{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:14:26Z","timestamp":1747196066790,"version":"3.40.5"},"reference-count":17,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T00:00:00Z","timestamp":1628467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>In anaesthetic practice the risk of hypoxia and arterial blood gas disturbances is evident, as most anaesthetic regimens depress the respiratory function. Hypoxia may be extended during recovery, and for this reason we wished to investigate if oxygen supply during a one hour post-operative period reduced the development of hypoxia and respiratory acidosis in rats anaesthetized with fentanyl\/fluanisone and midazolam. Twelve Sprague Dawley rats underwent surgery and were divided in two groups, breathing either 100% oxygen or atmospheric air during a post-operative period. The peripheral blood oxygen saturation and arterial acid-base status were analyzed for differences between the two groups. We found that oxygen supply after surgery prevented hypoxia but did not result in a significant difference in the blood acid-base status. All rats developed respiratory acidosis, which could not be reversed by supplemental oxygen supply. We concluded that oxygen supply improved oxygen saturation and avoided hypoxia but did not have an influence on the acid-base status.<\/jats:p>","DOI":"10.1371\/journal.pone.0255829","type":"journal-article","created":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T17:25:51Z","timestamp":1628529951000},"page":"e0255829","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["The effects of post-operative oxygen supply on blood oxygenation and acid-base status in rats anaesthetized with fentanyl\/fluanisone and midazolam"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8101-2630","authenticated-orcid":true,"given":"Leander","family":"Gaarde","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanie","family":"Kolstrup","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3796-1609","authenticated-orcid":true,"given":"Peter","family":"Bollen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2021,8,9]]},"reference":[{"issue":"12","key":"pone.0255829.ref001","doi-asserted-by":"crossref","first-page":"e0226430","DOI":"10.1371\/journal.pone.0226430","article-title":"Oxygen inhalation improves postoperative survival in ketamine-xylazine anaesthetised rats: An observational study","volume":"14","author":"M Mechelinck","year":"2019","journal-title":"PLoS ONE"},{"key":"pone.0255829.ref002","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/0041-008X(91)90088-V","article-title":"Xylazine-Induced Pulmonary Edema in Rats","volume":"108","author":"HR Amouzadeh","year":"1991","journal-title":"Toxicology and Applied Pharmacology"},{"issue":"1","key":"pone.0255829.ref003","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.resp.2007.05.008","article-title":"Time course of hypoxia-induced lung injury in rats","volume":"159","author":"B Rassler","year":"2007","journal-title":"Respir Physiol Neurobiol"},{"key":"pone.0255829.ref004","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1258\/002367700780384762","article-title":"Sufentanil and medetomidine anaesthesia in the rat and its reversal with atipamezole and butorphanol","volume":"34","author":"P Hedenqvist","year":"2000","journal-title":"Laboratory Animals"},{"issue":"1","key":"pone.0255829.ref005","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/2191-219X-2-44","article-title":"Anaesthesia and physiological monitoring during in vivo imaging of laboratory rodents: considerations on experimental outcomes and animal welfare","volume":"2","author":"JL Tremoleda","year":"2012","journal-title":"EJNMMI Res"},{"issue":"1","key":"pone.0255829.ref006","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.vascn.2014.03.003","article-title":"Monitoring the stress-level of rats with different types of anesthesia: a tail-artery cannulation protocol","volume":"70","author":"DZ Balla","year":"2014","journal-title":"J Pharmacol Toxicol Methods"},{"issue":"4","key":"pone.0255829.ref007","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.jvir.2019.07.027","article-title":"Transtail Artery Access in Rats: A New Technique for Repeatable Selective Angiography","volume":"31","author":"K Kumagai","year":"2020","journal-title":"J Vasc Interv Radiol"},{"edition":"5","year":"2015","author":"KA Grimm","key":"pone.0255829.ref008"},{"issue":"1","key":"pone.0255829.ref009","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1538\/expanim.15-0039","article-title":"Physiological, pharmacokinetic and liver metabolism comparisons between 3-, 6-, 12- and 18-month-old male Sprague Dawley rats under ketamine-xylazine anesthesia","volume":"65","author":"MC Giroux","year":"2016","journal-title":"Exp Anim"},{"issue":"4","key":"pone.0255829.ref010","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1590\/S0102-09352012000400011","article-title":"Hemodynamic and thermoregulatory effects of xylazine-ketamine mixture persist even after the anesthetic stage in rats","volume":"64","author":"C Picollo","year":"2012","journal-title":"Arq Bras Med Vet Zootec"},{"issue":"2","key":"pone.0255829.ref011","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1258\/002367784780891406","article-title":"Mitchell. 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