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We investigated the acute effects of a 50 Hz sinusoidal MF at <jats:italic>B<\/jats:italic><jats:sub>max<\/jats:sub> 180 mT on hemodynamics, electrocardiogram, and vascular endothelial function in healthy young men. Three types of regional exposures to a 50 Hz MF, i.e., forearm, upper arm, or neck exposure to MF were performed. Participants who received three types of real MF exposures had significantly increased ulnar arterial blood flow velocity compared to the sham exposures. Furthermore, after muscle loading exercise, MF exposure recovered hemoglobin oxygenation index values faster and higher than sham exposure from the loading condition. Moreover, participants who received real MF exposure in the neck region had significantly increased parasympathetic high-frequency activity relative to the sham exposure. The MF exposure in the upper arm region significantly increased the brachial artery flow-mediated dilation compared to the sham exposure. Computer simulations of induced <jats:italic>in situ<\/jats:italic> electric fields indicated that the order-of-magnitude estimates of the peak values were 100\u2013500 mV\/m, depending on the exposure conditions. This study provides the first evidence that a 50 Hz MF can activate parasympathetic activity and thereby lead to increase vasodilation and blood flow via a nitric oxide-dependent mechanism.<\/jats:p>\n<jats:p><jats:bold>Trial registration:<\/jats:bold> UMIN Clinical Trial Registry (CTR) <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/upload.umin.ac.jp\/cgi-open-bin\/ctr_e\/ctr_view.cgi?recptno=R000044252\" xlink:type=\"simple\">UMIN000038834<\/jats:ext-link>. The authors confirm that all ongoing and related trials for this drug\/intervention are registered.<\/jats:p>","DOI":"10.1371\/journal.pone.0255242","type":"journal-article","created":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T20:09:59Z","timestamp":1628194199000},"page":"e0255242","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["A 50 Hz magnetic field affects hemodynamics, ECG and vascular endothelial function in healthy adults: A pilot randomized controlled trial"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3520-5164","authenticated-orcid":true,"given":"Hideyuki","family":"Okano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akikatsu","family":"Fujimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsukasa","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilkka","family":"Laakso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromi","family":"Ishiwatari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichi","family":"Watanuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2021,8,5]]},"reference":[{"issue":"2","key":"pone.0255242.ref001","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s00223-019-00554-9","article-title":"The response of osteoblasts and bone to sinusoidal electromagnetic fields: insights from the literature","volume":"105","author":"C Galli","year":"2019","journal-title":"Calcif Tissue Int"},{"key":"pone.0255242.ref002","first-page":"351","volume-title":"Mechanisms and Therapeutic Applications of Time-varying and Static Magnetic Fields.","author":"AA Pilla","year":"2007","edition":"3"},{"issue":"1","key":"pone.0255242.ref003","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3233\/BMR-2000-15103","article-title":"Magnetic and electromagnetic field therapy.","volume":"15","author":"MS Markov","year":"2000","journal-title":"J Back Musculoskelet Rehabil"},{"issue":"2","key":"pone.0255242.ref004","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1159\/000093061","article-title":"Effects of electromagnetic fields on cells: physiological and therapeutical approaches and molecular mechanisms of interaction. 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