{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T06:32:58Z","timestamp":1776666778421,"version":"3.51.2"},"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T00:00:00Z","timestamp":1632960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>An association was reported between the left ventricular longitudinal strain (LV-LS) and preload. LV-LS reflects the left cardiac function curve as it is the ratio of shortening over diastolic dimension. The aim of this study was to determine the sensitivity and specificity of LV-LS variations after a passive leg raising (PLR) maneuver to predict fluid responsiveness in intensive care unit (ICU) patients with acute circulatory failure (ACF).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Patients with ACF were prospectively included. Preload-dependency was defined as a velocity time integral (VTI) variation greater than 10% between baseline (T0) and PLR (T1), distinguishing the preload-dependent (PLD+) group and the preload-independent (PLD-) group. A 7-cycles, 4-chamber echocardiography loop was registered at T0 and T1, and strain analysis was performed off-line by a blind clinician. A general linear model for repeated measures was used to compare the LV-LS variation (T0 to T1) between the two groups.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>From June 2018 to August 2019, 60 patients (PLD+ = 33, PLD- = 27) were consecutively enrolled. The VTI variations after PLR were +21% (\u00b18) in the PLD+ group and -1% (\u00b17) in the PLD- group (<jats:italic>p<\/jats:italic>&lt;0.01). Mean baseline LV-LS was -11.3% (\u00b14.2) in the PLD+ group and -13.0% (\u00b14.2) in the PLD- group (<jats:italic>p<\/jats:italic> = 0.12). LV-LS increased in the whole population after PLR +16.0% (\u00b14.0) (<jats:italic>p<\/jats:italic> = 0.04). The LV-LS variations after PLR were +19.0% (\u00b131) (<jats:italic>p<\/jats:italic> = 0.05) in the PLD+ group and +11.0% (\u00b138) (<jats:italic>p<\/jats:italic> = 0.25) in the PLD- group, with no significant difference between the two groups (<jats:italic>p<\/jats:italic> = 0.08). The area under the curve for the LV-LS variations between T0 and T1 was 0.63 [0.48\u20130.77].<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Our study confirms that LV-LS is load-dependent; however, the variations in LV-LS after PLR is not a discriminating criterion to predict fluid responsiveness of ICU patients with ACF in this cohort.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0257737","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T18:38:04Z","timestamp":1633027084000},"page":"e0257737","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Left ventricular longitudinal strain variations assessed by speckle-tracking echocardiography after a passive leg raising maneuver in patients with acute circulatory failure to predict fluid responsiveness: A prospective, observational 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