{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:48:56Z","timestamp":1792788536358,"version":"4.5.0"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T00:00:00Z","timestamp":1629331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"rajavithi research grant","award":["056\/2563"],"award-info":[{"award-number":["056\/2563"]}]},{"name":"rajavithi research grant","award":["056\/2563"],"award-info":[{"award-number":["056\/2563"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To compare the efficacy and safety profiles of XEN implant versus trabeculectomy as a surgical intervention for primary glaucoma<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study of mild to moderate stage glaucoma patients, who had undergone either XEN implantation or trabeculectomy with adjunctive mitomycin C, was performed in a tertiary eye center<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty-seven eyes for XEN implant and 57 eyes for trabeculectomy with medically uncontrolled glaucoma were included. Preoperative IOP was 16\u201333 mmHg. Visual field mean deviation was -9.11\u00b16.93 dB in XEN group, and -9.67\u00b15.06 dB in trabeculectomy group (p = 0.195). At the 24-month timepoint, mean IOP was reduced from 21.6\u00b14.0 to 14.6\u00b13.5 mmHg (32.4% reduction) in the XEN group (p&lt;0.001), and from 22.5\u00b15.8 to 12.5\u00b14.1 mmHg (44.4% reduction) in the trabeculectomy group (p&lt;0.001). Final IOP in XEN was significantly higher than trabeculectomy (p = 0.008) with lesser mean IOP percentage reduction at month 24 (p = 0.045). Mean number of medications was reduced from 2.2\u00b11.4 to 0.5\u00b10.7 in XEN group (p&lt;0.001), and from 2.4\u00b10.7 to 0.8\u00b11.3 in trabeculectomy group (p&lt;0.001). Final number of medications was not different between the groups (p = 0.225). Surgical success was comparable between XEN and trabeculectomy group. Overall success was 71.4% vs. 73.3% (p = 0.850), and complete success was 62.9% vs. 62.2% (p = 0.954), respectively. XEN had lower rate of numerical hypotony than trabeculectomy. No serious complication occurred in either procedure group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>At 24 months, XEN showed a rate of success comparable to that of trabeculectomy. Although XEN had a higher final IOP than trabeculectomy, XEN achieved 32% IOP reduction, and achieved final IOP in mid-teen level. No serious complication occurred in either group. XEN can be applied for treatment of mild to moderate stages of glaucoma in Southeast Asian patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0256362","type":"journal-article","created":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T15:02:06Z","timestamp":1629385326000},"page":"e0256362","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":36,"title":["24-month outcomes of XEN45 gel implant versus trabeculectomy in primary glaucoma"],"prefix":"10.1371","volume":"16","author":[{"given":"Boonsong","family":"Wanichwecharungruang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1824-4049","authenticated-orcid":true,"given":"Nitee","family":"Ratprasatporn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,8,19]]},"reference":[{"issue":"11","key":"pone.0256362.ref001","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","article-title":"Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis","volume":"121","author":"YC Tham","year":"2014","journal-title":"Ophthalmology"},{"issue":"3","key":"pone.0256362.ref002","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/IJG.0b013e31820719f6","article-title":"The glaucomatous process and the evolving definition of glaucoma","volume":"21","author":"MB Shields","year":"2012","journal-title":"J Glaucoma"},{"issue":"4","key":"pone.0256362.ref003","first-page":"673","article-title":"Trabeculectomy. 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