{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T08:35:11Z","timestamp":1777624511473,"version":"3.51.4"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T00:00:00Z","timestamp":1630022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009168","name":"Animal and Plant Health Inspection Service","doi-asserted-by":"publisher","award":["AP17VSSPRS00G002"],"award-info":[{"award-number":["AP17VSSPRS00G002"]}],"id":[{"id":"10.13039\/100009168","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>The purpose of this study was to evaluate the pharmacokinetics of tulathromycin in the plasma and maternal and fetal tissues of pregnant ewes when administered within 24 hours of a single, IV <jats:italic>Campylobacter jejuni<\/jats:italic> (<jats:italic>C<\/jats:italic>. <jats:italic>jejuni<\/jats:italic>) challenge. Twelve, pregnant ewes between 72\u201392 days of gestation were challenged IV with <jats:italic>C<\/jats:italic>. <jats:italic>jejuni<\/jats:italic> IA3902 and then treated with 1.1 ml\/45.36 kg of tulathromycin subcutaneously 18 hours post-challenge. Ewes were bled at predetermined time points and euthanized either at a predetermined time point or following the observation of vaginal bleeding or abortion. Following euthanasia, tissues were collected for bacterial culture, pharmacokinetics and histologic examination. The maximum (geometric) mean tulathromycin plasma concentration was estimated at 0.302 \u03bcg\/mL, with a peak level observed at around 1.2 hours. The apparent systemic clearance of tulathromycin was estimated at 16.6 L\/h (or 0.28 L\/kg\/h) with an elimination half-life estimated at approximately 22 hours. The mean tissue concentrations were highest in the uterus (2.464 \u03bcg\/g) and placentome (0.484 \u03bcg\/g), and were lowest in fetal liver (0.11 \u03bcg\/g) and fetal lung (0.03 \u03bcg\/g). Compared to previous reports, results of this study demonstrate that prior IV administration of <jats:italic>C<\/jats:italic>. <jats:italic>jejuni<\/jats:italic> appeared to substantially alter the pharmacokinetics of tulathromycin, reducing both the peak plasma concentrations and elimination half-life. However, additional controlled trials are required to confirm those observations.<\/jats:p>","DOI":"10.1371\/journal.pone.0256862","type":"journal-article","created":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T17:30:38Z","timestamp":1630085438000},"page":"e0256862","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Pharmacokinetics of tulathromycin in pregnant ewes (Ovis aries) challenged with Campylobacter jejuni"],"prefix":"10.1371","volume":"16","author":[{"given":"Michael","family":"Yaeger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0997-3111","authenticated-orcid":true,"given":"Jonathan 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