{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T02:00:00Z","timestamp":1793325600536,"version":"4.5.0"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T00:00:00Z","timestamp":1637107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Benter Foundation","award":["2020-01"],"award-info":[{"award-number":["2020-01"]}],"id":[{"id":"https:\/\/ror.org\/03qg3n392","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Herpes zoster (HZ) infection increases dementia risk, but it is not known if herpes zoster vaccination is associated with lower risk for dementia. We determined if HZ vaccination, compared to no HZ vaccination, is associated with lower risk for incident dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods and findings<\/jats:title>\n                    <jats:p>Data was obtained from Veterans Health Affairs (VHA) medical records (10\/1\/2008\u20139\/30\/2019) with replication in MarketScan\u00ae commercial and Medicare claims (1\/1\/2009-12\/31\/2018). Eligible patients were \u226565 years of age and free of dementia for two years prior to baseline (VHA n = 136,016; MarketScan n = 172,790). Two index periods (either start of 2011 or 2012) were defined, where patients either had or did not have a HZ vaccination. Confounding was controlled with propensity scores and inverse probability of treatment weighting. Competing risk (VHA) and Cox proportional hazard (MarketScan) models estimated the association between HZ vaccination and incident dementia in all patients and in age (65\u201369, 70\u201374, \u226575) and race (White, Black, Other) sub-groups. Sensitivity analysis measured the association between HZ vaccination and incident Alzheimer\u2019s dementia (AD). HZ vaccination at index versus no HZ vaccination throughout follow-up. VHA patients mean age was 75.7 (SD\u00b17.4) years, 4.0% were female, 91.2% white and 20.2% had HZ vaccination. MarketScan patients mean age was 69.9 (SD\u00b15.7) years, 65.0% were female and 14.2% had HZ vaccination. In both cohorts, HZ vaccination compared with no vaccination, was significantly associated with lower dementia risk (VHA HR = 0.69; 95%CI: 0.67\u20130.72; MarketScan HR = 0.65; 95%CI:0.57\u20130.74). HZ vaccination was not related to dementia risk in MarketScan patients aged 65\u201369 years. No difference in HZ vaccination to dementia effects were found by race. HZ vaccination was associated with lower risk for AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HZ vaccination is associated with reduced risk of dementia. Vaccination may provide nonspecific neuroprotection by training the immune system to limit damaging inflammation, or specific neuroprotection that prevents viral cytopathic effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0257405","type":"journal-article","created":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T13:29:26Z","timestamp":1637155766000},"page":"e0257405","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":89,"title":["Impact of herpes zoster vaccination on incident dementia: A retrospective study in two patient cohorts"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9148-2863","authenticated-orcid":true,"given":"Jeffrey F.","family":"Scherrer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Salas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy L.","family":"Wiemken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel F.","family":"Hoft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E.","family":"Morley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,11,17]]},"reference":[{"key":"pone.0257405.ref001","unstructured":"World Health Organization. Dementia. Key Facts. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/dementia#:~:text=Worldwide%2C%20around%2050%20million%20people, dependency%20among%20older%20people%20worldwide. accessed 10\/10\/2020. 2020."},{"key":"pone.0257405.ref002","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1093\/epirev\/mxs007","article-title":"Can infections cause Alzheimer\u2019s disease?","volume":"35","author":"F Mawanda","year":"2013","journal-title":"Epidemiol Rev"},{"issue":"7","key":"pone.0257405.ref003","doi-asserted-by":"crossref","first-page":"996","DOI":"10.2174\/1570159X15666170313122937","article-title":"The Infectious Etiology of Alzheimer\u2019s Disease","volume":"15","author":"M Sochocka","year":"2017","journal-title":"Curr Neuropharmacol"},{"key":"pone.0257405.ref004","doi-asserted-by":"crossref","first-page":"362","DOI":"10.3389\/fgene.2018.00362","article-title":"Role of Microbes in the Development of Alzheimer\u2019s Disease: State of the Art\u2014An International Symposium Presented at the 2017 IAGG Congress in San Francisco","volume":"9","author":"T Fulop","year":"2018","journal-title":"Front Genet"},{"issue":"4","key":"pone.0257405.ref005","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.jalz.2008.12.001","article-title":"Alzheimer\u2019s disease and infection: do infectious agents contribute to progression of Alzheimer\u2019s disease?","volume":"5","author":"K Honjo","year":"2009","journal-title":"Alzheimers Dement"},{"issue":"1","key":"pone.0257405.ref006","doi-asserted-by":"crossref","first-page":"e12119","DOI":"10.1002\/trc2.12119","article-title":"Herpesvirus infections, antiviral treatment, and the risk of dementia-a registry-based cohort study in Sweden","volume":"7","author":"K Lopatko Lindman","year":"2021","journal-title":"Alzheimers Dement (N Y)"},{"issue":"6","key":"pone.0257405.ref007","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.jalz.2014.07.157","article-title":"Herpes simplex infection and the risk of Alzheimer\u2019s disease: A nested case-control study","volume":"11","author":"H L\u00f6vheim","year":"2015","journal-title":"Alzheimers Dement"},{"key":"pone.0257405.ref008","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.trci.2019.09.014","article-title":"A genetic signature including apolipoprotein Eepsilon4 potentiates the risk of herpes simplex-associated Alzheimer\u2019s disease.","volume":"5","author":"K Lopatko Lindman","year":"2019","journal-title":"Alzheimers Dement (N Y)"},{"issue":"1","key":"pone.0257405.ref009","article-title":"Herpes Zoster and Dementia: A Nationwide Population-Based Cohort Study","volume":"79","author":"VC Chen","year":"2018","journal-title":"J Clin Psychiatry"},{"key":"pone.0257405.ref010","article-title":"Association of herpes zoster with dementia and effect of antiviral therapy on dementia: a population-based cohort study","author":"S Bae","year":"2020","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"issue":"11","key":"pone.0257405.ref011","doi-asserted-by":"crossref","first-page":"e0188490","DOI":"10.1371\/journal.pone.0188490","article-title":"Increased risk of dementia following herpes zoster ophthalmicus","volume":"12","author":"MC Tsai","year":"2017","journal-title":"PLoS One."},{"issue":"11","key":"pone.0257405.ref012","first-page":"1495","article-title":"Past exposure to vaccines and subsequent risk of Alzheimer\u2019s disease","volume":"165","author":"R Verreault","year":"2001","journal-title":"CMAJ: Canadian Medical Association Journal"},{"issue":"9","key":"pone.0257405.ref013","doi-asserted-by":"crossref","first-page":"e2868","DOI":"10.1097\/MD.0000000000002868","article-title":"Influenza Vaccination Reduces Dementia Risk in Chronic Kidney Disease Patients: A Population-Based Cohort Study","volume":"95","author":"JC Liu","year":"2016","journal-title":"Medicine (Baltimore)."},{"issue":"4","key":"pone.0257405.ref014","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1136\/jim-2019-001155","article-title":"Influenza vaccination reduces dementia in patients with chronic obstructive pulmonary disease: a nationwide cohort study","volume":"68","author":"CS Luo","year":"2020","journal-title":"J Investig Med"},{"issue":"14","key":"pone.0257405.ref015","doi-asserted-by":"crossref","first-page":"2984","DOI":"10.1016\/j.vaccine.2020.02.057","article-title":"The adult vaccination landscape in the United States during the Affordable Care Act era: Results from a large retrospective database analysis","volume":"38","author":"E Aris","year":"2020","journal-title":"Vaccine"},{"issue":"4","key":"pone.0257405.ref016","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1370\/afm.2415","article-title":"Association Between Metformin Initiation and Incident Dementia Among African American and White Veterans Health Administration Patients","volume":"17","author":"JF Scherrer","year":"2019","journal-title":"Ann Fam Med"},{"issue":"2","key":"pone.0257405.ref017","doi-asserted-by":"crossref","first-page":"100430","DOI":"10.1016\/j.hjdsi.2020.100430","article-title":"Methods to identify dementia in the electronic health record: Comparing cognitive test scores with dementia algorithms","volume":"8","author":"BN Harding","year":"2020","journal-title":"Healthc (Amst)"},{"key":"pone.0257405.ref018","unstructured":"Risk Reduction of Cognitive Decline and Dementia: WHO Guidelines. WHO Guidelines Approved by the Guidelines Review Committee. Geneva2019."},{"issue":"5","key":"pone.0257405.ref019","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.ypmed.2012.03.008","article-title":"Characteristics associated with the uptake of influenza vaccination among adults in the United States","volume":"54","author":"M Takayama","year":"2012","journal-title":"Prev Med"},{"issue":"446","key":"pone.0257405.ref020","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1080\/01621459.1999.10474144","article-title":"A Proportional Hazards Model for the Subdistribution of a Competing Risk","volume":"94","author":"JP Fine","year":"1999","journal-title":"Journal of the American Statistical Association"},{"issue":"3","key":"pone.0257405.ref021","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jalz.2015.12.007","article-title":"Inequalities in dementia incidence between six racial and ethnic groups over 14 years","volume":"12","author":"ER Mayeda","year":"2016","journal-title":"Alzheimers Dement"},{"issue":"28","key":"pone.0257405.ref022","doi-asserted-by":"crossref","first-page":"3661","DOI":"10.1002\/sim.6607","article-title":"Moving towards best practice when using inverse probability of treatment weighting (IPTW) using the propensity score to estimate causal treatment effects in observational studies","volume":"34","author":"PC Austin","year":"2015","journal-title":"Stat Med"},{"issue":"6","key":"pone.0257405.ref023","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1037\/0022-3514.51.6.1173","article-title":"The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations","volume":"51","author":"RM Baron","year":"1986","journal-title":"J Pers Soc Psychol"},{"issue":"1","key":"pone.0257405.ref024","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing","volume":"57","author":"Y Benjamini","year":"1995","journal-title":"Journal of the Royal Statistical Society Series B (Methodological)"},{"issue":"11","key":"pone.0257405.ref025","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1002\/sim.7625","article-title":"Addressing the estimation of standard errors in fixed effects meta-analysis","volume":"37","author":"C Dominguez Islas","year":"2018","journal-title":"Stat Med"},{"issue":"6","key":"pone.0257405.ref026","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1001\/jama.2018.21554","article-title":"Using the E-Value to Assess the Potential Effect of Unmeasured Confounding in Observational Studies","volume":"321","author":"S Haneuse","year":"2019","journal-title":"Jama"},{"key":"pone.0257405.ref027","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1097\/EDE.0000000000001032","article-title":"Bounding bias due to selection","volume":"30","author":"LH Smith","year":"2019","journal-title":"Epidemiology"},{"issue":"18","key":"pone.0257405.ref028","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1016\/j.vaccine.2017.03.013","article-title":"Lower vaccine uptake amongst older individuals living alone: A systematic review and meta-analysis of social determinants of vaccine uptake","volume":"35","author":"A Jain","year":"2017","journal-title":"Vaccine"},{"issue":"11","key":"pone.0257405.ref029","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1002\/pds.4653","article-title":"Differential uptake of herpes zoster vaccination associated with socioeconomic status: A population-based study in Stockholm County, Sweden","volume":"27","author":"S Fogelberg","year":"2018","journal-title":"Pharmacoepidemiol Drug Saf"},{"issue":"1","key":"pone.0257405.ref030","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.amepre.2020.01.017","article-title":"Shingles Vaccination of U.S. Adults Aged 50\u201359 Years and >\/ = 60 Years Before Recommendations for Use of Recombinant Zoster Vaccine","volume":"59","author":"PJ Lu","year":"2020","journal-title":"Am J Prev Med"},{"issue":"18","key":"pone.0257405.ref031","first-page":"9601","article-title":"Inflammation, apoptosis and autophagy as critical players in vascular dementia","volume":"24","author":"XX Wang","year":"2020","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"pone.0257405.ref032","first-page":"136","article-title":"Role of pro-inflammatory cytokines released from microglia in Alzheimer\u2019s disease","volume":"3","author":"WY Wang","year":"2015","journal-title":"Ann Transl Med"},{"issue":"9","key":"pone.0257405.ref033","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.it.2013.04.004","article-title":"A small jab\u2014a big effect: nonspecific immunomodulation by vaccines","volume":"34","author":"CS Benn","year":"2013","journal-title":"Trends Immunol"}],"container-title":["PLOS 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