/jats:p><\/jats:sec>","DOI":"10.1371\/journal.pone.0254634","type":"journal-article","created":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T17:25:31Z","timestamp":1626197131000},"page":"e0254634","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["The epidemiology of autoimmune bullous diseases in Sudan between 2000 and 2016"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3106-996X","authenticated-orcid":true,"given":"Omayma","family":"Siddig","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayson B.","family":"Mustafa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yousif","family":"Kordofani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Gibson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed M.","family":"Suleiman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2021,7,13]]},"reference":[{"key":"pone.0254634.ref001","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1111\/j.1600-0625.2005.00367.x","article-title":"Mechanisms of blister induction by autoantibodies","volume":"14","author":"C Sitaru","year":"2005","journal-title":"Exp Dermatol"},{"key":"pone.0254634.ref002","doi-asserted-by":"crossref","DOI":"10.1002\/9781444317633","volume-title":"Rook\u2019s textbook of dermatology: in four volumes","author":"T Burns","year":"2010","edition":"8"},{"key":"pone.0254634.ref003","first-page":"1861","article-title":"Autoimmune bullous dermatoses: a review","volume":"65","author":"K Bickle","year":"2002","journal-title":"Am Fam Physician"},{"key":"pone.0254634.ref004","volume-title":"Statistical Package for Social Sciences"},{"key":"pone.0254634.ref005","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1365-4632.2011.04946.x","article-title":"Spectrum of autoimmune bullous diseases in Iran: a 10-year review","volume":"51","author":"M Daneshpazhooh","year":"2012","journal-title":"Int J Dermatol"},{"key":"pone.0254634.ref006","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1111\/j.1365-4632.2010.04801.x","article-title":"Spectrum of autoimmune blistering dermatoses in Tunisia: an 11-year study and a review of the literature","volume":"50","author":"I Zaraa","year":"2011","journal-title":"Int J Dermatol"},{"key":"pone.0254634.ref007","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1111\/j.1365-4632.2009.04345.x","article-title":"Pemphigus vulgaris is the most common autoimmune bullous disease","volume":"49","author":"A Baican","year":"2010","journal-title":"Northwestern Romania. 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