{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T18:33:52Z","timestamp":1793126032865,"version":"4.5.0"},"reference-count":98,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T00:00:00Z","timestamp":1632268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Pan African University Life and Earth Sciences Institute"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\"><jats:title>Background<\/jats:title><jats:p>Adolescent pregnancy is considered a major contributor to maternal and child morbidity and mortality, the greatest concern of developing countries and an important public health issue globally. Adolescents are responsible for eleven percent of births worldwide and they face several pregnancy and childbirth related complications. However, in low-income countries like Ethiopia, there are limited researches conducted to investigate outcomes of adolescent pregnancy. Therefore, this study was conducted to assess the adverse maternal outcomes of adolescent pregnancy in Northwest Ethiopia.<\/jats:p><\/jats:sec><jats:sec id=\"sec002\"><jats:title>Methods<\/jats:title><jats:p>A prospective cohort study was conducted in 12 health facilities from seven districts in East Gojjam zone, Northwest Ethiopia. A total of 418 adolescents (15\u201319 years old) and 836 adult women (20\u201334 years old) who attended randomly selected health facilities in East Gojjam zone were included. Data were collected starting from admission to the maternity ward for labor and delivery, and postnatal depression was measured at six weeks\u2019 postpartum period using the Edinburgh Postnatal Depression Scale. Generalized estimating equations (GEE) was used to account for the within subject correlation and assess the effect of different known factors that could influence the outcome of this study.<\/jats:p><\/jats:sec><jats:sec id=\"sec003\"><jats:title>Results<\/jats:title><jats:p>A lower percentage of adolescent (58.4%) than adult (71.2%) women had their first antenatal care booking before 16 weeks of gestation. After adjusting for different confounding factors, the adverse outcome that was significantly associated with adolescent pregnancy was postpartum depression (AOR: 2.29; 95% CI, 1.42, 3.7,<jats:italic>p-value = 0<\/jats:italic>.<jats:italic>001)<\/jats:italic>. Assisted vaginal delivery (AOR: 0.44; 95% CI, 0.23, 0.86,<jats:italic>p-value 0<\/jats:italic>.<jats:italic>016)<\/jats:italic>and cesarean section (AOR: 0.43; 95% CI, 0.19, 0.97,<jats:italic>p-value = 0<\/jats:italic>.<jats:italic>042)<\/jats:italic>were significantly lower among adolescent women.<\/jats:p><\/jats:sec><jats:sec id=\"sec004\"><jats:title>Conclusions<\/jats:title><jats:p>Adolescent pregnancy is associated with higher odds of postpartum depression, and lower odds to undergo cesarean section and assisted vaginal delivery than adult women. Perinatal care services should be more adolescent-friendly to ensure early diagnosis and treatment of postpartum depression. School and community-based awareness programs regarding use of contraception to prevent unwanted adolescent pregnancy, early antenatal care booking and adverse pregnancy outcomes of adolescent pregnancy and provision of psychosocial support are recommended.<\/jats:p><\/jats:sec>","DOI":"10.1371\/journal.pone.0257485","type":"journal-article","created":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T18:31:58Z","timestamp":1632335518000},"page":"e0257485","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":21,"title":["Adverse maternal outcomes of adolescent pregnancy in Northwest Ethiopia: A prospective cohort study"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8095-7376","authenticated-orcid":true,"given":"Getachew Mullu","family":"Kassa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayodele O.","family":"Arowojolu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akin Tunde A.","family":"Odukogbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alemayehu Worku","family":"Yalew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,9,22]]},"reference":[{"issue":"1","key":"pone.0257485.ref001","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1186\/s12978-018-0640-2","article-title":"Prevalence and determinants of adolescent pregnancy in Africa: a systematic review and Meta-analysis.","volume":"15","author":"GM Kassa","year":"2018","journal-title":"Reproductive Health."},{"key":"pone.0257485.ref002","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1016\/j.ijgo.2015.02.006","article-title":"Adolescent sexual and reproductive health: The global challenges.","volume":"131","author":"JL Morris","year":"2015","journal-title":"International Journal of Gynecology & Obstetrics."},{"issue":"4","key":"pone.0257485.ref003","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1590\/S1679-45082015RW3127","article-title":"Complications in adolescent pregnancy: systematic review of the literature.","volume":"13","author":"WF Azevedo","year":"2015","journal-title":"Einstein (Sao Paulo)."},{"issue":"Suppl 2","key":"pone.0257485.ref004","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1186\/1742-4755-12-S2-S8","article-title":"Adverse maternal and perinatal outcomes in adolescent pregnancies: The Global Network\u2019s Maternal Newborn Health Registry study.","volume":"12","author":"F Althabe","year":"2015","journal-title":"Reprod Health."},{"key":"pone.0257485.ref005","unstructured":"WHO. 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