{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T17:11:54Z","timestamp":1772212314293,"version":"3.50.1"},"reference-count":21,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T00:00:00Z","timestamp":1631145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>\n                    This study evaluates the effect of local infiltration analgesia with bupivacaine and adrenaline on perioperative blood loss in total hip arthroplasty. Patients who had primary total hip arthroplasty were retrospectively assigned to two groups. One group had 100 ml of bupivacaine\/adrenaline solution injected into periarticular soft tissues at the end of the procedure. There were 55 patients in the infiltrated hip group and 44 patients in the not infiltrated group. Patients\u2019 hemoglobin level (Hb), hematocrit (HTC), red blood count (RBC), platelet count (PLT) and International Normalized Ratio (INR) as well as the need for blood transfusions were compared statistically between groups preoperatively and postoperatively. There were no significant differences between Hb, HTC or RBC levels as well as the rate and amount of blood transfusions on the 1\n                    <jats:sup>st<\/jats:sup>\n                    , 4\n                    <jats:sup>th<\/jats:sup>\n                    postoperative days or at patients\u2019 discharge between infiltrated and not infiltrated groups. This study does not support the hypothesis that the use of local infiltration analgesia with adrenaline may reduce perioperative blood loss in total hip arthroplasty.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0257202","type":"journal-article","created":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T14:05:03Z","timestamp":1631196303000},"page":"e0257202","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Local infiltration analgesia with bupivacaine and adrenaline does not reduce perioperative blood loss in total hip arthroplasty"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0850-6041","authenticated-orcid":true,"given":"Marcin","family":"Ceynowa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz","family":"Sikora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek","family":"Roc\u0142awski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariusz","family":"Treder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof","family":"Kolarz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafa\u0142","family":"Pankowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz","family":"Mazurek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2021,9,9]]},"reference":[{"key":"pone.0257202.ref001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13018-018-0948-1","article-title":"Zhang H jie. Comparative effectiveness and safety of tranexamic acid plus diluted epinephrine to control blood loss during total hip arthroplasty: A meta-analysis","volume":"13","author":"Z Wang","year":"2018","journal-title":"J Orthop Surg Res"},{"key":"pone.0257202.ref002","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1016\/S0140-6736(07)60457-7","article-title":"The operation of the century: total hip replacement","volume":"370","author":"ID Learmonth","year":"2007","journal-title":"Lancet"},{"key":"pone.0257202.ref003","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1007\/s00264-016-3133-3","article-title":"Effect of local anaesthetic wound infiltration on acute pain and bleeding after primary total hip arthroplasty: the EDIPO randomised controlled study","volume":"40","author":"G Villatte","year":"2016","journal-title":"Int Orthop"},{"key":"pone.0257202.ref004","first-page":"1","article-title":"The efficacy of intraoperative periarticular injection in Total hip arthroplasty: A systematic review and meta-analysis","volume":"20","author":"HH Ma","year":"2019","journal-title":"BMC Musculoskelet Disord"},{"key":"pone.0257202.ref005","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1007\/s00402-007-0470-0","article-title":"Cement-in-cement revision hip arthroplasty: An analysis of clinical and biomechanical literature","volume":"128","author":"P Keeling","year":"2008","journal-title":"Arch Orthop Trauma Surg"},{"key":"pone.0257202.ref006","doi-asserted-by":"crossref","first-page":"e0246740","DOI":"10.1371\/journal.pone.0246740","article-title":"The cement-bone bond is weaker than cement-cement bond in cement-in-cement revision arthroplasty. A comparative biomechanical study","volume":"16","author":"M Ceynowa","year":"2021","journal-title":"PLoS One"},{"key":"pone.0257202.ref007","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1007\/s00264-018-3788-z","article-title":"Peri-articular injection of an analgesic mixture in primary total hip arthroplasty: an effective strategy for pain control during the first post-operative day","volume":"42","author":"M Bautista","year":"2018","journal-title":"Int Orthop"},{"key":"pone.0257202.ref008","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1080\/17453670710014950","article-title":"Local infiltration analgesia: a technique for the control of acute postoperative pain following knee and hip surgery: a case study of 325 patients.","volume":"79","author":"DDR Kerr","year":"2008","journal-title":"Acta Orthop"},{"key":"pone.0257202.ref009","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1080\/17453670710013663","article-title":"Postoperative analgesia in total hip arthroplasty. A randomized double-blinded, placebo-controlled study on peropera- tive and postoperative ropivacaine, ketorolac, and adrenaline wound infiltration","volume":"78","author":"LJ Andersen","year":"2007","journal-title":"Acta Orthop"},{"key":"pone.0257202.ref010","first-page":"2034","article-title":"Reduced Blood Loss and Transfusion Rates: Additional Bene fi ts of Local In fi ltration Anaesthesia","volume":"30","author":"MA Bhutta","year":"2015","journal-title":"Knee Arthroplasty Patients. J Arthroplasty"},{"key":"pone.0257202.ref011","first-page":"325","article-title":"A comparison of the effects on postoperative bleeding of the intra-articular application of tranexamic acid and adrenalin in total knee arthroplasty","volume":"69","author":"F Durgut","year":"2019","journal-title":"J Pak Med Assoc"},{"key":"pone.0257202.ref012","article-title":"The efficacy of periarticular drug infiltration for postoperative pain after total hip arthroplasty: A systematic review and meta-analysis","volume":"96","author":"Y Wang","year":"2017","journal-title":"Med (United States)."},{"key":"pone.0257202.ref013","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1016\/j.arth.2015.06.005","article-title":"Topical Application of Tranexamic Acid Plus Diluted Epinephrine Reduces Postoperative Hidden Blood Loss in Total Hip Arthroplasty","volume":"30","author":"F Gao","year":"2015","journal-title":"J Arthroplasty"},{"key":"pone.0257202.ref014","first-page":"7","article-title":"Does epinephrine wash reduce blood loss in primary total hip replacements?","volume":"1","author":"A Yewlett","year":"2014","journal-title":"Wales Orthop J"},{"key":"pone.0257202.ref015","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1302\/0301-620X.64B1.7068713","article-title":"The direct lateral approach to the hip","volume":"64-B","author":"K. Hardinge","year":"1982","journal-title":"J Bone Jt Surg"},{"key":"pone.0257202.ref016","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1423-0410.2008.01071.x","article-title":"Validation of a haemoglobin dilution method for estimation of blood loss","volume":"95","author":"A Meunier","year":"2008","journal-title":"Vox Sang"},{"key":"pone.0257202.ref017","first-page":"83","article-title":"Predictors for blood transfusion following total knee arthroplasty: A prospective randomised study","volume":"74","author":"F Mesa-Ramos","year":"2008","journal-title":"Acta Orthop Belg"},{"key":"pone.0257202.ref018","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1055\/s-0030-1247737","article-title":"Reduced Blood Loss After Total Knee Arthroplasty with Local Injection of Bupivacaine and Epinephrine","volume":"22","author":"LA Anderson","year":"2009","journal-title":"J Knee Surg"},{"key":"pone.0257202.ref019","doi-asserted-by":"crossref","first-page":"182","DOI":"10.4103\/ortho.IJORTHO_46_16","article-title":"Enhanced recovery protocol and hidden blood loss in patients undergoing total knee arthroplasty","volume":"51","author":"R Dhawan","year":"2017","journal-title":"Indian J Orthop"},{"key":"pone.0257202.ref020","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1097\/01.blo.0000147701.24029.cc","article-title":"Soft Tissue and Intra-articular Injection of Bupivacaine, Epinephrine, and Morphine Has a Beneficial Effect after Total Knee Arthroplasty","author":"V Lombardi A","year":"2004","journal-title":"Clin Orthop Relat Res"},{"key":"pone.0257202.ref021","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1093\/bja\/aev408","article-title":"A randomized trial of the effect of low dose epinephrine infusion in addition to tranexamic acid on blood loss during total hip arthroplasty","volume":"116","author":"O Jans","year":"2016","journal-title":"Br J Anaesth"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0257202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T14:05:29Z","timestamp":1631196329000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0257202"}},"subtitle":[],"editor":[{"given":"Robert Jeenchen","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,9,9]]},"references-count":21,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2021,9,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0257202","relation":{"has-review":[{"id-type":"doi","id":"10.32388\/FIO58D","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,9]]}}}