{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:49:10Z","timestamp":1790650150459,"version":"4.1.0"},"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T00:00:00Z","timestamp":1628121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"japan grant-in-aid for scientific research","award":["20K08777"],"award-info":[{"award-number":["20K08777"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Adult-onset Still\u2019s disease (AOSD) is a systemic autoinflammatory disease in which danger-associated molecular patterns (DAMPs)-mediated inflammasome activation seems to be involved in the disease pathogenesis. Cold-inducible RNA-binding protein (CIRP) belongs to a family of cold-shock proteins that respond to cellular stress and has been identified as a DAMP that triggers the inflammatory response. The aim of this study is to investigate the clinical significance of serum CIRP levels in AOSD.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Serum samples were obtained from 44 patients with active AOSD or 50 patients with rheumatoid arthritis (RA), 20 patients with systemic lupus erythematosus (SLE), and 15 healthy control patients (HCs). Serum levels of CIRP and IL-18 were determined using enzyme-linked immunosorbent assay. Results were compared among AOSD patients, RA patients, SLE patients and HCs. Results were also analyzed according to the clinical features of AOSD.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Serum CIRP levels were significantly higher in AOSD patients compared with RA patients (median: 9.6 ng\/mL, IQR [5.7\u201314.4] versus 3.2 ng\/mL, IQR [1.9\u20133.8]; <jats:italic>p<\/jats:italic> &lt; 0.001) and with HCs (2.8 ng\/mL, [IQR; 1.4\u20134.9], <jats:italic>p<\/jats:italic> &lt; 0.001). There was a significant positive correlation between serum CIRP levels and AOSD disease activity score (Pouchot\u2019s score <jats:italic>r<\/jats:italic> = 0.45, <jats:italic>p<\/jats:italic> = 0.003) as well as between AOSD-specific biomarkers ferritin and IL-18. However, there was no significant difference in the serum CIRP levels among AOSD patients with three different disease phenotypes.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>These results suggest that CIRP may play a significant role in the pathophysiology of AOSD and could be a potential biomarker for monitoring the disease activity of AOSD.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0255493","type":"journal-article","created":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T18:02:38Z","timestamp":1628186558000},"page":"e0255493","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["Clinical relevance for circulating cold-inducible RNA-binding protein (CIRP) in patients with adult-onset Still\u2019s disease"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3936-3007","authenticated-orcid":true,"given":"Yuya","family":"Fujita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Yago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Asano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruki","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Matsuoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jumpei","family":"Temmoku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuzo","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makiko","family":"Yashiro-Furuya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Kawakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Migita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,8,5]]},"reference":[{"issue":"1\u20132","key":"pone.0255493.ref001","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0378-1119(97)00530-1","article-title":"Cloning 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RNA-binding protein (CIRP) triggers inflammatory responses in hemorrhagic shock and sepsis","volume":"19","author":"X Qiang","year":"2013","journal-title":"Nat Med"},{"issue":"4","key":"pone.0255493.ref005","doi-asserted-by":"crossref","first-page":"FSO246","DOI":"10.4155\/fsoa-2017-0077","article-title":"Recent progress in the research of cold-inducible RNA-binding protein","volume":"3","author":"P Zhong","year":"2017","journal-title":"Future Sci OA"},{"issue":"1","key":"pone.0255493.ref006","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/cmi.2016.43","article-title":"Cold-inducible RNA-binding protein activates splenic T cells during sepsis in a TLR4-dependent manner","volume":"15","author":"AC Bolognese","year":"2018","journal-title":"Cell Mol Immunol"},{"issue":"20","key":"pone.0255493.ref007","doi-asserted-by":"crossref","first-page":"4130","DOI":"10.1016\/j.yexcr.2007.09.017","article-title":"The cold-inducible RNA-binding protein migrates from the nucleus to 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