{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T13:38:23Z","timestamp":1758893903566,"version":"3.40.5"},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T00:00:00Z","timestamp":1629417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ministry of health & welfare, republic of korea","award":["HI21C1251"],"award-info":[{"award-number":["HI21C1251"]}]},{"DOI":"10.13039\/501100003725","name":"National research foundation of Korea","doi-asserted-by":"crossref","award":["2018R1C1B5085620"],"award-info":[{"award-number":["2018R1C1B5085620"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Purpose<\/jats:title>\n<jats:p>We sought to evaluate changes of mean peripapillary choroidal thickness (PCT) and subfoveal choroidal thickness (SFCT) over 12 months in patients with unilateral central retinal vein occlusion (CRVO).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Our retrospective, observational study included 19 patients with treatment-na\u00efve, unilateral CRVO who completed at least 12 months of follow-up period. Mean PCT and mean SFCT in CRVO-affected eyes and unaffected contralateral eyes were measured at each follow-up visit, and then compared. Differences between baseline and 12 months (\u0394SFCT and \u0394PCT) and percentage changes (\u0394SFCT or \u0394PCT\/baseline\u00d7100%) were determined. We also investigated the predictive factors for visual outcome in the CRVO-affected eyes.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>In the CRVO-affected eyes, mean PCT was 146.7\u00b141.9 \u03bcm at baseline, and 106.5\u00b124.2 \u03bcm at 12 months (P &lt; 0.001). Mean PCT of the contralateral eyes was 129.8\u00b142.6 \u03bcm at baseline and 124.6\u00b139.7 \u03bcm at 12 months (P = 0.089). Mean SFCT of CRVO-affected eyes was 225.8\u00b177.9 \u03bcm at baseline, and 199.4\u00b166.6 \u03bcm at 12 months (P = 0.009). Mean SFCT of the contralateral eyes was 218.4\u00b183.0 \u03bcm at baseline, and 208.4\u00b178.1 \u03bcm at 12 months (P = 0.089). \u0394 PCT was -41.6\u00b125.3 \u03bcm in the CRVO-affected eyes, and -5.2\u00b15.8 \u03bcm in the contralateral eyes (P&lt;0.001). % PCT was -24.9\u00b114.0% in the CRVO-affected eyes, and -4.0\u00b10.4% in the contralateral eyes (P = 0.001). \u0394 SFCT was -26.4\u00b124.6 \u03bcm in the CRVO-affected eyes, and -9.5\u00b116.7\u03bcm in the contralateral eyes (P = 0.016). % SFCT was -10.4\u00b19.8% in the CRVO-affected eyes, and -3.4\u00b16.4% in the contralateral eyes (P = 0.015). Among the various factors, BCVA at baseline (\u03b2 = 0.797, P = 0.001) and % SFCT (\u03b2 = 0.712, P = 0.001) were significantly associated with visual outcome at 12 months in the CRVO-affected eyes.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Both peripapillary and subfoveal choroidal thickness reduced significantly over 12 months in the CRVO-affected eyes, but not in the contralateral eyes. In addition, the absolute reduction amount and reduction ratio of PCT and SFCT were significantly greater in the CRVO-affected eyes than the contralateral eyes.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0255182","type":"journal-article","created":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T18:31:35Z","timestamp":1629484295000},"page":"e0255182","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Changes in peripapillary and subfoveal choroidal thickness in patients with central retinal vein occlusion"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7675-0180","authenticated-orcid":true,"given":"Hae Min","family":"Kang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong Hoon","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyoung Jun","family":"Koh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Chul","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2021,8,20]]},"reference":[{"key":"pone.0255182.ref001","volume-title":"Ryan\u2019s Retina","author":"P Oellers","year":"2018","edition":"6"},{"issue":"1","key":"pone.0255182.ref002","first-page":"40","article-title":"Retinal vein occlusion Review","volume":"7","author":"M Ip","year":"2018","journal-title":"Asia Pac J Ophthalmol (phila)"},{"issue":"5","key":"pone.0255182.ref003","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1001\/archopht.1996.01100130537006","article-title":"Risk factors for central retinal vein occlusion. 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