{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T08:39:03Z","timestamp":1787301543903,"version":"build-2736575974"},"reference-count":27,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T00:00:00Z","timestamp":1628640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"\n Introduction<\/jats:title>\n Cranial cruciate ligament failure is one of the principal causes of canine lameness. Several surgical procedures were proposed to achieve joint stabilisation; among these, the Modified Maquet Procedure involves using a titanium foam wedge to achieve and maintain the tibial tuberosity advancement. The force-plate analysis provides to objectively assess normal and abnormal gait and the outcome of different surgical techniques. The study evaluates the outcome of limbs that underwent Modified Maquet Procedure using land-force plate analysis comparing the operated limb with its healthy contralateral one as a control.<\/jats:p>\n <\/jats:sec>\n \n Materials and methods<\/jats:title>\n \n Thirty-five dogs with unilateral cranial cruciate ligament rupture were evaluated. Outcome after surgery was assessed by orthopaedic and radiographic evaluations and force plate gait analysis performed before surgery, at 15, 30 and 90 days after surgery. For objective comparison of ground reaction forces, data of operated limb were compared to contralateral limb on each time control and Symmetry Index at 90 days was determined. Healing radiographic signs,\n minor<\/jats:italic>\n and\n major<\/jats:italic>\n complication were reported.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A significant improvement in ground reaction forces was reached in all the treated limbs between set time intervals. The median percentage increase in ground reaction forces was constant from 15 to 90 days, with a Symmetry Index >9 in 54.2% of patients suggesting a normal gait symmetry. A complete bone healing was noticed at 90 days follow-up radiographic assessment. We experienced three\n major<\/jats:italic>\n (8.5%) and one\n minor<\/jats:italic>\n (2.8%) complications.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n To the Authors\u2019 knowledge, this is the first study in the veterinary literature that assessed outcomes of dogs undergoing Modified Maquet Procedure for the treatment of cranial cruciate ligament rupture using force plate gait analysis and healthy contralateral limb as a control group. Our results confirm that Modified Maquet Procedure is an effective method to stabilise the stifle joint.<\/jats:p>\n <\/jats:sec>","DOI":"10.1371\/journal.pone.0256011","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T13:27:34Z","timestamp":1628688454000},"page":"e0256011","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["Outcome after Modified Maquet Procedure in dogs with unilateral cranial cruciate ligament rupture: Evaluation of recovery limb function by use of force plate gait analysis"],"prefix":"10.1371","volume":"16","author":[{"given":"Giovanni","family":"Della Valle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9753-5452","authenticated-orcid":true,"given":"Chiara","family":"Caterino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Aragosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4612-1759","authenticated-orcid":true,"given":"Fabiana","family":"Micieli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7310-0246","authenticated-orcid":true,"given":"Dario","family":"Costanza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Di Palma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Piscitelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2578-7420","authenticated-orcid":true,"given":"Gerardo","family":"Fatone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,8,11]]},"reference":[{"key":"pone.0256011.ref001","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1055\/s-0037-1617480","article-title":"The history of canine cruciate ligament surgery from 1952\u20132005.","volume":"23","author":"LC Vaughan","year":"2010","journal-title":"Vet Comp Orthop Traumatol."},{"issue":"4","key":"pone.0256011.ref002","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0195-5616(93)50082-7","article-title":"Tibial plateau levelling osteotomy for repair of cranial cruciate ligament rupture in the canine.","volume":"23","author":"B Slocum","year":"1993","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"pone.0256011.ref003","volume-title":"Advancement of the tibial tuberosity for the treatment of cranial cruciate deficient stifle","author":"PM Montavon","year":"2002"},{"issue":"3","key":"pone.0256011.ref004","doi-asserted-by":"crossref","first-page":"223","DOI":"10.3415\/VCOT-10-01-0012","article-title":"Preliminary experience of a modified Maquet technique for repair of cranial cruciate ligament rupture in dogs.","volume":"24","author":"S Etchepareborde","year":"2011","journal-title":"Vet Comp Orthop Traumatol"},{"key":"pone.0256011.ref005","volume-title":"Orthofoam MMP wedge for canine cruciate disease. User guide (version V1. 2).","author":"MG Ness","year":"2014"},{"issue":"4","key":"pone.0256011.ref006","doi-asserted-by":"crossref","first-page":"242","DOI":"10.5326\/JAAHA-MS-6304","article-title":"The Modified Maquet Procedure (MMP) in Dogs: Technical Development and Initial Clinical Experience","volume":"52","author":"MG Ness","year":"2016","journal-title":"J Am Anim Hosp Assoc"},{"issue":"4","key":"pone.0256011.ref007","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1160\/VCOT-07-01-0008","article-title":"Force plate gait analysis at the walk and trot in dogs with low-grade hindlimb lameness.","volume":"20","author":"K Voss","year":"2007","journal-title":"Vet Comp Orthop Traumatol"},{"issue":"7","key":"pone.0256011.ref008","doi-asserted-by":"crossref","first-page":"832","DOI":"10.2460\/ajvr.2000.61.832","article-title":"Comparison of the trotting gaits of Labrador Retrievers and Greyhounds","volume":"61","author":"JE Bertram","year":"2000","journal-title":"Am J Vet Res"},{"issue":"6","key":"pone.0256011.ref009","first-page":"701","article-title":"Force platform analysis in clinically healthy Rottweilers: comparison with Labrador Retrievers.","volume":"39","author":"SH Molsa","year":"2010","journal-title":"Vet Surg"},{"issue":"2","key":"pone.0256011.ref010","doi-asserted-by":"crossref","first-page":"232","DOI":"10.2460\/javma.2005.226.232","article-title":"Effect of surgical technique on limb function after surgery for rupture of the CCL in dogs","volume":"226","author":"MG Conzemius","year":"2005","journal-title":"J Am Vet Med Assoc"},{"issue":"3","key":"pone.0256011.ref011","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1055\/s-0037-1617368","article-title":"Force plate gait analysis to assess limb function after tibial tuberosity advancement in dogs with cranial cruciate ligament disease.","volume":"21","author":"K Voss","year":"2008","journal-title":"Vet Comp Orthop Traumatol"},{"issue":"3","key":"pone.0256011.ref012","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1055\/s-0040-1701502","article-title":"Outcome after Tibial Plateau Levelling Osteotomy and Modified Maquet Procedure in Dogs with Cranial Cruciate Ligament Rupture","volume":"33","author":"J Knebel","journal-title":"Vet Comp Orthop Traumatol"},{"issue":"4","key":"pone.0256011.ref013","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1055\/s-0039-1684050","article-title":"Comparison of Outcomes Associated with Tibial Plateau Levelling Osteotomy and a Modified Technique for Tibial Tuberosity Advancement for the Treatment of Cranial Cruciate Ligament Disease in Dogs: A Randomised Clinical Study","volume":"32","author":"V Livet","year":"2019","journal-title":"Vet Comp Orthop Traumatol"},{"issue":"5","key":"pone.0256011.ref014","doi-asserted-by":"crossref","first-page":"461","DOI":"10.2460\/ajvr.80.5.461","article-title":"Evaluation of recovery of limb function by use of force plate gait analysis after tibial plateau levelling osteotomy for management of dogs with unilateral cranial cruciate ligament rupture","volume":"80","author":"H Amimoto","year":"2019","journal-title":"Am J Vet Res"},{"issue":"8","key":"pone.0256011.ref015","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1111\/j.1532-950X.2010.00763.x","article-title":"Proposed Definitions and Criteria for Reporting Time Frame, Outcome, and Complications For Clinical Orthopedic Studies in Veterinary Medicine","volume":"39","author":"JL Cook","year":"2010","journal-title":"Vet Surg"},{"issue":"131","key":"pone.0256011.ref016","first-page":"339","article-title":"Controlled, blinded force platform analysis of the effect of intraarticular injection of autologous adipose-derived mesenchymal stem cells associated to PRGF-Endoret in osteoarthritic dogs","volume":"9","author":"JM Vilar","year":"2013","journal-title":"BMC Vet Res"},{"key":"pone.0256011.ref017","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1111\/j.1532-950X.2010.00729.x","article-title":"Relationships of body weight, body size, subject velocity, and vertical ground reaction forces in trotting dogs","author":"K Voss","year":"2010","journal-title":"Vet Surg"},{"issue":"6","key":"pone.0256011.ref018","first-page":"7","article-title":"Early diagnosis of canine hip dysplasia (CHD).","volume":"29","author":"A Vezzoni","year":"2015","journal-title":"Veterinaria (Cremona)"},{"key":"pone.0256011.ref019","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.tvjl.2018.07.003","article-title":"Review Regional anaesthetic techniques for the pelvic limb and abdominal wall in small animals: A review of the literature and technique description","volume":"238","author":"DA Portela","year":"2018","journal-title":"Vet J"},{"issue":"14","key":"pone.0256011.ref020","first-page":"3061","article-title":"Enhancement of Bone Ingrowth into a Porous Titanium Structure to Improve Osseointegration of Dental Implants","volume":"13","author":"JY Hong","year":"2020","journal-title":"A Pilot Study in the Canine Model. Materials."},{"issue":"1","key":"pone.0256011.ref021","article-title":"Role of Tibial Tuberosity Fracture\/Fissure through the Maquet Hole in Stifle Osteoarthritis after Porous Tibial Tuberosity Advancement in Dogs at Mid-Term Follow-Up","volume":"7","author":"AM Crovace","year":"2020","journal-title":"Vet Sci."},{"issue":"1","key":"pone.0256011.ref022","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/vsu.12707","article-title":"Risk factors for tibial damage associated with the modified Maquet technique in 174 stifles","volume":"47","author":"MD Lefebvre","year":"2018","journal-title":"Vet Surg"},{"issue":"5","key":"pone.0256011.ref023","doi-asserted-by":"crossref","first-page":"339","DOI":"10.3415\/VCOT-14-10-0153","article-title":"Complications and outcome of a new modified Maquet technique for treatment of cranial cruciate ligament rupture in 82 dogs.","volume":"28","author":"J Ramirez","year":"2015","journal-title":"Vet Comp Orthop Traumatol"},{"issue":"12","key":"pone.0256011.ref024","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.2460\/ajvr.2003.64.1479","article-title":"Effect of velocity on ground reaction forces in dogs with lameness attributable to tearing of the cranial cruciate ligament","volume":"64","author":"R Evans","year":"2003","journal-title":"Am J Vet Res"},{"issue":"2","key":"pone.0256011.ref025","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/vsu.12445","article-title":"Long Term Functional Outcome of Tibial Tuberosity Advancement vs Tibial Plateau Leveling Osteotomy and Extracapsular Repair in a Heterogeneous Population of Dogs","volume":"45","author":"U Krotscheck","year":"2016","journal-title":"Vet Surg"},{"key":"pone.0256011.ref026","first-page":"106","article-title":"Effect of dog breed and body conformation on vertical ground reaction forces, impulses, and stance times","author":"K Voss","year":"2011","journal-title":"Vet Comp Orthop Traumatol"},{"key":"pone.0256011.ref027","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3415\/VCOT-16-04-0054","article-title":"The evaluation of limb symmetry indices using ground reaction forces collected with one or two force plates in healthy dogs","volume":"30","author":"SG Volstad NJ","year":"2017","journal-title":"Vet Comp Orthop Traumatol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0256011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T13:28:00Z","timestamp":1628688480000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0256011"}},"subtitle":[],"editor":[{"given":"Silvia","family":"Sabattini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,8,11]]},"references-count":27,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2021,8,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0256011","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,11]]}}}