{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:18:02Z","timestamp":1791271082240,"version":"4.1.0"},"reference-count":69,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T00:00:00Z","timestamp":1629849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Institutional Strategy of the University of Tuebingen"},{"name":"European Social Fund and the Ministry of Science, Research and the Arts Baden-Wuerttemberg"},{"name":"LEAD Graduate School & Research Network"},{"name":"Tuebingen Postdoc Academy for Research on Education (PACE) at the Hector Research Institute of Education Sciences and Psychology, Tuebingen"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Arithmetic processing is represented in a fronto-parietal network of the brain. However, activation within this network undergoes a shift from domain-general cognitive processing in the frontal cortex towards domain-specific magnitude processing in the parietal cortex. This is at least what is known about development from findings in children and young adults. In this registered report, we set out to replicate the fronto-parietal activation shift for arithmetic processing and explore for the first time how neural development of arithmetic continues during aging. This study focuses on the behavioral and neural correlates of arithmetic and arithmetic complexity across the lifespan, i.e., childhood, where arithmetic is first learned, young adulthood, when arithmetic skills are already established, and old age, when there is lifelong arithmetic experience. Therefore, brain activation during mental arithmetic will be measured in children, young adults, and the elderly using functional near-infrared spectroscopy (fNIRS). Arithmetic complexity will be manipulated by the carry and borrow operations in two-digit addition and subtraction. The findings of this study will inform educational practice, since the carry and borrow operations are considered as obstacles in math achievement, and serve as a basis for developing interventions in the elderly, since arithmetic skills are important for an independent daily life.<\/jats:p>","DOI":"10.1371\/journal.pone.0256232","type":"journal-article","created":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T17:41:53Z","timestamp":1629913313000},"page":"e0256232","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Developmental fronto-parietal shift of brain activation during mental arithmetic across the lifespan: A registered report protocol"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5947-7960","authenticated-orcid":true,"given":"Christina","family":"Artemenko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,8,25]]},"reference":[{"key":"pone.0256232.ref001","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1016\/j.neuroimage.2010.10.009","article-title":"Is 2+2 = 4? 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Menon","year":"2010","journal-title":"ZDM Math Educ"},{"key":"pone.0256232.ref014","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1037\/0096-3445.132.4.566","article-title":"Executive Functioning as a Potential Mediator of Age-Related Cognitive Decline in Normal Adults","volume":"132","author":"TA Salthouse","year":"2003","journal-title":"J Exp Psychol Gen"},{"key":"pone.0256232.ref015","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1080\/13825580590925116","article-title":"Longitudinal Changes in Memory Performance and Processing Speed in Old Age abstract Keywords Longitudinal Changes in Memory Performance and Processing Speed in Old Age","volume":"12","author":"U Lemke","year":"2005","journal-title":"Aging, Neuropsychol Cogn"},{"key":"pone.0256232.ref016","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1037\/0882-7974.6.3.474","article-title":"Cognitive addition: strategy choice and speed-of-processing differences in young and elderly adults","volume":"6","author":"DC Geary","year":"1991","journal-title":"Psychol Aging"},{"key":"pone.0256232.ref017","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1076\/clin.17.3.331.18092","article-title":"Number Processing and Calculation\u2013Normative Data from Healthy Adults","volume":"17","author":"M Delazer","year":"2003","journal-title":"Clin Neuropsychol"},{"key":"pone.0256232.ref018","first-page":"397","volume-title":"Handbook of Mathematical Cognition","author":"S Duverne","year":"2005"},{"key":"pone.0256232.ref019","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1037\/pag0000431","article-title":"The Use of Automated Procedures by Older Adults With High Arithmetic Skills During Addition Problem Solving","volume":"35","author":"C Thevenot","year":"2019","journal-title":"Psychol Aging"},{"key":"pone.0256232.ref020","first-page":"106","volume-title":"Oxford Handbook of Mathematical Cognition","author":"H-C Nuerk","year":"2015"},{"key":"pone.0256232.ref021","first-page":"74","article-title":"The addition of two-digit numbers: exploring carry versus no-carry problems","volume":"47","author":"M. 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Wechsler","author":"F. Petermann","year":"2014","edition":"4"},{"key":"pone.0256232.ref052","article-title":"Cognitive enhancement or emotion regulation: The influence of brain stimulation on math anxiety","author":"M Soltanlou","year":"2018","journal-title":"Cortex"},{"key":"pone.0256232.ref053","volume-title":"Reynolds und Randy W. 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