{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T02:38:07Z","timestamp":1788489487986,"version":"build-2803163510"},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T00:00:00Z","timestamp":1630627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"crossref","award":["2018IF0803"],"award-info":[{"award-number":["2018IF0803"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>The focus of studies on kidney transplantation (KT) has largely shifted from T-cell mediated rejection (TCMR) to antibody-mediated rejection (ABMR). However, there are still cases of pure acute TCMR in histological reports, even after a long time following transplant. We thus evaluated the impact of pure TCMR on graft survival (GS) according to treatment response. We also performed molecular diagnosis using a molecular microscope diagnostic system on a separate group of 23 patients. A total of 63 patients were divided into non-responders (N = 22) and responders (N = 44). Non-response to rejection treatment was significantly associated with the following factors: glomerular filtration rate (GFR) at biopsy, \u0394GFR, TCMR within one year, t score, and IF\/TA score. We also found that non-responder vs. responder (OR = 3.31;<jats:italic>P =<\/jats:italic>0.036) and lower GFR at biopsy (OR = 0.56;<jats:italic>P =<\/jats:italic>0.026) were independent risk factors of graft failure. The responders had a significantly superior overall GS rate compared with the non-responders (<jats:italic>P<\/jats:italic>= 0.004). Molecular assessment showed a good correlation with histologic diagnosis in ABMR, but not in TCMR. Solitary TCMR was a significant risk factor of graft failure in patients who did not respond to rejection treatment.<\/jats:p>","DOI":"10.1371\/journal.pone.0256898","type":"journal-article","created":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T17:28:57Z","timestamp":1630690137000},"page":"e0256898","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Pure T-cell mediated rejection following kidney transplant according to response to treatment"],"prefix":"10.1371","volume":"16","author":[{"given":"Hyunwook","family":"Kwon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Hoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngmin","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong 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