{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:10:09Z","timestamp":1790100609421,"version":"4.0.1"},"reference-count":61,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T00:00:00Z","timestamp":1628035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008984","name":"International Anesthesia Research Society","doi-asserted-by":"publisher","award":["Mentored Research Award"],"award-info":[{"award-number":["Mentored Research Award"]}],"id":[{"id":"10.13039\/100008984","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007921","name":"University of Pittsburgh","doi-asserted-by":"crossref","award":["School of Medicine"],"award-info":[{"award-number":["School of Medicine"]}],"id":[{"id":"10.13039\/100007921","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>In clinical practice, the bodily distribution of chronic pain is often used in conjunction with other signs and symptoms to support a diagnosis or treatment plan. For example, the diagnosis of fibromyalgia involves tallying the areas of pain that a patient reports using a drawn body map. It remains unclear whether patterns of pain distribution independently inform aspects of the pain experience and influence patient outcomes. The objective of the current study was to evaluate the clinical relevance of patterns of pain distribution using an algorithmic approach agnostic to diagnosis or patient-reported facets of the pain experience.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods and findings<\/jats:title>\n<jats:p>A large cohort of patients (N = 21,658) completed pain body maps and a multi-dimensional pain assessment. Using hierarchical clustering of patients by body map selection alone, nine distinct subgroups emerged with different patterns of body region selection. Clinician review of cluster body maps recapitulated some clinically-relevant patterns of pain distribution, such as low back pain with radiation below the knee and widespread pain, as well as some unique patterns. Demographic and medical characteristics, pain intensity, pain impact, and neuropathic pain quality all varied significantly across cluster subgroups. Multivariate modeling demonstrated that cluster membership independently predicted pain intensity and neuropathic pain quality. In a subset of patients who completed 3-month follow-up questionnaires (N = 7,138), cluster membership independently predicted the likelihood of improvement in pain, physical function, and a positive overall impression of change related to multidisciplinary pain care.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>This study reports a novel method of grouping patients by pain distribution using an algorithmic approach. Pain distribution subgroup was significantly associated with differences in pain intensity, impact, and clinically relevant outcomes. In the future, algorithmic clustering by pain distribution may be an important facet in chronic pain biosignatures developed for the personalization of pain management.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0254862","type":"journal-article","created":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T17:22:51Z","timestamp":1628097771000},"page":"e0254862","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":46,"title":["Hierarchical clustering by patient-reported pain distribution alone identifies distinct chronic pain subgroups differing by pain intensity, quality, and clinical outcomes"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0171-3411","authenticated-orcid":true,"given":"Benedict J.","family":"Alter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan P.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea G.","family":"Gillman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Hyeon","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6394-6077","authenticated-orcid":true,"given":"Ajay D.","family":"Wasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,8,4]]},"reference":[{"issue":"7","key":"pone.0254862.ref001","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1097\/j.pain.0000000000000507","article-title":"Do we need a third mechanistic descriptor for chronic pain states?","volume":"157","author":"E Kosek","year":"2016","journal-title":"Pain"},{"key":"pone.0254862.ref002","article-title":"Classification algorithm for the International Classification of Diseases-11 chronic pain classification: development and results from a preliminary pilot evaluation","author":"B Korwisi","year":"2021","journal-title":"Pain"},{"issue":"9 Suppl","key":"pone.0254862.ref003","doi-asserted-by":"crossref","first-page":"T10","DOI":"10.1016\/j.jpain.2015.08.010","article-title":"Assessment of Chronic Pain: Domains, Methods, and Mechanisms.","volume":"17","author":"RB Fillingim","year":"2016","journal-title":"J Pain."},{"issue":"5","key":"pone.0254862.ref004","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.jpain.2017.02.421","article-title":"The ACTTION-APS-AAPM Pain Taxonomy (AAAPT) Multidimensional Approach to Classifying Acute Pain Conditions.","volume":"18","author":"ML Kent","year":"2017","journal-title":"J Pain."},{"issue":"1","key":"pone.0254862.ref005","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0304-3959(86)90026-6","article-title":"A rating system for use with patient pain drawings","volume":"24","author":"RB Margolis","year":"1986","journal-title":"Pain"},{"key":"pone.0254862.ref006","first-page":"45","volume-title":"The McGill Pain Questionnaire: Development, psychometric properties, and usefulness of the long form, short form, and short form-2. Handbook of pain assessment","author":"J Katz","year":"2011","edition":"3"},{"issue":"5","key":"pone.0254862.ref007","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1097\/00002508-200409000-00005","article-title":"Validity of the brief pain inventory for use in documenting the outcomes of patients with noncancer pain","volume":"20","author":"S Keller","year":"2004","journal-title":"Clin J Pain"},{"issue":"10","key":"pone.0254862.ref008","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1097\/j.pain.0000000000001899","article-title":"The Graphical Index of Pain: a new web-based method for high-throughput screening of pain","volume":"161","author":"OA Steingrimsdottir","year":"2020","journal-title":"Pain"},{"issue":"1","key":"pone.0254862.ref009","doi-asserted-by":"crossref","first-page":"16522","DOI":"10.1038\/s41598-018-34950-2","article-title":"Distinct patterns of variation in the distribution of knee pain","volume":"8","author":"SA 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Standard Care.","volume":"21","author":"A Gillman","year":"2020","journal-title":"Pain medicine (Malden, Mass)."},{"issue":"11","key":"pone.0254862.ref027","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1001\/jama.2021.2104","article-title":"The Reporting of Race and Ethnicity in Medical and Science Journals: Comments Invited","volume":"325","author":"A Flanagin","year":"2021","journal-title":"JAMA"},{"issue":"5","key":"pone.0254862.ref028","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A new method of classifying prognostic comorbidity in longitudinal studies: development and validation","volume":"40","author":"ME Charlson","year":"1987","journal-title":"J Chronic Dis"},{"issue":"11","key":"pone.0254862.ref029","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/0895-4356(94)90129-5","article-title":"Validation of a combined comorbidity index.","volume":"47","author":"M Charlson","year":"1994","journal-title":"J Clin Epidemiol."},{"issue":"3","key":"pone.0254862.ref030","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.pain.2003.08.001","article-title":"Core outcome domains for chronic pain clinical trials: IMMPACT recommendations","volume":"106","author":"DC Turk","year":"2003","journal-title":"Pain"},{"issue":"5 Suppl 1","key":"pone.0254862.ref031","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1097\/01.mlr.0000258615.42478.55","article-title":"The Patient-Reported Outcomes Measurement Information System (PROMIS): progress of an NIH Roadmap cooperative group during its first two years.","volume":"45","author":"D Cella","year":"2007","journal-title":"Med Care"},{"issue":"11","key":"pone.0254862.ref032","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/j.jclinepi.2010.04.011","article-title":"The Patient-Reported Outcomes Measurement Information System (PROMIS) developed and tested its first wave of adult self-reported health outcome item banks: 2005\u20132008.","volume":"63","author":"D Cella","year":"2010","journal-title":"J Clin Epidemiol."},{"issue":"1","key":"pone.0254862.ref033","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3899\/jrheum.130813","article-title":"Item response theory, computerized adaptive testing, and PROMIS: assessment of physical function","volume":"41","author":"JF Fries","year":"2014","journal-title":"J Rheumatol"},{"key":"pone.0254862.ref034","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jclinepi.2015.08.038","article-title":"PROMIS measures of pain, fatigue, negative affect, physical function, and social function demonstrated clinical validity across a range of chronic conditions.","volume":"73","author":"KF Cook","year":"2016","journal-title":"J Clin Epidemiol."},{"issue":"9","key":"pone.0254862.ref035","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1007\/s11136-010-9694-5","article-title":"Patient-reported outcomes measurement information system (PROMIS) domain names and definitions revisions: further evaluation of content validity in IRT-derived item banks.","volume":"19","author":"WT Riley","year":"2010","journal-title":"Qual Life Res"},{"issue":"1","key":"pone.0254862.ref036","doi-asserted-by":"crossref","first-page":"e784","DOI":"10.1097\/PR9.0000000000000784","article-title":"Clinical outcome assessment in clinical trials of chronic pain treatments","volume":"6","author":"KV Patel","year":"2021","journal-title":"Pain reports"},{"issue":"3","key":"pone.0254862.ref037","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1016\/j.jpain.2017.12.128","article-title":"The somatic distribution of chronic pain and emotional distress utilizing the collaborative health outcomes information registry (CHOIR) bodymap.","volume":"19","author":"E Cramer","year":"2018","journal-title":"The Journal of Pain."},{"issue":"4","key":"pone.0254862.ref038","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1016\/j.jpain.2015.01.042","article-title":"(128) Somatic distributions of pain characterized with a pain registry (CHOIR).","volume":"16","author":"K Johnson","year":"2015","journal-title":"The Journal of Pain."},{"issue":"1","key":"pone.0254862.ref039","doi-asserted-by":"crossref","first-page":"e880","DOI":"10.1097\/PR9.0000000000000880","article-title":"Development and validation of the Collaborative Health Outcomes Information Registry body map","volume":"6","author":"KH Scherrer","year":"2021","journal-title":"Pain reports"},{"issue":"10","key":"pone.0254862.ref040","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1185\/030079906X132488","article-title":"painDETECT: a new screening questionnaire to identify neuropathic components in patients with back pain","volume":"22","author":"R Freynhagen","year":"2006","journal-title":"Curr Med Res Opin"},{"issue":"7\u20138","key":"pone.0254862.ref041","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.jpain.2019.11.013","article-title":"Test-Retest and Inter-Examiner Reliability of a Novel Bedside Quantitative Sensory Testing Battery in Postherpetic Neuralgia Patients.","volume":"21","author":"AD Wasan","year":"2020","journal-title":"J Pain"},{"issue":"6","key":"pone.0254862.ref042","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1185\/03007995.2016.1157460","article-title":"The painDETECT project\u2014far more than a screening tool on neuropathic pain","volume":"32","author":"R Freynhagen","year":"2016","journal-title":"Curr Med Res Opin"},{"issue":"1","key":"pone.0254862.ref043","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.pain.2010.04.025","article-title":"Development of a PROMIS item bank to measure pain interference","volume":"150","author":"D Amtmann","year":"2010","journal-title":"Pain"},{"issue":"7","key":"pone.0254862.ref044","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1007\/s11136-009-9496-9","article-title":"Development of physical and mental health summary scores from the patient-reported outcomes measurement information system (PROMIS) global items.","volume":"18","author":"RD Hays","year":"2009","journal-title":"Qual Life Res."},{"key":"pone.0254862.ref045","article-title":"An elementary mathematical theory of classification and prediction","author":"T. Tanimoto","year":"1958","journal-title":"IBM Internal Report."},{"issue":"3","key":"pone.0254862.ref046","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0306-4573(89)90048-4","article-title":"Similarity measures in scientometric research: the Jaccard Index versus Salton\u2019s Cosine Formula","volume":"25","author":"L Hamers","year":"1989","journal-title":"Information Processing and Management"},{"issue":"5","key":"pone.0254862.ref047","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1093\/pm\/pnx079","article-title":"Operationalizing Multidisciplinary Assessment and Treatment as a Quality Metric for Interventional Pain Practices.","volume":"19","author":"EK Heres","year":"2018","journal-title":"Pain medicine (Malden, Mass)."},{"key":"pone.0254862.ref048","volume-title":"R: A language and environment for statistical computing.","author":"Team RC","year":"2019"},{"issue":"11","key":"pone.0254862.ref049","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1097\/j.pain.0000000000001324","article-title":"Evaluation of composite responder outcomes of pain intensity and physical function in neuropathic pain clinical trials: an ACTTION individual patient data analysis","volume":"159","author":"KV Patel","year":"2018","journal-title":"Pain"},{"issue":"3","key":"pone.0254862.ref050","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/AAP.0b013e31828ea086","article-title":"Epidural steroids: a comprehensive, evidence-based review.","volume":"38","author":"SP Cohen","year":"2013","journal-title":"Reg Anesth Pain Med."},{"issue":"8","key":"pone.0254862.ref051","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1097\/j.pain.0000000000000492","article-title":"Neuropathic pain: an updated grading system for research and clinical practice","volume":"157","author":"NB Finnerup","year":"2016","journal-title":"Pain"},{"issue":"5","key":"pone.0254862.ref052","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1097\/j.pain.0000000000002134","article-title":"A picture is worth a thousand words: linking fibromyalgia pain widespreadness from digital pain drawings with pain catastrophizing and brain cross-network connectivity","volume":"162","author":"DM Ellingsen","year":"2021","journal-title":"Pain"},{"issue":"2","key":"pone.0254862.ref053","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.pain.2013.10.023","article-title":"Sensory profiles of patients with neuropathic pain based on the neuropathic pain symptoms and signs","volume":"155","author":"R Freeman","year":"2014","journal-title":"Pain"},{"issue":"9","key":"pone.0254862.ref054","doi-asserted-by":"crossref","first-page":"e74873","DOI":"10.1371\/journal.pone.0074873","article-title":"Cluster analysis of clinical data identifies fibromyalgia subgroups.","volume":"8","author":"E Docampo","year":"2013","journal-title":"PLoS One."},{"issue":"5","key":"pone.0254862.ref055","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1186\/s13075-014-0463-7","article-title":"OMERACT-based fibromyalgia symptom subgroups: an exploratory cluster analysis.","volume":"16","author":"A Vincent","year":"2014","journal-title":"Arthritis Res Ther"},{"issue":"1","key":"pone.0254862.ref056","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13075-018-1532-0","article-title":"Longitudinal stability of fibromyalgia symptom clusters.","volume":"20","author":"TL Hoskin","year":"2018","journal-title":"Arthritis Res Ther"},{"issue":"2","key":"pone.0254862.ref057","doi-asserted-by":"crossref","first-page":"e0192623","DOI":"10.1371\/journal.pone.0192623","article-title":"Chronic pain patients can be classified into four groups: Clustering-based discriminant analysis of psychometric data from 4665 patients referred to a multidisciplinary pain centre (a SQRP study).","volume":"13","author":"E Backryd","year":"2018","journal-title":"PLoS One."},{"issue":"2","key":"pone.0254862.ref058","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/j.pain.0000000000000753","article-title":"Peripheral neuropathic pain: a mechanism-related organizing principle based on sensory profiles","volume":"158","author":"R Baron","year":"2017","journal-title":"Pain"},{"issue":"11","key":"pone.0254862.ref059","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1016\/j.pain.2014.08.014","article-title":"The effect of oxcarbazepine in peripheral neuropathic pain depends on pain phenotype: a randomised, double-blind, placebo-controlled phenotype-stratified study","volume":"155","author":"DT Demant","year":"2014","journal-title":"Pain"},{"issue":"7","key":"pone.0254862.ref060","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/s41582-020-0362-2","article-title":"Discovery and validation of biomarkers to aid the development of safe and 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