{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:12:12Z","timestamp":1791389532568,"version":"4.3.3"},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T00:00:00Z","timestamp":1631491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Coordination for the Improvement of Higher Education Personnel \u2013 Brazil","award":["Finance Code 001"],"award-info":[{"award-number":["Finance Code 001"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Neonatal screening is essential for child health and has the following purposes: (1) pulse oximetry screening to evaluate congenital heart diseases; (2) red reflex examination to investigate eye diseases; (3) newborn hearing screening test to evaluate congenital hearing diseases; (4) tongue test to evaluate the lingual frenulum and identify communication and feeding problems; (5) the Guthrie test to screen for metabolic diseases. This study investigated the prevalence of the five neonatal screening tests and its associated institutional and socio-cultural factors using a cross-sectional study with 415 mother and baby binomials from public maternity hospitals in Natal, RN, Brazil in 2019. Pearson\u2019s chi-squared, Mann-Whitney and Poisson regression tests were used, with a significance of p \u2264 0.05 and a 95% confidence interval. The sample loss was 71 mothers (17%). The prevalence in the first week and at the end of 28 days was 93% and 99.5% (pulse oximetry screening), 60% and 97.6% (red reflex examination), 71.9% and 93.6% (Guthrie test), 35.5% and 68.2% (hearing screening test), and 19% and 48.9% (tongue test). Only 152 newborns (36.6%) underwent all five tests. The performance of the tests was associated in the final model (p \u2264 0.05) with the residence of the mothers in the state capital (PR = 1.36; 95% CI = 1.18\u20131.56) and the provision of guidance for mothers about the five tests in maternity hospitals (PR = 1.30; 95% CI = 1.08\u20131.67). None of the tests met full coverage, and regional inequities were identified indicating the need to restructure the institutions, training and qualification procedures to improve of the work processes and longitudinal care.<\/jats:p>","DOI":"10.1371\/journal.pone.0257282","type":"journal-article","created":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T17:29:07Z","timestamp":1631554147000},"page":"e0257282","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prevalence of the five newborn screening tests"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0564-4828","authenticated-orcid":true,"given":"Josilene Maria Ferreira","family":"Pinheiro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiana Brito Men\u00eazes","family":"Flor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiane da Silva Ramos","family":"Marinho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa Cristina da Costa","family":"Pires","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luana Isabelly Carneiro de","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara R\u00fabia de Oliveira","family":"Bezerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9ssica Rodrigues","family":"Clementino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1bia Barbosa de","family":"Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,9,13]]},"reference":[{"issue":"2","key":"pone.0257282.ref001","first-page":"128.e1","article-title":"Newborn screening for metabolic disorders in Spain and worldwide","volume":"91","author":"DE Casti\u00f1eras","year":"2019","journal-title":"An. 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Minist\u00e9rio da Sa\u00fade (MS). Nota T\u00e9cnica N0 7\/2018. CGSCAM\/DAPES\/SAS. [website]. Bras\u00edlia; 2018 [cited 2019 Set 20]. Available from: https:\/\/portalarquivos2.saude.gov.br\/images\/pdf\/2018\/junho\/12\/SEI-MS-2937931-Nota-Tecnica.pdf."},{"key":"pone.0257282.ref006","unstructured":"Brasil. Lei N. 13.002 de 20 de junho de 2014 [website]. Bras\u00edlia; 2014 [cited 2019 Out 26]. Available from: http:\/\/www.planalto.gov.br\/CCIVIL_03\/_Ato2011-2014\/2014\/Lei\/L13002.htm."},{"issue":"1","key":"pone.0257282.ref007","doi-asserted-by":"crossref","first-page":"77","DOI":"10.23925\/2176-2724.2019v31i1p77-86","article-title":"Fr\u00eanulo lingual e sua rela\u00e7\u00e3o com aleitamento materno: compreens\u00e3o de uma equipe de sa\u00fade","volume":"31","author":"IK Karkow","year":"2019","journal-title":"Dist\u00farb. 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