{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T09:34:49Z","timestamp":1774085689976,"version":"3.50.1"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T00:00:00Z","timestamp":1627862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010101","name":"Taichung Veterans General Hospital","doi-asserted-by":"crossref","award":["TCVGH-1106901B"],"award-info":[{"award-number":["TCVGH-1106901B"]}],"id":[{"id":"10.13039\/501100010101","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objective<\/jats:title>\n<jats:p>To evaluate whether the risk of subsequent psoriasis and psoriatic arthritis development is increased in patients with uveitis.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>In Taiwan\u2019s national health insurance research database, we identified 195,125 patients with new-onset uveitis between 2001 and 2013. We randomly selected 390,250 individuals without uveitis who were matched 2:1 to uveitis cases based on age, sex and year of enrolment. The characteristics of the two groups were compared. Using multivariate Cox regression, hazard ratios (HRs) for psoriasis or psoriatic arthritis corresponding to uveitis were computed after adjustment for age, sex, insurance cost and comorbidities. In subgroup analyses, separate HRs for mild psoriasis, severe psoriasis and psoriatic arthritis were calculated.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>The mean age of the study cohort was 50.2 \u00b1 17.2 years. Hypertension, diabetes, hyperlipidaemia and obesity were more prevalent in the uveitis group (all <jats:italic>p<\/jats:italic> &lt; 0.0001). The hazard of psoriasis or psoriatic arthritis development was significantly greater in the uveitis group than in the non-uveitis group (<jats:italic>p<\/jats:italic> &lt; 0.0001); this increased risk persisted after adjustment for confounders [adjusted HR = 1.41; 95% confidence interval (CI), 1.33\u20131.48]. Adjusted HRs showed an increasing trend from mild psoriasis (1.35; 95% CI, 1.28\u20131.44) to severe psoriasis (1.59; 95% CI, 1.30\u20131.94) and psoriatic arthritis (1.97; 95% CI, 1.60\u20132.42).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>This nationwide population-based cohort study revealed that patients with uveitis have an increased risk of subsequent psoriasis or psoriatic arthritis development.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0255492","type":"journal-article","created":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T17:29:10Z","timestamp":1627925350000},"page":"e0255492","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["The risk of psoriasis in patients with uveitis: A nationwide population-based cohort study"],"prefix":"10.1371","volume":"16","author":[{"given":"Yu-Yen","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsin-Hua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzu-Chen","family":"Lo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pesus","family":"Chou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2021,8,2]]},"reference":[{"issue":"2","key":"pone.0255492.ref001","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.clim.2011.01.014","article-title":"Cytokine profiles in aqueous humor of patients with different clinical entities of endogenous uveitis","volume":"139","author":"AM El-Asrar","year":"2011","journal-title":"Clinical immunology (Orlando, 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Possible mechanism of the association of psoriasis and anterior uveitis","volume":"193","author":"S Iijima","year":"1996","journal-title":"Dermatology (Basel, Switzerland)"},{"issue":"7","key":"pone.0255492.ref034","first-page":"1175","article-title":"Clinical features of psoriatic uveitis in Japanese patients. Graefe\u2019s archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle","volume":"253","author":"R Tanaka","year":"2015","journal-title":"Ophthalmologie"},{"key":"pone.0255492.ref035","doi-asserted-by":"crossref","first-page":"e14451","DOI":"10.1111\/dth.14451","article-title":"Moderate-to-severe plaque psoriasis, described by pasi \u226510%, can be associated with higher cardiovascular risk according to seven risk algorithms: Results of a 10-year single-center retrospective study and clinical management of psoriatic patients with cardiovascular risk","volume":"33","author":"C. Conforti","year":"2020","journal-title":"Dermatologic therapy"},{"issue":"3","key":"pone.0255492.ref036","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.jdermsci.2015.03.012","article-title":"Risk of incident chronic kidney disease and end-stage renal disease in patients with psoriasis: A nationwide population-based cohort study","volume":"78","author":"CC Chi","year":"2015","journal-title":"Journal of dermatological science"},{"issue":"1","key":"pone.0255492.ref037","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jdermsci.2011.03.002","article-title":"Epidemiology and comorbidities of psoriasis patients in a national database in Taiwan","volume":"63","author":"TF Tsai","year":"2011","journal-title":"Journal of dermatological science"},{"issue":"5","key":"pone.0255492.ref038","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1111\/j.1365-2133.2011.10494.x","article-title":"Medical comorbidity associated with psoriasis in adults: a population-based study","volume":"165","author":"YW Yang","year":"2011","journal-title":"The British journal of dermatology"},{"key":"pone.0255492.ref039","first-page":"f5961","article-title":"Risk of moderate to advanced kidney disease in patients with psoriasis: population based cohort study","volume":"347","author":"J Wan","year":"2013","journal-title":"BMJ (Clinical research ed)"},{"issue":"1","key":"pone.0255492.ref040","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/bjd.13599","article-title":"Increased risk of glomerulonephritis and chronic kidney disease in relation to the severity of psoriasis, concomitant medication, and comorbidity: a nationwide population-based cohort study","volume":"173","author":"HY Chiu","year":"2015","journal-title":"The British journal of dermatology"},{"issue":"3","key":"pone.0255492.ref041","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1111\/bjd.12731","article-title":"Psoriasis and uveitis\u2014should we be asking about eye symptoms?","volume":"170","author":"E Burden-Teh","year":"2014","journal-title":"The British journal of dermatology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0255492","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T17:29:52Z","timestamp":1627925392000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0255492"}},"subtitle":[],"editor":[{"given":"Luca","family":"Navarini","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,8,2]]},"references-count":41,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2021,8,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0255492","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,2]]}}}