{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T06:16:12Z","timestamp":1764656172115,"version":"3.37.3"},"reference-count":27,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T00:00:00Z","timestamp":1628467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"crossref","award":["no. 2018YQ51"],"award-info":[{"award-number":["no. 2018YQ51"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["no.43172004138"],"award-info":[{"award-number":["no.43172004138"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>The purpose of this study is to investigate and analyze the prevalence and influencing factors of stroke in hypertensive patients aged 60 and above in Jiading District, Shanghai.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>The population-based study included 18,724 screened people with hypertension (age \u2265 60 years, 48.7% women). From 2016 to 2019, data on demographics, potential influencing factors and health status were collected through face-to-face interviews, physical examinations, and laboratory tests. Logistic multivariate logistic regression model was used to analyze the influencing factors associated with stroke.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Among the object of study from 2016 to 2019, 2,025 patients were screened for stroke, with the overall prevalence rate of 10.82% (10.41%-11.23%). Multivariate adjusted model analysis showed that dyslipidemia (OR:1.31,95%CI:1.19\u20131.45), lack of exercise (OR:1.91,95%CI:1.32\u20132.76), atrial fibrillation [OR:1.49,95%CI:1.35\u20131.65), family history of stroke (OR:2.18,95%CI:1.6\u20132.88) were the significant independent influencing factors of stroke in hypertensive patients over 60 years old. When these four factors were combined, compared with participants without any of these factors, the multi-adjusted odds ratios (95% confidence interval) of risk of stroke for persons concurrently having one, two and three or more of these factors were 1.89 (1.67\u20132.13), 2.15 (1.86\u20132.47) and 6.84 (4.90\u20139.55), respectively (linear trend P &lt; 0.001); after multivariate adjustment, the family history of stroke had additive interaction with lack of exercise [RERI = 1.08(0.22\u20131.94), AP = 0.19(0.04\u20130.35), S = 1.31(1.02\u20131.69)], dyslipidemia [RERI = 0.87(0.41\u20131.33), AP = 0.23(0.08\u20130.38), S = 1.46(1.04\u20132.05)].<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>The prevalence of stroke was high in hypertensive patients aged 60 and above in Jiading District, Shanghai. Dyslipidemia, lack of exercise, atrial fibrillation and family history of stroke were significantly associated with stroke in hypertensive population. Stroke risk can be increased especially when multiple factors coexisting, and family history of stroke combined with a lack of exercise or dyslipidemia.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0255279","type":"journal-article","created":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T18:16:02Z","timestamp":1628532962000},"page":"e0255279","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Analysis of prevalence and influencing factors of stroke in elderly hypertensive patients: Based on the screening plan for the high-risk population of stroke in Jiading District, Shanghai"],"prefix":"10.1371","volume":"16","author":[{"given":"Jiefeng","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunlin","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangfeng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fen","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2021,8,9]]},"reference":[{"key":"pone.0255279.ref001","doi-asserted-by":"crossref","first-page":"100870","DOI":"10.1016\/j.yfrne.2020.100870","article-title":"Sex matters in stroke: a review of recent evidence on the differences between women and men","author":"C Carcel","year":"2020","journal-title":"Front Neuroendocrinol"},{"issue":"2","key":"pone.0255279.ref002","first-page":"106","article-title":"Study on the risk factors among stroke in young people.","volume":"24","author":"Beijing Neurdogist Club","year":"2003","journal-title":";Zhonghua Liu Xing Bing Xue Za Zhi"},{"issue":"2","key":"pone.0255279.ref003","first-page":"260","article-title":"Epidemiology and Primary Prevention of Stroke.","volume":"26","author":"K Furie","year":"2020","journal-title":"Continuaum (Minneap Minn)"},{"issue":"16","key":"pone.0255279.ref004","doi-asserted-by":"crossref","first-page":"e19689","DOI":"10.1097\/MD.0000000000019689","article-title":"The population attributable risk and clustering of stroke risk factor in different economical regions of China","volume":"99","author":"S Dong","year":"2020","journal-title":"Medicine (Baltimore)"},{"journal-title":"China Healthcare & Nutrition","article-title":"The Nutrition and Health Status of the Chinese People[J]","year":"2004","key":"pone.0255279.ref005"},{"issue":"47","key":"pone.0255279.ref006","article-title":"Technical Specifications for Stroke Screening and Prevention","volume":"3","author":"Stroke Screening and Prevention Engineering Committee of the National Health and Family Planning Commission","year":"2014","journal-title":"Chinese Journal of Neurology"},{"issue":"1","key":"pone.0255279.ref007","first-page":"113","article-title":"Cerebrovascular disease in the community: results of a WHO collaborative study[J]","volume":"58","author":"K Aho","year":"1980","journal-title":"Bull World Health Organ"},{"key":"pone.0255279.ref008","volume-title":"Modern epidemiology.","author":"KJ Rothman","year":"1992","edition":"2"},{"issue":"2","key":"pone.0255279.ref009","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s00038-004-0044-7","article-title":"Interaction and evolution in epidemiology","volume":"49","author":"KJ Rothman","year":"2004","journal-title":"Soz Praventivmed"},{"key":"pone.0255279.ref010","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1097\/00001648-199209000-00012","article-title":"Confidence interval estimation of interaction","volume":"3","author":"DW Hosmer","year":"1992","journal-title":"Epidemiology"},{"issue":"7","key":"pone.0255279.ref011","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s10654-005-7835-x","article-title":"Calculating measures of biological interaction","volume":"20","author":"T Andersson","year":"2005","journal-title":"Eur J Epidemiol"},{"key":"pone.0255279.ref012","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1093\/aje\/kwn411","article-title":"Estimation of the relative excess risk due to interaction and associated confidence bounds.","volume":"169","author":"D.B. 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