{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:20:33Z","timestamp":1763018433089,"version":"3.40.5"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T00:00:00Z","timestamp":1629417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018867","name":"Heinz Nixdorf Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100018867","id-type":"DOI","asserted-by":"crossref"}]},{"name":"German Ministry of Education and Science","award":["01GS0820"],"award-info":[{"award-number":["01GS0820"]}]},{"name":"German Research Council","award":["projects SI 236\/8-1, SI 236\/9-1"],"award-info":[{"award-number":["projects SI 236\/8-1, SI 236\/9-1"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"\nObjectives<\/jats:title>\nN-Terminal pro Brain Natriuretic Peptide (NT-proBNP) is a diagnostic marker for heart failure and a prognostic factor for cardiovascular disease (CVD). The aim of this study was to examine the association of socioeconomic position (SEP) with NT-proBNP while assessing sex-differences and the impact of CVD risk factors and prevalent CVD on the association.<\/jats:p>\n<\/jats:sec>\n\nMethods<\/jats:title>\nBaseline data of 4598 participants aged 45\u201375 years of the Heinz Nixdorf Recall Study were used. Income and education were used as SEP indicators. Age- and sex-adjusted linear regression models were fitted to calculate effect size estimates and 95% confidence intervals (95%-CIs) for the total effect of SEP indicators on NT-proBNP, while potential mediation was assessed by additionally accounting for traditional CVD risk factors (i.e., systolic blood pressure, HDL cholesterol, LDL cholesterol, diabetes, anti-hypertensive medication, lipid-lowering medication, BMI, current smoking). Education and income were included separately in the models.<\/jats:p>\n<\/jats:sec>\n\nResults<\/jats:title>\nWith an age- and sex-adjusted average change in NT-proBNP of -6.47% (95%-CI: -9.91; -2.91) per 1000\u20ac, the association between income and NT-proBNP was more pronounced compared to using education as a SEP indicator (-0.80% [95%-CI: -1.92; 0.32] per year of education). Sex-stratified results indicated stronger associations in men (-8.43% [95%-CI: -13.21; -3.38] per 1000\u20ac; -1.63% [95%-CI: -3.23; -0.001] per year of education) compared to women (-5.10% [95%-CI: -9.82; -0.01] per 1000\u20ac; -1.04% [95%-CI: -2.59; 0.50] per year of education). After adjusting for CVD risk factors some of the observed effect size estimates were attenuated, while the overall association between SEP indicators and NT-proBNP was still indicated. The exclusion of participants with prevalent coronary heart disease or stroke did not lead to a substantial change in the observed associations.<\/jats:p>\n<\/jats:sec>\n\nConclusions<\/jats:title>\nIn the present study associations of education and income with NT-proBNP were observed in a population-based study sample. Only parts of the association were explained by traditional CVD risk factors, while there were substantial sex-differences in the strength of the observed association. Overt coronary heart disease or stroke did not seem to trigger the associations.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0255786","type":"journal-article","created":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T17:54:51Z","timestamp":1629482091000},"page":"e0255786","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Socioeconomic position is associated with N-terminal pro-brain natriuretic peptide (NT-proBNP)\u2014Results of the population-based Heinz Nixdorf Recall 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