{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T14:21:19Z","timestamp":1791814879401,"version":"4.3.4"},"reference-count":22,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T00:00:00Z","timestamp":1633392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Leonard Davis Institute of Health Economics, University of Pennsylvania","award":["Pilot Grant"],"award-info":[{"award-number":["Pilot Grant"]}]},{"DOI":"10.13039\/100006093","name":"Patient-Centered Outcomes Research Institute","doi-asserted-by":"publisher","award":["Pilot Study Award"],"award-info":[{"award-number":["Pilot Study Award"]}],"id":[{"id":"10.13039\/100006093","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01-AI-136626"],"award-info":[{"award-number":["R01-AI-136626"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["T32 AG051090"],"award-info":[{"award-number":["T32 AG051090"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"NIMH","doi-asserted-by":"crossref","award":["R01 MH117014"],"award-info":[{"award-number":["R01 MH117014"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Lifespan Brain Institute (LiBI) of the Children\u2019s Hospital of Philadelphia and Penn Medicine"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Most patients with hepatitis C virus (HCV) infection perceive some degree of disease-related stigma. Misunderstandings about diseases may contribute to disease-related stigma. The objective of this study was to evaluate patient-level knowledge about HCV infection transmission and natural history and its association with HCV-related stigma among HCV-infected patients. We conducted a cross-sectional survey study among 265 patients with HCV in Philadelphia using the HCV Stigma Scale and the National Health and Nutrition Examination Survey (NHANES) Hepatitis C Follow-up Survey (2001\u20132008). The association between HCV knowledge and HCV-related stigma was evaluated via linear regression. Overall knowledge about HCV transmission and natural history was high, with &gt;80% of participants answering \u22659 of 11 items correctly (median number of correct responses, 9 [82%]), HCV-related knowledge was similar between HIV\/HCV-coinfected and HCV-monoinfected participants (p = 0.30). A higher level of HCV-related knowledge was associated with greater perceived HCV-related stigma (\u03b2, 2.34 ([95% CI, 0.51\u20134.17]; p = 0.013). Results were similar after adjusting for age, race, ethnicity, HIV status, education level, stage of HCV management, time since diagnosis, and history of injection drug use. In this study, increased HCV-related knowledge was associated with greater perceptions of HCV stigma. Clinicians may consider allotting time to address common misconceptions about HCV when educating patients about HCV infection, which may counterbalance the stigmatizing impact of greater HCV-related knowledge.<\/jats:p>","DOI":"10.1371\/journal.pone.0258143","type":"journal-article","created":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T03:14:31Z","timestamp":1633490071000},"page":"e0258143","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["The impact of disease-related knowledge on perceptions of stigma among patients with Hepatitis C Virus (HCV) infection"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1037-5610","authenticated-orcid":true,"given":"M. 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The longitudinal impact of public stigma on self-stigma","volume":"60","author":"DL Vogel","year":"2013","journal-title":"J Couns Psychol"},{"key":"pone.0258143.ref012","doi-asserted-by":"crossref","first-page":"39","DOI":"10.2147\/IJGM.S127689","article-title":"Hepatitis C treatment: where are we now?","volume":"10","author":"NJ Burstow","year":"2017","journal-title":"Int J Gen Med"},{"key":"pone.0258143.ref013","volume-title":"Eliminating the Public Health Problem of Hepatitis B and C in the United States","author":"National Academies of Sciences, Engineering, and Medicine","year":"2016"},{"issue":"6","key":"pone.0258143.ref014","doi-asserted-by":"crossref","DOI":"10.1093\/ofid\/ofy076","article-title":"Absolute Insurer Denial of Direct-Acting Antiviral Therapy for Hepatitis C: A National Specialty Pharmacy Cohort Study","volume":"5","author":"C Gowda","year":"2018","journal-title":"Open Forum Infectious Diseases"},{"issue":"7","key":"pone.0258143.ref015","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.cgh.2016.03.040","article-title":"Disparities in Absolute Denial of Modern Hepatitis C Therapy by Type of Insurance","volume":"14","author":"V Lo Re","year":"2016","journal-title":"Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association"},{"issue":"10","key":"pone.0258143.ref016","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1046\/j.1525-1497.2003.20826.x","article-title":"\u201cThey Treated Me Like a Leper\u201d: Stigmatization and the Quality of Life of Patients with Hepatitis C","volume":"18","author":"S Zickmund","year":"2003","journal-title":"Journal of General Internal Medicine"},{"key":"pone.0258143.ref017","doi-asserted-by":"crossref","first-page":"103238","DOI":"10.1016\/j.drugpo.2021.103238","article-title":"\"Stigma is where the harm comes from\": Exploring expectations and lived experiences of hepatitis C virus post-treatment trajectories among people who inject drugs","author":"T Goodyear","year":"2021","journal-title":"Int J Drug Policy"},{"issue":"8","key":"pone.0258143.ref018","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1080\/08870446.2015.1012195","article-title":"The Hepatitis C treatment experience: Patients\u2019 perceptions of the facilitators of and barriers to uptake, adherence and completion","volume":"30","author":"VA Sublette","year":"2015","journal-title":"Psychology & health"},{"issue":"5","key":"pone.0258143.ref019","doi-asserted-by":"crossref","first-page":"e97317","DOI":"10.1371\/journal.pone.0097317","article-title":"The Hepatitis C Cascade of Care: Identifying Priorities to Improve Clinical Outcomes","volume":"9","author":"BP Linas","year":"2014","journal-title":"PLOS ONE."},{"issue":"8","key":"pone.0258143.ref020","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.cgh.2013.04.024","article-title":"Education Provides Significant Benefits to Patients With Hepatitis B Virus or Hepatitis C Virus Infection: A Systematic Review","volume":"11","author":"HA Shah","year":"2013","journal-title":"Clinical Gastroenterology and Hepatology"},{"issue":"7","key":"pone.0258143.ref021","doi-asserted-by":"crossref","first-page":"e101554","DOI":"10.1371\/journal.pone.0101554","article-title":"The treatment cascade for chronic hepatitis C virus infection in the United States: a systematic review and meta-analysis","volume":"9","author":"BR Yehia","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"pone.0258143.ref022","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0277-9536(02)00304-0","article-title":"HIV and AIDS-related stigma and discrimination: a conceptual framework and implications for action","volume":"57","author":"R Parker","year":"2003","journal-title":"Social Science & Medicine"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0258143","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T03:14:59Z","timestamp":1633490099000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0258143"}},"subtitle":[],"editor":[{"given":"Judith I.","family":"Tsui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,10,5]]},"references-count":22,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,10,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0258143","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,5]]}}}