{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:30:56Z","timestamp":1790857856794,"version":"4.1.0"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T00:00:00Z","timestamp":1627516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006439","name":"Faculty of Tropical Medicine, Mahidol University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006439","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Delayed plasma leakage recognition could lead to improper fluid administration resulting in dengue shock syndrome, subsequently, multi-organ failure, and death. This prospective observational study was conducted in Bangkok, Thailand, between March 2018 and February 2020 to determine predictors of plasma leakage and develop a plasma leakage predictive score among dengue patients aged \u226515 years. Of 667 confirmed dengue patients, 318 (47.7%) developed plasma leakage, and 349 (52.3%) had no plasma leakage. Multivariate analysis showed three independent factors associated with plasma leakage, including body mass index \u226525.0 kg\/m<jats:sup>2<\/jats:sup> (odds ratio [OR] = 1.784; 95% confidence interval [CI] = 1.040\u20133.057; P = 0.035), platelet count &lt;100,000\/mm<jats:sup>3<\/jats:sup> on fever days 3 to 4 (OR = 2.151; 95% CI = 1.269\u20133.647; P = 0.004), and aspartate aminotransferase or alanine aminotransferase \u2265100 U\/l on fever days 3 to 4 (OR = 2.189; 95% CI = 1.231\u20133.891; P = 0.008). Because these three parameters had evidence of equality, each independent factor was weighted to give a score of 1 with a total plasma-leak score of 3. Higher scores were associated with increased plasma leakage occurrence, with ORs of 2.017 (95% CI = 1.052\u20133.869; P = 0.035) for score 1, 6.158 (95% CI = 2.914\u201313.015; P &lt;0.001) for score 2, and 6.300 (95% CI = 2.419\u201316.407; P &lt;0.001) for score 3. The area under the receiver operating characteristics curves for predicting plasma leakage was good (0.677 [95% CI = 0.616\u20130.739]). Patients with a plasma-leak score \u22651 had high sensitivity (88.8%), and those with a plasma-leak score of 3 had high specificity (93.4%) for plasma leakage occurrence. This simple and easily accessible clinical score might help physicians provide early and timely appropriate clinical dengue management in endemic areas.<\/jats:p>","DOI":"10.1371\/journal.pone.0255358","type":"journal-article","created":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T18:28:20Z","timestamp":1627583300000},"page":"e0255358","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["Predictors of plasma leakage among dengue patients in Thailand: A plasma-leak score analysis"],"prefix":"10.1371","volume":"16","author":[{"given":"Sutopa","family":"Talukdar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5377-1955","authenticated-orcid":true,"given":"Vipa","family":"Thanachartwet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6184-072X","authenticated-orcid":true,"given":"Varunee","family":"Desakorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supat","family":"Chamnanchanunt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duangjai","family":"Sahassananda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukda","family":"Vangveeravong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siripen","family":"Kalayanarooj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anan","family":"Wattanathum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,7,29]]},"reference":[{"issue":"7446","key":"pone.0255358.ref001","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature12060","article-title":"The global distribution and burden of dengue","volume":"496","author":"S Bhatt","year":"2013","journal-title":"Nature"},{"issue":"12","key":"pone.0255358.ref002","doi-asserted-by":"crossref","first-page":"e0226945","DOI":"10.1371\/journal.pone.0226945","article-title":"The association between dengue incidences and provincial-level weather variables in Thailand from 2001 to 2014.","volume":"14","author":"R Chumpu","year":"2019","journal-title":"PLOS ONE."},{"issue":"5","key":"pone.0255358.ref003","doi-asserted-by":"crossref","first-page":"e0004575","DOI":"10.1371\/journal.pntd.0004575","article-title":"A two-year review on epidemiology and clinical characteristics of dengue deaths in Malaysia, 2013\u20132014.","volume":"10","author":"YL Woon","year":"2016","journal-title":"PLOS Negl Trop Dis"},{"key":"pone.0255358.ref004","volume-title":"Global strategy for dengue prevention and control 2012\u20132020","author":"World Health Organization (WHO)","year":"2012"},{"issue":"Suppl 4","key":"pone.0255358.ref005","doi-asserted-by":"crossref","first-page":"83","DOI":"10.2149\/tmh.2011-S10","article-title":"Clinical manifestations and management of dengue\/DHF\/DSS","volume":"39","author":"S. 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