{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:01:19Z","timestamp":1788998479448,"version":"build-2803163510"},"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T00:00:00Z","timestamp":1632096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Introduction<\/jats:title>\n<jats:p>Thrombocytopenia and leucopenia are frequently encountered hematological disorders among people living with HIV\/AIDS. This systematic review and meta-analysis were aimed to indicate the national prevalence of thrombocytopenia and leucopenia among HIV\/AIDS patients.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>This systematic review and meta-analysis was conducted following the preferred reporting items for systematic review and meta-analysis (PRISMA) guidelines. A systematic search was conducted from February 01, 2021 to April 02, 2021 using electronic databases Google Scholar, PubMed, Web of Sciences, Google, EMBASE, SCOPUS and ResearchGate. The quality of the included studies was assessed using Newcastle\u2014Ottawa Quality Assessment Scale (NOS) adapted for cross-sectional studies. Data analysis was done using STATA version 14 using metan commands. Random effect meta-analysis was used to estimate the pooled prevalence of thrombocytopenia and leucopenia among people living with HIV\/AIDS in Ethiopia.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Result<\/jats:title>\n<jats:p>Of the 349 initially searched articles, 90 were assessed for eligibility and only 13 articles published from 2014 to 2020 were included in the final meta-analysis. A total of 3854 participants were involved in the included studies. The pooled prevalence of thrombocytopenia was 9.69% (95%CI; 7.40\u201311.97%). Significant heterogeneity was observed with I<jats:sup>2<\/jats:sup> value of 84.7%. Thrombocytopenia was 11.91% and 5.95% prevalent among HAART naive and HAART exposed HIV\/AIDS patients, respectively. The pooled prevalence of leucopenia among HIV\/AIDS patients was 17.31% (95%CI: 12.37\u201322.25%).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>This study showed a high prevalence of thrombocytopenia and leucopenia among people living with HIV\/AIDS, indicating the necessity of regular screening of HIV seropositive patients for different hematological parameters and providing treatment.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0257630","type":"journal-article","created":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T18:21:10Z","timestamp":1632162070000},"page":"e0257630","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["The prevalence of thrombocytopenia and leucopenia among people living with HIV\/AIDS in Ethiopia: A systematic review and meta-analysis"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3647-5924","authenticated-orcid":true,"given":"Habtye","family":"Bisetegn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4360-7422","authenticated-orcid":true,"given":"Hussien","family":"Ebrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,9,20]]},"reference":[{"issue":"4","key":"pone.0257630.ref001","first-page":"756","article-title":"Hematologic derangements in HIV\/AIDS patients and their relationship with the CD4 counts: a cross-sectional study","volume":"13","author":"S Bhardwaj","year":"2020","journal-title":"International journal of clinical and experimental pathology"},{"issue":"1","key":"pone.0257630.ref002","doi-asserted-by":"crossref","first-page":"34","DOI":"10.4103\/0974-2727.115929","article-title":"Association of hematological profile of human immunodeficiency virus-positive patients with clinicoimmunologic stages of the disease","volume":"5","author":"SE Mathews","year":"2013","journal-title":"Journal of laboratory physicians"},{"issue":"12","key":"pone.0257630.ref003","doi-asserted-by":"crossref","first-page":"E809","DOI":"10.1016\/S2352-3018(19)30230-9","article-title":"The global burden of HIV and prospects for control","volume":"6","author":"APG Abhishek Pandey","year":"2019","journal-title":"The Lancet"},{"issue":"2","key":"pone.0257630.ref004","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1053\/beha.1999.0069","article-title":"Haematological aspects of HIV infection","volume":"13","author":"RH Evans","year":"2000","journal-title":"Best Practice & Research Clinical Haematology"},{"issue":"6","key":"pone.0257630.ref005","doi-asserted-by":"crossref","first-page":"465","DOI":"10.7196\/SAMJ.5595","article-title":"Haematological complications of HIV infection","volume":"102","author":"J Opie","year":"2012","journal-title":"SAMJ: South African Medical Journal"},{"issue":"3","key":"pone.0257630.ref006","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/jth.12813","article-title":"Severe bleeding events in adults and children with primary immune thrombocytopenia: a systematic review","volume":"13","author":"C Neunert","year":"2015","journal-title":"Journal of Thrombosis and Haemostasis"},{"issue":"8","key":"pone.0257630.ref007","article-title":"HIV and haematopoiesis","volume":"109","author":"JCP C Durandt","year":"2019","journal-title":"SAMJ: South African medical Journal"},{"key":"pone.0257630.ref008","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1054\/blre.2001.0188","volume":"16","author":"A Scaradavou","year":"2002","journal-title":"HIV-related thrombocytopenia. 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