{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T02:05:37Z","timestamp":1771553137143,"version":"3.50.1"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T00:00:00Z","timestamp":1636934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006483","name":"Abbvie Inc","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objective<\/jats:title>\n<jats:p>To evaluate treatment satisfaction, disease outcomes, and perspectives of patients with poorly controlled rheumatoid arthritis (RA) treated with conventional synthetic, targeted synthetic, or biologic disease-modifying antirheumatic drugs (DMARDs), we conducted a subgroup (post hoc) analysis of Japanese patients participating in the SENSE study.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Data for Japanese patients (n\/N = 118\/1629) from the global, multicenter, cross-sectional, observational SENSE study were analyzed. The primary endpoint was the global satisfaction subscore assessed using the Treatment Satisfaction Questionnaire for Medication (TSQM) version 1.4. Other patient-reported outcomes included self-reported RA medication adherence and Work Productivity and Activity Impairment-RA. Patient perspectives included patients\u2019 expectations and preference of pharmacologic treatment.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Median (range) age and RA disease duration were 67.0 (18.0\u201387.0) years and 8 (0.0-54) years, respectively; 81.4% of patients were female. Mean (SD) TSQM global satisfaction subscore was 56.8 (17.5), and only 5.9% of patients reported good satisfaction with treatment (TSQM global \u226580). Mean (SD) self-reported treatment adherence using VAS was high (93.5% [13.8%]). Mean (SD) total work productivity impairment was 45.6% (32.0%); presenteeism contributed toward more total work productivity impairment (43.9% [30.4%]) than absenteeism (8.3% [24.4%]). Patients expected improvement in all parameters from their treatment, especially improvement in joint symptoms. Most patients (80.7%) preferred oral medication and 18.7% preferred monotherapy. Patient acceptability of potentially manageable side effects was high (7.5%-34.0%). Although most patients (81.3%) found combination therapy acceptable, 43.2% were receiving DMARD monotherapy.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Although most Japanese patients with RA with moderate-to-high disease activity were dissatisfied with their current DMARD treatment, high treatment adherence, high acceptability of combination therapy, high acceptability of manageable potential side effects, and preference for oral medication were reported. Data support the development of a more individualized and patient-centric approach for RA treatment.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0259389","type":"journal-article","created":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T18:30:25Z","timestamp":1637001025000},"page":"e0259389","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Patient satisfaction, preferences, expectations, characteristics, and impact of suboptimal control of rheumatoid arthritis: A subgroup analysis of Japanese patients from a large international cohort study (SENSE)"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3860-0488","authenticated-orcid":true,"given":"Yutaka","family":"Kawahito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuya","family":"Takakubo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akio","family":"Morinobu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Matsubara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orsolya","family":"Nagy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiji","family":"Sugiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2021,11,15]]},"reference":[{"issue":"11","key":"pone.0259389.ref001","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1136\/annrheumdis-2019-215920","article-title":"Global, 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Differences in treatment satisfaction, patient preferences, and treatment patterns between European, South American, and Japanese patients with suboptimally controlled rheumatoid arthritis: A subgroup analysis of the SENSE study","volume":"80","author":"PC Taylor","year":"2021","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"pone.0259389.ref033","doi-asserted-by":"crossref","first-page":"376","DOI":"10.3109\/s10165-011-0531-7","article-title":"Satisfaction and attitudes toward therapy in patients with rheumatoid arthritis","volume":"22","author":"N Takahashi","year":"2012","journal-title":"Mod Rheumatol"},{"issue":"8","key":"pone.0259389.ref034","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1002\/art.1780270805","article-title":"Severe functional declines, work disability, and increased mortality in seventy-five rheumatoid arthritis patients studied over nine years","volume":"27","author":"T Pincus","year":"1984","journal-title":"Arthritis Rheum"},{"issue":"11","key":"pone.0259389.ref035","first-page":"2108","article-title":"The longterm outcomes of rheumatoid arthritis: work disability: a prospective 18 year study of 823 patients","volume":"25","author":"F Wolfe","year":"1998","journal-title":"J Rheumatol"},{"issue":"2","key":"pone.0259389.ref036","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1136\/ard.2011.154583","article-title":"The effect of biological agents on work participation in rheumatoid arthritis patients: a systematic review","volume":"71","author":"MM ter Wee","year":"2012","journal-title":"Ann Rheum Dis"},{"issue":"11","key":"pone.0259389.ref037","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1007\/s10067-012-2048-7","article-title":"What RA patients expect of their treatment\u2014discussion over the result of our survey","volume":"31","author":"K Funahashi","year":"2012","journal-title":"Clin Rheumatol"},{"issue":"4","key":"pone.0259389.ref038","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/j.1756-185X.2012.01752.x","article-title":"Comparison of expectations of physicians and patients with rheumatoid arthritis for rheumatology clinic visits: a pilot, multicenter, international study","volume":"15","author":"H Wen","year":"2012","journal-title":"Int J Rheum Dis"},{"issue":"2","key":"pone.0259389.ref039","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/j.1365-2753.2010.01575.x","article-title":"Opinion of Japanese rheumatology physicians on methods of assessing the quality of rheumatoid arthritis care","volume":"18","author":"T Higashi","year":"2012","journal-title":"J Eval Clin Pract"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0259389","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T18:31:01Z","timestamp":1637001061000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0259389"}},"subtitle":[],"editor":[{"given":"Masataka","family":"Kuwana","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,11,15]]},"references-count":39,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,11,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0259389","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,15]]}}}