{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T16:51:58Z","timestamp":1793119918972,"version":"4.5.0"},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T00:00:00Z","timestamp":1628553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"national institute of health (nih), national institute of dental and craniofacial research","award":["R01DE024450"],"award-info":[{"award-number":["R01DE024450"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>The objective of this study was to use high-resolution cone-beam computed images (hr- CBCT) to diagnose degenerative joint disease in asymptomatic and symptomatic subjects using the Diagnostic Criteria for Temporomandibular Disorders DC\/TMD imaging criteria. This observational study comprised of 92 subjects age-sex matched and divided into two groups: clinical degenerative joint disease (c-DJD, n = 46) and asymptomatic control group (n = 46). Clinical assessment of the DJD and high-resolution CBCT images (isotropic voxel size of 0.08mm) of the temporomandibular joints were performed for each participant. An American Board of Oral and Maxillofacial Radiology certified radiologist and a maxillofacial radiologist used the DC\/TMD imaging criteria to evaluate the radiographic findings, followed by a consensus of the radiographic evaluation. The two radiologists presented a high agreement (Cohen\u2019s Kappa ranging from 0.80 to 0.87) for all radiographic findings (osteophyte, erosion, cysts, flattening, and sclerosis). Five patients from the c- DJD group did not present radiographic findings, being then classified as arthralgia. In the asymptomatic control group, 82.6% of the patients presented radiographic findings determinant of DJD and were then classified as osteoarthrosis or overdiagnosis. In conclusion, our results showed a high number of radiographic findings in the asymptomatic control group, and for this reason, we suggest that there is a need for additional imaging criteria to classify DJD properly in hr-CBCT images.<\/jats:p>","DOI":"10.1371\/journal.pone.0255937","type":"journal-article","created":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T17:25:01Z","timestamp":1628616301000},"page":"e0255937","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":26,"title":["Radiographic interpretation using high-resolution Cbct to diagnose degenerative temporomandibular joint disease"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3749-0918","authenticated-orcid":true,"given":"Jonas","family":"Bianchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Roberto Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f4nio","family":"Carlos de Oliveira Ruellas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00falia","family":"Vieira Pastana Bianchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence M.","family":"Ashman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilia","family":"Yatabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Benavides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana Naomi","family":"Soki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9786-2253","authenticated-orcid":true,"given":"Lucia Helena Soares","family":"Cevidanes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,8,10]]},"reference":[{"key":"pone.0255937.ref001","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1016\/j.joca.2015.05.028","article-title":"Machine learning classification of OARSI-scored human articular cartilage using magnetic resonance imaging","volume":"23","author":"BGG Ashinsky","year":"2015","journal-title":"Osteoarthr Cartil"},{"key":"pone.0255937.ref002","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s10439-019-02227-y","article-title":"Bone Density and Texture from Minimally Post-Processed Knee Radiographs in Subjects with Knee Osteoarthritis","volume":"47","author":"J Hirvasniemi","year":"2019","journal-title":"Ann Biomed Eng"},{"key":"pone.0255937.ref003","doi-asserted-by":"crossref","first-page":"20140235","DOI":"10.1259\/dmfr.20140235","article-title":"Temporomandibular joint diagnostics using CBCT","volume":"44","author":"TA Larheim","year":"2015","journal-title":"Dentomaxillofacial Radiol"},{"key":"pone.0255937.ref004","first-page":"1","article-title":"The detection accuracy of cone beam CT for osseous defects of the temporomandibular joint: A systematic review and meta-analysis","volume":"6","author":"RH Ma","year":"2016","journal-title":"Sci Rep"},{"key":"pone.0255937.ref005","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/joor.12240","article-title":"Assessment of osseous morphology of temporomandibular joint in asymptomatic participants with chewing-side preference","volume":"42","author":"H Jiang","year":"2015","journal-title":"J Oral Rehabil"},{"key":"pone.0255937.ref006","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.tripleo.2009.02.023","article-title":"Research diagnostic criteria for temporomandibular disorders (RDC\/TMD): development of image analysis criteria and examiner reliability for image analysis","volume":"107","author":"M Ahmad","year":"2009","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"pone.0255937.ref007","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12920-015-0108-y","article-title":"From big data analysis to personalized medicine for all: Challenges and opportunities","volume":"8","author":"A Alyass","year":"2015","journal-title":"BMC Med Genomics"},{"key":"pone.0255937.ref008","doi-asserted-by":"crossref","first-page":"4006","DOI":"10.1038\/ncomms5006","article-title":"Decoding tumour phenotype by noninvasive imaging using a quantitative radiomics approach","volume":"5","author":"HJWL Aerts","year":"2014","journal-title":"Nat Commun"},{"key":"pone.0255937.ref009","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1177\/0022034519865187","article-title":"Minimally Invasive Approach for Diagnosing TMJ Osteoarthritis","volume":"98","author":"B Shoukri","year":"2019","journal-title":"J Dent Res"},{"key":"pone.0255937.ref010","doi-asserted-by":"crossref","first-page":"20140282","DOI":"10.1259\/dmfr.20140282","article-title":"CBCT in orthodontics: assessment of treatment outcomes and indications for its use","volume":"44","author":"SD Kapila","year":"2014","journal-title":"Dentomaxillofac Radiol"},{"key":"pone.0255937.ref011","first-page":"44","article-title":"Spatial resolution in CBCT machines for dental\/maxillofacial applications\u2014What do we know today?","author":"D Br\u00fcllmann","year":"2015","journal-title":"Dentomaxillofacial Radiol"},{"key":"pone.0255937.ref012","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.ijom.2009.02.028","article-title":"Cone-beam computerized tomography (CBCT) imaging of the oral and maxillofacial region: a systematic review of the literature","volume":"38","author":"W De Vos","year":"2009","journal-title":"Int J Oral Maxillofac Surg"},{"key":"pone.0255937.ref013","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/S0022-3913(97)70145-8","article-title":"Management of temporomandibular disorders: Concepts and controversies","volume":"77","author":"C McNeill","year":"1997","journal-title":"J Prosthet Dent"},{"key":"pone.0255937.ref014","doi-asserted-by":"crossref","first-page":"6","DOI":"10.11607\/jop.1151","article-title":"Diagnostic Criteria for Temporomandibular Disorders (DC\/TMD) for Clinical and Research Applications: recommendations of the International RDC\/TMD Consortium Network* and Orofacial Pain Special Interest Group\u2020","volume":"28","author":"E Schiffman","year":"2014","journal-title":"J oral facial pain headache"},{"key":"pone.0255937.ref015","unstructured":"Morita CBCT Imaging. 2017. https:\/\/www.morita.com\/america\/en\/products\/diagnostic-and-imaging-equipment\/cone-beam-ct-systems\/3d-accuitomo-170\/?tab=technical_details."},{"key":"pone.0255937.ref016","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.jclinepi.2007.11.008","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"61","author":"E von Elm","year":"2008","journal-title":"J Clin Epidemiol"},{"key":"pone.0255937.ref017","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.tripleo.2005.05.055","article-title":"ALARA still applies","volume":"100","author":"Editorial","year":"2005","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"pone.0255937.ref018","doi-asserted-by":"crossref","first-page":"263","DOI":"10.5624\/isd.2015.45.4.263","article-title":"Cone-beam computed tomography: Time to move from ALARA to ALADA","volume":"45","author":"PP Jaju","year":"2015","journal-title":"Imaging Sci Dent"},{"key":"pone.0255937.ref019","doi-asserted-by":"crossref","first-page":"1343.e1","DOI":"10.1016\/j.joms.2016.01.029","article-title":"Condylar Erosion in Patients With Chronic Temporomandibular Joint Arthralgia: A Cone-Beam Computed Tomography Study","volume":"74","author":"R Emshoff","year":"2016","journal-title":"J Oral Maxillofac Surg"},{"key":"pone.0255937.ref020","first-page":"142","article-title":"Comparison of the Bony Changes of TMJ in Patients With and Without TMD Complaints Using CBCT","volume":"19","author":"S Shahidi","year":"2018","journal-title":"J Dent (Shiraz, Iran)"},{"key":"pone.0255937.ref021","doi-asserted-by":"crossref","first-page":"331","DOI":"10.11607\/ofph.1255","article-title":"Bony Deviations Revealed by Cone Beam Computed Tomography of the Temporomandibular Joint in Subjects Without Ongoing Pain","volume":"28","author":"M Bakke","year":"2018","journal-title":"J Oral Facial Pain Headache"},{"key":"pone.0255937.ref022","first-page":"665","article-title":"Bone remodelling in osteoarthritis","volume":"8","author":"DB Burr","year":"2012","journal-title":"Nat Publ Gr"},{"key":"pone.0255937.ref023","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.joca.2005.07.014","article-title":"Osteoarthritis cartilage histopathology: Grading and staging","volume":"14","author":"KPH Pritzker","year":"2006","journal-title":"Osteoarthr Cartil"},{"key":"pone.0255937.ref024","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/j.ijom.2015.06.023","article-title":"Temporomandibular joint osteoarthritis: Cone beam computed tomography findings, clinical features, and correlations","volume":"44","author":"S C\u00f6mert Kili\u00e7","year":"2015","journal-title":"Int J Oral Maxillofac Surg"},{"key":"pone.0255937.ref025","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1259\/dmfr\/16932758","article-title":"Role of different imaging modalities in assessment of temporomandibular joint erosions and osteophytes: A systematic review","volume":"37","author":"AM Hussain","year":"2008","journal-title":"Dentomaxillofacial Radiol"},{"key":"pone.0255937.ref026","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1259\/dmfr\/59263880","article-title":"Evaluation of the severity of temporomandibular joint osteoarthritic changes related to age using cone beam computed tomography","volume":"38","author":"KE Alexiou","year":"2009","journal-title":"Dentomaxillofacial Radiol"},{"key":"pone.0255937.ref027","first-page":"279","article-title":"Effect of Voxel Size and Object Location in the Field of View on Detection of Bone Defects in Cone Beam Computed Tomography","volume":"13","author":"HB Fakhar","year":"2016","journal-title":"J Dent (Tehran)"},{"key":"pone.0255937.ref028","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.tripleo.2010.01.008","article-title":"Quantification of condylar resorption in temporomandibular joint osteoarthritis","volume":"110","author":"LHS Cevidanes","year":"2010","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"pone.0255937.ref029","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.ijom.2012.03.006","article-title":"The prevalence of TMJ osteoarthritis in asymptomatic patients with dentofacial deformities: A cone-beam CT study","volume":"41","author":"Z Krisjane","year":"2012","journal-title":"Int J Oral Maxillofac Surg"},{"key":"pone.0255937.ref030","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1259\/dmfr\/17815139","article-title":"Evaluation of bone changes in the temporomandibular joint using cone beam CT","volume":"41","author":"ML dos Anjos Pontual","year":"2012","journal-title":"Dentomaxillofac Radiol"},{"key":"pone.0255937.ref031","doi-asserted-by":"crossref","DOI":"10.1259\/dmfr.20130082","article-title":"Small field of view cone beam CT temporomandibular joint imaging dosimetry","volume":"42","author":"TD Lukat","year":"2013","journal-title":"Dentomaxillofacial Radiol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0255937","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T17:25:47Z","timestamp":1628616347000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0255937"}},"subtitle":[],"editor":[{"given":"Farhan","family":"Bazargani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,8,10]]},"references-count":31,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2021,8,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0255937","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,10]]}}}