{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T23:15:46Z","timestamp":1778800546289,"version":"3.51.4"},"reference-count":20,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T00:00:00Z","timestamp":1632182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"New Wellness Concept S.L"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>A new line of treatment for premature ejaculation (PE) based on the use of masturbation aid device in combination with behavioral techniques has emerged in recent years. We report a multicenter randomized clinical trial with a parallel group design to determine the effectiveness of an electronic device called Myhixel I\u00a9 in the treatment of PE. Forty patients who met the criteria for the diagnosis of lifelong PE, were assigned to two treatment groups completed the Sphincter control training (SCT) program in eight weeks. The only difference between groups was the use of the device. The main measure was the \u201cfold increase\u201d (FI) of the intravaginal ejaculatory latency time (IELT). The geometric means of IELT show, at the end of the treatment at week 8, a superiority of the device group. The mean FI 4.27 (SD 2.59) at the end of treatment for the device group was clearly higher than obtained in the previous clinical trial, in which a specific medical device was not used. No side effects were observed and it required little therapeutic input and no partner involvement. The SCT program in combination with the Myhixel I\u00a9 is an effective treatment for PE.<\/jats:p>","DOI":"10.1371\/journal.pone.0257284","type":"journal-article","created":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T18:13:40Z","timestamp":1632248020000},"page":"e0257284","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Efficacy of Sphincter Control Training and medical device in the treatment of premature ejaculation: A multicenter randomized controlled clinical trial"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8404-1413","authenticated-orcid":true,"given":"Jes\u00fas E.","family":"Rodr\u00edguez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9949-9689","authenticated-orcid":true,"given":"Jose A.","family":"Picazo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4284-6744","authenticated-orcid":true,"given":"Juan C.","family":"Marzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 A.","family":"Piqueras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leandro","family":"Reina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo","family":"Hidalgo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo","family":"Tornero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2021,9,21]]},"reference":[{"issue":"4","key":"pone.0257284.ref001","doi-asserted-by":"crossref","first-page":"416","DOI":"10.21037\/tau.2016.05.16","article-title":"Classification and definition of premature ejaculation","volume":"5","author":"A Parnham","year":"2016","journal-title":"Transl Androl Urol"},{"key":"pone.0257284.ref002","article-title":"Management Options for Premature Ejaculation and Delayed Ejaculation in Men","author":"P Martin-Tuite","year":"2019","journal-title":"Sex Med Rev"},{"issue":"10","key":"pone.0257284.ref003","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1080\/14656566.2018.1494725","article-title":"Drug treatment options for premature ejaculation","volume":"19","author":"MD Waldinger","year":"2018","journal-title":"Expert Opin Pharmacother"},{"issue":"6","key":"pone.0257284.ref004","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1111\/jsm.12504","article-title":"An update of the International Society of Sexual Medicine\u2019s guidelines for the diagnosis and treatment of premature ejaculation (PE).","volume":"11","author":"SE Althof","year":"2014","journal-title":"J Sex Med."},{"issue":"1","key":"pone.0257284.ref005","first-page":"129","article-title":"Novel Treatment for Premature Ejaculation in the Light of Currently Used Therapies: A Review. 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