{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:49:54Z","timestamp":1792788594263,"version":"4.5.0"},"reference-count":11,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T00:00:00Z","timestamp":1630540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Tasso, Inc"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Efforts to minimize COVID-19 exposure during the current SARS-CoV-2 pandemic have led to limitations in access to medical care and testing. The Tasso-SST kit includes all of the components necessary for remote, capillary blood self-collection. In this study, we sought to investigate the accuracy and reliability of the Tasso-SST device as a self-collection device for measurement of SARS-CoV-2 IgG antibodies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Capillary blood was obtained via unsupervised and supervised application of the Tasso-SST device, and venous blood was collected by standard venipuncture. Unsupervised self-collected blood samples underwent either extreme summer or winter-simulated shipping conditions prior to testing. Sera obtained by all three methods were tested concurrently using the EuroImmun anti-SARS-CoV-2 S1 IgG assay in a CLIA-certified clinical laboratory.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Successful Tasso-SST capillary blood collection by unsupervised and supervised administration was completed by 93.4% and 94.5% of participants, respectively. Sera from 56 participants, 55 with documented (PCR+) COVID-19, and 33 healthy controls were then tested for anti-SARS-CoV-2 IgG antibodies. Compared to venous blood results, Tasso-SST-collected (unstressed) and the summer- and winter-stressed blood samples demonstrated Deming regression slopes of 1.00 (95% CI: 0.99\u20131.02), 1.00 (95% CI: 0.98\u20131.01), and 0.99 (95% CI: 0.97\u20131.01), respectively, with an overall accuracy of 98.9%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Capillary blood self-collection using the Tasso-SST device had a high success rate. Moreover, excellent concordance was found for anti-SARS-CoV-2 IgG results between Tasso-SST capillary and standard venous blood-derived sera. The Tasso-SST device should enable widespread collection of capillary blood for testing without medical supervision, facilitating epidemiologic studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0255841","type":"journal-article","created":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T14:04:58Z","timestamp":1630591498000},"page":"e0255841","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":71,"title":["Self-collection of capillary blood using Tasso-SST devices for Anti-SARS-CoV-2 IgG antibody testing"],"prefix":"10.1371","volume":"16","author":[{"given":"Tess","family":"Hendelman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anu","family":"Chaudhary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela C.","family":"LeClair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"van Leuven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Chee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L.","family":"Fink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily J.","family":"Welch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwin","family":"Berthier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brook A.","family":"Quist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Wald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark H.","family":"Wener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew N.","family":"Hoofnagle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5330-9464","authenticated-orcid":true,"given":"Chihiro","family":"Morishima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,9,2]]},"reference":[{"key":"pone.0255841.ref001","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.15585\/mmwr.mm6936a4","article-title":"Delay or avoidance of medical care because of COVID-19\u2013related concerns\u2014United States, June 2020","volume":"69","author":"M\u00c9 Czeisler","year":"2020","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"9","key":"pone.0255841.ref002","doi-asserted-by":"crossref","first-page":"679","DOI":"10.4155\/bio-2021-0027","article-title":"Assessment of low volume sampling technologies: utility in nonclinical and clinical studies","volume":"13","author":"KJ Williams","year":"2021","journal-title":"Bioanalysis"},{"issue":"3","key":"pone.0255841.ref003","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1207\/s15327906mbr2603_7","article-title":"How Many Subjects Does It Take To Do A Regression Analysis","volume":"26","author":"SB Green","year":"1991","journal-title":"Multivariate Behavioral Research"},{"key":"pone.0255841.ref004","unstructured":"EuroImmun. https:\/\/www.coronavirus-diagnostics.com\/documents\/Indications\/Infections\/Coronavirus\/EI_2606_D_UK_A.pdf (Accessed November 2020)."},{"key":"pone.0255841.ref005","volume-title":"R: A language and environment for statistical computing","author":"R Core Team","year":"2018"},{"issue":"8","key":"pone.0255841.ref006","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1158\/1055-9965.EPI-17-0170","article-title":"Preanalytical Stability of Antibodies to Pathogenic Antigens","volume":"26","author":"VS Hodgkinson","year":"2017","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"pone.0255841.ref007","doi-asserted-by":"crossref","first-page":"e0237833","DOI":"10.1371\/journal.pone.0237833","article-title":"High seroprevalence for SARS-CoV-2 among household members of essential workers detected using a dried blood spot assay","volume":"15","author":"TW McDade","year":"2020","journal-title":"PLOS ONE"},{"key":"pone.0255841.ref008","doi-asserted-by":"crossref","first-page":"e46","DOI":"10.1097\/INF.0000000000002955","article-title":"Dried blood spot as an alternative to plasma\/serum for SARS-CoV-2 IgG detection, an opportunity to be sized to facilitate COVID-19 surveillance among schoolchildren","volume":"40","author":"A Amendola","year":"2021","journal-title":"Pediatr Infect Dis J"},{"key":"pone.0255841.ref009","first-page":"20188","article-title":"A serological assay to detect SARS-CoV-2 antibodies in at-home collected finger-prick dried blood spots","volume":"10","author":"DG Karp","journal-title":"Sci Rep 2020"},{"key":"pone.0255841.ref010","unstructured":"Perkin Elmer. https:\/\/perkinelmer-appliedgenomics.com\/home\/sars-cov-2-testing-solutions\/perkinelmer-gsp-delfia-anti-sars-cov-2-igg-kit\/ (Accessed November 2020)."},{"key":"pone.0255841.ref011","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.15585\/mmwr.mm6943a3","article-title":"Trends in the Use of Telehealth During the Emergence of the COVID-19 Pandemic\u2014United States, January\u2013March 2020","volume":"69","author":"LM Koonin","year":"2020","journal-title":"MMWR Morb Mortal Wkly Rep"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0255841","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T14:05:21Z","timestamp":1630591521000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0255841"}},"subtitle":[],"editor":[{"given":"Mark Simonds","family":"Riddle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,9,2]]},"references-count":11,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2021,9,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0255841","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,2]]}}}