{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T18:32:42Z","timestamp":1779129162992,"version":"3.51.4"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T00:00:00Z","timestamp":1629072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Delegation of Clinical Research and Innovation of University Hospital of Nice \u201c2014\u201d"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Bariatric surgery (BS) might be a nephroprotective treatment in obese patients with chronic kidney disease (CKD), and the non-linear relation between body surface area (BSA) and extracellular fluid volume (ECFV) in obese people raises the question of the most relevant way to scale glomerular filtration rate (GFR) for assessing renal function changes after BS.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>We screened 1774 BS candidates and analysed 10 consecutive participants with CKD stage 3. True GFR (mGFR), measured by the renal clearance of <jats:sup>51<\/jats:sup>Cr-ethylenediaminetetraacetic acid (EDTA), was scaled either to BSA (mGFR<jats:sub>BSA<\/jats:sub>) or to ECFV measured by <jats:sup>51<\/jats:sup>Cr-EDTA distribution volume (mGFR<jats:sub>ECFV<\/jats:sub>) before and one year after BS.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>The 10 candidates for BS had a mean body mass index of 43.3 \u00b1 3.6 kg\/m<jats:sup>2<\/jats:sup> and a mean GFR of 48 \u00b1 8 mL\/min\/1.73 m<jats:sup>2<\/jats:sup>. Six participants had a sleeve gastrectomy and four had a Roux-en-Y gastric bypass. One year after BS, ECFV decreased (23.2 \u00b1 6.2 to 17.9 \u00b1 4.3 L, p = 0.001), absolute mGFR was not significantly modified (74 \u00b1 23 versus 68 \u00b119 mL\/min), mGFR<jats:sub>BSA<\/jats:sub> did not change significantly (53 \u00b1 18 versus 56 \u00b1 17 mL\/min\/1.73 m<jats:sup>2<\/jats:sup>) whereas mGFR<jats:sub>ECFV<\/jats:sub> significantly increased (42 \u00b1 13 versus 50 \u00b1 14 mL\/min\/12.9 L, p = 0.037). The relation between mGFR<jats:sub>ECFV<\/jats:sub> and mGFR<jats:sub>BSA<\/jats:sub> was different from the identity line before (p = 0.014) but not after BS (p = 0.09).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>There is a difference between mGFR<jats:sub>BSA<\/jats:sub> and mGFR<jats:sub>ECFV<\/jats:sub> following BS and the latter might better reflect the adequacy between renal function and corpulence.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0256234","type":"journal-article","created":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T18:40:23Z","timestamp":1629139223000},"page":"e0256234","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Extracellular fluid volume: A suitable indexation variable to assess impact of bariatric surgery on glomerular filtration rate in patients with chronic kidney disease"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7326-8751","authenticated-orcid":true,"given":"Caroline","family":"Grangeon-Chapon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey","family":"Laurain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent L. 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