{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:29:22Z","timestamp":1787729362260,"version":"build-2784847793"},"reference-count":28,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T00:00:00Z","timestamp":1632441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>\n                    PMR is a common inflammatory rheumatic disease. Although its clinical characteristics are fully recognized, no specific test for its diagnosis has been established to date. Several studies have described a wide variety of diseases that present with polymyalgic symptoms. A\n                    <jats:sup>18<\/jats:sup>\n                    FDG-PET\/CT scan could help to deal with these differential diagnoses. The goal of our study is to describe the findings of the\n                    <jats:sup>18<\/jats:sup>\n                    FDG-PET\/CT scan in a cohort of PMR patients and to detail how the\n                    <jats:sup>18<\/jats:sup>\n                    FDG-PET\/CT scan improves accuracy when diagnosing other underlying conditions. This cross-sectional study enrolled patients with a diagnosis of PMR who underwent to a\n                    <jats:sup>18<\/jats:sup>\n                    FDG-PET\/CT scan to rule out other diagnosis. The\n                    <jats:sup>18<\/jats:sup>\n                    FDG-PET\/CT scan was performed either following clinical criteria at the onset of clinical symptoms or when the patient became PMR steroid resistant. Patients\u2019 demographic, clinical and analytical data at the moment of the\n                    <jats:sup>18<\/jats:sup>\n                    FDG-PET\/CT scan were recorded. The final diagnosis was confirmed according to clinical judgement. A total of 103 patients with PMR were included. In 49.51% of patients, the\n                    <jats:sup>18<\/jats:sup>\n                    FDG-PET\/CT scan was ordered to study resistance to steroid therapy. The final diagnoses of patients were PMR in 70.9% patients, large vessel vasculitis in 15.5%, neoplasms 4.8% and another diagnosis in the rest. The\n                    <jats:sup>18<\/jats:sup>\n                    FDG-PET\/CT scan is a very useful technique for the study of Polymyalgia Rheumatica, not only to help in the diagnostic process, but also due to its role in the identification of a variety of PMR-like patrons.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0255131","type":"journal-article","created":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T13:39:51Z","timestamp":1632490791000},"page":"e0255131","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["\"The added value of 18f-FDG PET\/CT in the assessment of onset and steroid resistant polimyalgia rheumatica\""],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8339-5420","authenticated-orcid":true,"given":"Patricia","family":"Moya-Alvarado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Fernandez Leon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Emilia","family":"Corica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valle","family":"Camacho Marti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego Alfonso","family":"L\u00f3pez-Mora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5410-5807","authenticated-orcid":true,"given":"Ivan","family":"Castellv\u00ed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7738-6787","authenticated-orcid":true,"given":"H\u00e8ctor","family":"Corominas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,9,24]]},"reference":[{"key":"pone.0255131.ref001","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1016\/S0140-6736(17)31825-1","article-title":"Polymyalgia rheumatica","volume":"390","author":"MA Gonz\u00e1lez-Gay","year":"2017","journal-title":"Lancet"},{"key":"pone.0255131.ref002","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.ejim.2013.03.003","article-title":"Update on polymyalgia rheumatica","volume":"24","author":"N Pipitone","year":"2013","journal-title":"Eur J Intern Med"},{"key":"pone.0255131.ref003","first-page":"276","article-title":"Diagnostic approach in a patient presenting with polymyalgia","volume":"17","author":"MA Gonzalez-Gay","year":"1999","journal-title":"Clin Exp Rheumatol"},{"key":"pone.0255131.ref004","first-page":"2179","article-title":"The spectrum of conditions mimicking polymyalgia rheumatica in Northwestern Spain","volume":"27","author":"MA Gonzalez-Gay","year":"2000","journal-title":"J Rheumatol"},{"key":"pone.0255131.ref005","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1002\/art.1780280905","article-title":"The clinical features of elderly-onset rheumatoid arthritis. 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Rheumatol"},{"key":"pone.0255131.ref023","doi-asserted-by":"crossref","first-page":"629","DOI":"10.5507\/bp.2015.026","article-title":"Various forms of 18F-FDG PET and PET\/CT findings in patients with polymyalgia rheumatica","volume":"159","author":"Z Rehak","year":"2015","journal-title":"Biomed Pap"},{"key":"pone.0255131.ref024","doi-asserted-by":"crossref","first-page":"705","DOI":"10.3109\/s10165-011-0581-x","article-title":"Whole-body fluorodeoxyglucose positron emission tomography\/computed tomography in patients with active polymyalgia rheumatica: evidence for distinctive bursitis and large-vessel vasculitis","volume":"22","author":"H Yamashita","year":"2012","journal-title":"Mod Rheumatol"},{"key":"pone.0255131.ref025","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1093\/rheumatology\/kew202","article-title":"Utility of 18F-fluoro-dexoxyglucose positron emission tomography for the diagnosis of polymyalgia rheumatica: a controlled study","volume":"55","author":"M Sondag","year":"2016","journal-title":"Rheumatology (Oxford)"},{"key":"pone.0255131.ref026","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s12149-018-1269-5","article-title":"Diagnosing polymyalgia rheumatica on 18F-FDG PET\/CT: typical uptake patterns","volume":"32","author":"S Yuge","year":"2018","journal-title":"Ann Nucl Med"},{"key":"pone.0255131.ref027","first-page":"1","article-title":"Differences of articular and extra-articular involvement in polymyalgia rheumatica: A comparison by whole-body FDG-PET\/CT","volume":"7","author":"K Kaneko","year":"2019","journal-title":"Mod Rheumatol"},{"key":"pone.0255131.ref028","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1093\/rheumatology\/ket229","article-title":"High frequency of capsular knee involvement in polymyalgia rheumatica\/giant cell arteritis patients studied by positron emission tomography","volume":"52","author":"MA Cimmino","year":"2013","journal-title":"Rheumatology (Oxford)"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0255131","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T13:40:17Z","timestamp":1632490817000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0255131"}},"subtitle":[],"editor":[{"given":"Pierpaolo","family":"Alongi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,9,24]]},"references-count":28,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2021,9,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0255131","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.04.28.21256259","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,24]]}}}