{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:01:34Z","timestamp":1787022094909,"version":"build-2736575974"},"reference-count":72,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T00:00:00Z","timestamp":1635292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002969","name":"Technologick\u00e1 Agentura \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["TA\u010cR TJ020000"],"award-info":[{"award-number":["TA\u010cR TJ020000"]}],"id":[{"id":"10.13039\/501100002969","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>The study aimed to investigate the efficacy of new mycotoxin adsorbents based on purified and activated bentonites combined with yeast and phytogenic compounds in fattening pigs. The experiment involved 96 pigs (31.2\u00b12.4 kg). Control (C) group was fed a diet naturally contaminated with mycotoxins (5 mg\/kg deoxynivalenol, DON) without an adsorbent. Treated groups received the feed with mycotoxin adsorbents: purified and activated bentonite (T1), purified and activated bentonite, yeast derivatives, phytogenic substances (T2), and purified, activated, and sulphurated bentonite with phytogenic substances (T3). Evaluated parameters involved growth performance, organ weight, small intestine and liver histopathology, complete blood count, serum biochemistry, antioxidant status of the organism and total and free DON content in urine. In all treated groups, an significant increase in intestinal GSH and GSH\/GSSG ratio was observed when compared to C. No significant effects on liver and kidney weight, complete blood count, serum or intestinal malondialdehyde concentration, or total\/free DON content in urine were observed. All adsorbents improved histopathological findings in the liver when compared to C. Moreover, T1, and T2 groups showed no presence of inflammatory reaction or necrotic changes in the livers. Although, mycotoxin adsorbents investigated in this study had no significant impact on pig growth performance, they reduced the oxidative stress, and on the tissue level they protected the jejunal tissue and liver parenchyma under deoxynivalenol challenge.<\/jats:p>","DOI":"10.1371\/journal.pone.0259132","type":"journal-article","created":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T13:37:30Z","timestamp":1635341850000},"page":"e0259132","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Protective effect of a new generation of activated and purified bentonite in combination with yeast and phytogenic substances on mycotoxin challenge in pigs"],"prefix":"10.1371","volume":"16","author":[{"given":"Pavel","family":"Horky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hana Abigail","family":"Gruberova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tereza","family":"Aulichova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5936-8024","authenticated-orcid":true,"given":"Svetlana","family":"Malyugina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Slama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1004-4835","authenticated-orcid":true,"given":"Ales","family":"Pavlik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiri","family":"Skladanka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misa","family":"Skoric","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2808-001X","authenticated-orcid":true,"given":"Sylvie","family":"Skalickova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,10,27]]},"reference":[{"key":"pone.0259132.ref001","first-page":"207","volume-title":"58th International Meat Industry Conference. 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Urbankova","year":"2018","journal-title":"Peerj"},{"key":"pone.0259132.ref039","doi-asserted-by":"crossref","DOI":"10.1186\/2193-1801-3-346","article-title":"Evaluation of mycotoxin sequestering agents for aflatoxin and deoxynivalenol: an in vitro approach","volume":"3","author":"C Kong","year":"2014","journal-title":"Springerplus."},{"issue":"12","key":"pone.0259132.ref040","doi-asserted-by":"crossref","DOI":"10.3390\/ani9121081","article-title":"Evaluation of Collagen and Elastin Content in Skin of Multiparous Minks Receiving Feed Contaminated with Deoxynivalenol (DON, vomitoxin) with or without Bentonite Supplementation","volume":"9","author":"I Taszkun","year":"2019","journal-title":"Animals"},{"key":"pone.0259132.ref041","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.tiv.2016.10.003","article-title":"Mycotoxin detoxifiers detoxifiers attenuate deoxynivalenol-induced pro-inflammatory barrier insult in porcine enterocytes as an in vitro evaluation model of feed 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Patience","year":"2014","journal-title":"Journal of Animal Science"},{"issue":"1","key":"pone.0259132.ref047","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1080\/1745039X.2017.1415550","article-title":"Effects of oral exposure to sodium sulphite-treated deoxynivalenol (DON)-contaminated maize on performance and plasma concentrations of toxins and metabolites in piglets","volume":"72","author":"M Paulick","year":"2018","journal-title":"Arch Anim Nutr"},{"issue":"1","key":"pone.0259132.ref048","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1080\/1745039X.2017.1418047","article-title":"Detoxification of Fusarium-contaminated maize with sodium sulphite\u2014in vivo efficacy with special emphasis on mycotoxin residues and piglet health","volume":"72","author":"AT Tran","year":"2018","journal-title":"Arch Anim Nutr"},{"issue":"10","key":"pone.0259132.ref049","article-title":"Effects of a Fusarium Toxin-Contaminated Maize Treated with Sodium Sulfite on Male Piglets in the 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