{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T19:58:03Z","timestamp":1768593483376,"version":"3.49.0"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T00:00:00Z","timestamp":1629676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"PharmaTox Strategic Research Initiative"},{"name":"Research Council of Norway, FRIMEDBIO","award":["288696"],"award-info":[{"award-number":["288696"]}]},{"name":"European Research Council Starting Grant \u201cDrugsInPregnancy\u201d","award":["639377"],"award-info":[{"award-number":["639377"]}]},{"name":"European Research Council Starting Grant \u201cDrugsInPregnancy\u201d","award":["639377"],"award-info":[{"award-number":["639377"]}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["1T32HL098048 NHLBI"],"award-info":[{"award-number":["1T32HL098048 NHLBI"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objective<\/jats:title>\n<jats:p>To characterize nationwide utilization patterns of migraine pharmacotherapy before, during, and after pregnancy in women with triptan use.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Population-based data were obtained by linking the Medical Birth Registry of Norway and the Norwegian Prescription Database from 2006 to 2017. We included 22,940 pregnancies among 19,669 women with at least one filled triptan prescription, a proxy for migraine, in the year before pregnancy or during pregnancy. The population was classified into four groups: i) continuers; ii) discontinuers; iii) initiators, and vi) post-partum re-initiators. Participant characteristics and prescription fills for other drugs such as analgesics, antinauseants, and preventive drugs among the groups were examined, along with an array of triptan utilization parameters.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>In total, 20.0% of the women were classified as triptan continuers, 54.1% as discontinuers, 8.0% as initiators, and 17.6% as re-initiators. Extended use of triptans (\u226515 daily drug doses\/month) occurred among 6.9% of the continuers in the first trimester. The top 10% of triptan continuers and initiators accounted for 41% (95% CI: 39.2% - 42.5%) and 33% (95% CI: 30.3% - 35.8%) of the triptan volume, respectively. Triptan continuers and initiators had similar patterns of acute co-medication during pregnancy, but use of preventive drugs was more common among the continuers before, during, and after pregnancy.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Among women using triptans before and during pregnancy, one in four continued triptan treatment during pregnancy, and extended triptan use was relatively low. Triptan discontinuation during and in the year after pregnancy was common. Use of other acute migraine treatments was higher among both continuers and initiators of triptans. Women using preventive migraine treatment were most commonly triptan continuers and re-initiators after pregnancy. Prescribing to and counseling of women with migraine should be tailored to the condition severity and their information needs to promote optimal migraine management in pregnancy.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0256214","type":"journal-article","created":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T17:43:14Z","timestamp":1629740594000},"page":"e0256214","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Perinatal use of triptans and other drugs for migraine\u2014A nationwide drug utilization study"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8167-9243","authenticated-orcid":true,"given":"Fatima","family":"Tauqeer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mollie","family":"Wood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2841-5868","authenticated-orcid":true,"given":"Sarah","family":"Hjorth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Lupattelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hedvig","family":"Nordeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2021,8,23]]},"reference":[{"issue":"10100","key":"pone.0256214.ref001","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/S0140-6736(17)32154-2","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990\u20132016: a systematic analysis for the Global Burden of Disease Study 2016","volume":"390","author":"T Vos","year":"2017","journal-title":"The Lancet"},{"issue":"5","key":"pone.0256214.ref002","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S1474-4422(18)30499-X","article-title":"Global, regional, and national burden of neurological disorders, 1990\u20132016: a systematic analysis for the Global Burden of Disease Study 2016.","volume":".18","author":"VL Feigin","year":"2019","journal-title":"The Lancet Neurology"},{"issue":"5","key":"pone.0256214.ref003","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.mayocp.2017.11.027","article-title":"Migraine Throughout the Female Reproductive Life Cycle","volume":"93","author":"SS Faubion","year":"2018","journal-title":"Mayo Clinic Proceedings"},{"issue":"1","key":"pone.0256214.ref004","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s10194-017-0816-0","article-title":"Headache and pregnancy: a systematic review.","volume":"18","author":"A Negro","year":"2017","journal-title":"J Headache Pain"},{"issue":"4","key":"pone.0256214.ref005","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1111\/head.12540","article-title":"Pregnancy and Lactation\u2013Migraine Management. 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