{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T17:53:29Z","timestamp":1773078809623,"version":"3.50.1"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T00:00:00Z","timestamp":1633910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003645","name":"Korean National Cancer Center","doi-asserted-by":"crossref","award":["NCC1810242-1"],"award-info":[{"award-number":["NCC1810242-1"]}],"id":[{"id":"10.13039\/501100003645","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Upper urinary tract urothelial carcinomas are relatively rare and have a cancer-specific survival rate of 20%\u201330%. The current gold standard treatment for nonmetastatic high-grade urinary tract urothelial carcinoma is radical nephroureterectomy with bladder cuff resection.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Objective<\/jats:title>\n<jats:p>This study aimed to compare conditional cancer-specific survival between open radical nephroureterectomy and laparoscopic radical nephroureterectomy in patients with nonmetastatic stage pT3-4 or TxN(+) locally advanced urinary tract urothelial carcinoma from five tertiary centers.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Methods<\/jats:title>\n<jats:p>The medical records of 723 patients were retrospectively reviewed. The patients had locally advanced and nodal staged tumors and had undergone open radical nephroureterectomy (n = 388) or laparoscopic radical nephroureterectomy (n = 260) at five tertiary Korean institutions from January 2000 and December 2012. To control for heterogenic baseline differences between the two modalities, propensity score matching and subgroup analysis were conducted. Conditional survival analysis was also conducted to determine survival outcome and to overcome differences in follow-up duration between the groups.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Results<\/jats:title>\n<jats:p>During the median 50.8-month follow up, 255 deaths occurred. In univariate analysis, significant factors affecting cancer-specific survival (e.g., age, history of bladder cancer, American Society of Anesthesiologists score, pathological N stage, and presence of lymphovascular invasion and carcinoma in situ) differed in each subsequent year. The cancer-specific survival between patients treated with open radical nephroureterectomy and laparoscopic radical nephroureterectomy was not different between patients with and without a history of bladder cancer. After adjusting baseline differences between the two groups by using propensity score matching, both groups still had no significant differences in cancer-specific survival.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec005\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>The two surgical modalities showed no significant differences in the 5-year cancer-specific survival in patients with locally advanced urinary tract urothelial carcinoma.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0255965","type":"journal-article","created":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T18:55:08Z","timestamp":1633978508000},"page":"e0255965","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["A retrospective multicenter comparison of conditional cancer-specific survival between laparoscopic and open radical nephroureterectomy in locally advanced upper tract urothelial carcinoma"],"prefix":"10.1371","volume":"16","author":[{"given":"Sung Han","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mi Kyung","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ja Hyeon","family":"Ku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seok Ho","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byong Chang","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bumsik","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ho Kyung","family":"Seo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2021,10,11]]},"reference":[{"key":"pone.0255965.ref001","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.eururo.2017.07.036","article-title":"European Association of Urology guidelines on upper urinary tract urothelial carcinoma: 2017 update","volume":"73","author":"M Roupr\u00eat","year":"2018","journal-title":"Eur Urol"},{"key":"pone.0255965.ref002","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.eururo.2014.08.003","article-title":"Conditional survival after radical nephroureterectomy for upper tract carcinoma","volume":"67","author":"G Ploussard","year":"2015","journal-title":"Eur Urol"},{"key":"pone.0255965.ref003","doi-asserted-by":"crossref","first-page":"621","DOI":"10.4143\/crt.2015.220","article-title":"Conditional survival and associated prognostic factors in patients with upper tract urothelial carcinoma after radical nephroureterectomy: a retrospective study at a single institution","volume":"48","author":"M Kang","year":"2016","journal-title":"Cancer Res Treatment"},{"key":"pone.0255965.ref004","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1089\/lap.2017.0662","article-title":"Comparison of open versus laparoscopic versus hand-assisted laparoscopic nephroureterectomy: a systematic review and meta-analysis","volume":"28","author":"A Nouralizadeh","year":"2018","journal-title":"J Laparoendosc Adv Surg Tech A"},{"key":"pone.0255965.ref005","doi-asserted-by":"crossref","first-page":"e2063","DOI":"10.7717\/peerj.2063","article-title":"Long-term oncologic outcomes of laparoscopic nephroureterectomy versus open nephroureterectomy for upper tract urothelial carcinoma: a systematic review and meta-analysis","volume":"4","author":"S Zhang","year":"2016","journal-title":"PeerJ"},{"key":"pone.0255965.ref006","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1007\/s00345-015-1712-3","article-title":"Laparoscopic radical nephroureterectomy is associated with worse survival outcomes than open radical nephroureterectomy in patients with locally advanced upper tract urothelial carcinoma","volume":"34","author":"HS Kim","year":"2016","journal-title":"World J Urol"},{"key":"pone.0255965.ref007","doi-asserted-by":"crossref","first-page":"963","DOI":"10.4143\/crt.2018.465","article-title":"Laparoscopy versus Open Nephroureterectomy in Prognostic Outcome of Patients with Advanced Upper Tract Urothelial Cancer: A Retrospective, Multicenter","volume":"51","author":"SH Kim","year":"2019","journal-title":"Propensity-Score Matching Analysis. 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nephroureterectomy for upper urinary tract urothelial carcinoma","volume":"32","author":"G Pignot","year":"2014","journal-title":"Urol Oncol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0255965","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T18:55:49Z","timestamp":1633978549000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0255965"}},"subtitle":[],"editor":[{"given":"Isaac 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