{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T19:50:34Z","timestamp":1774641034997,"version":"3.50.1"},"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T00:00:00Z","timestamp":1636934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005068","name":"Jimma University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005068","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Many studies conducted in the past focused on patients\u2019 sociodemographic factors and medical profiles to identify the determinants of suboptimal blood pressure control. However, prescribing patterns and clinicians\u2019 adherence to guidelines are also important factors affecting the rate of blood pressure control. Therefore, this study aimed to determine clinicians\u2019 prescribing patterns, patients\u2019 medication adherence, and its determinants among hypertensive patients at Jimma University Medical Center.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>A general prospective cohort study was conducted among hypertensive patients who had regular follow-up at Jimma university ambulatory cardiac clinic from March 20, 2018, to June 20, 2018. Patients\u2019 specific data was collected with a face-to-face interview and from their medical charts. Clinicians\u2019 related data were collected through a self-administered questionnaire. Data were analyzed using SPSS version 21.0. Bivariate and multivariable logistic regression analyses were done to identify key independent variables influencing patients\u2019 adherence. P-Values of less than 0.05 were considered statically significant.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>From the total of 416 patients, 237(57.0%) of them were males with a mean age of 56.50 \u00b1 11.96 years. Angiotensin-converting enzyme inhibitors were the most frequently prescribed class of antihypertensives, accounting for 261(63.7%) prescriptions. Combination therapy was used by the majority of patients, with 275 (66.1%) patients receiving two or more antihypertensive drugs. Patients\u2019 medication adherence was 46.6%, while clinicians\u2019 guideline adherence was 44.2%. Patients with merchant occupation (P = 0.020), physical inactivity (P = 0.033), and diabetes mellitus co-morbidity (P = 0.008) were significantly associated with a higher rate of medication non-adherence.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>The rate of medication adherence was poor among hypertensive patients. Physicians were not-adherent to standard treatment guideline. The most commonly prescribed class of drugs were angiotensin-converting enzyme inhibitors. Effective education should be given to patients to improve medication adherence. Prescribers should be trained on treatment guidelines regularly to keep them up-to-date with current trends of hypertension treatment and for better treatment outcomes.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0259421","type":"journal-article","created":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T18:37:07Z","timestamp":1637001427000},"page":"e0259421","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinicians\u2019 prescribing pattern, rate of patients\u2019 medication adherence and its determinants among adult hypertensive patients at Jimma University Medical Center: Prospective cohort study"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9758-4265","authenticated-orcid":true,"given":"Bekalu Kebede","family":"Simegn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Legese","family":"Chelkeba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0201-6829","authenticated-orcid":true,"given":"Bekalu Dessie","family":"Alamirew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2021,11,15]]},"reference":[{"issue":"4","key":"pone.0259421.ref001","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.gheart.2016.10.024","article-title":"The Global Burden of Disease Study and the Preventable Burden of NCD","volume":"11","author":"P Catherine","year":"2016","journal-title":"Journal of global heart"},{"issue":"3","key":"pone.0259421.ref002","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1007\/s11906-013-0340-9","article-title":"high blood pressure: the leading global burden of disease risk factor and the need for worldwide prevention programs","volume":"15","author":"S Bromfield","year":"2013","journal-title":"Curr Hypertens Rep"},{"key":"pone.0259421.ref003","first-page":"1","article-title":"Globalization and Health An overview of cardiovascular risk factor burden in sub-Saharan African countries: a socio-cultural perspective.","volume":"12","author":"R Belue","year":"2009"},{"key":"pone.0259421.ref004","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s40985-015-0014-z","article-title":"Prevalence of hypertension in Ethiopia: a systematic meta-analysis","volume":"36","author":"KT Kibret","year":"2015","journal-title":"Public Health Rev"},{"issue":"4","key":"pone.0259421.ref005","doi-asserted-by":"crossref","first-page":"514","DOI":"10.11648\/j.sjph.20150304.19","article-title":"Systematic Reviews of Prevalence and Associated Factors of Hypertension in Ethiopia: Finding the Evidence.","volume":"3","author":"M Molla","year":"2015","journal-title":"Science Journal of Public Health"},{"issue":"50","key":"pone.0259421.ref006","doi-asserted-by":"crossref","first-page":"e1959","DOI":"10.1097\/MD.0000000000001959","article-title":"Prevalence of Hypertension in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis.","volume":"94","author":"AM Sarki","year":"2015","journal-title":"Medicine (Baltimore)."},{"issue":"9841","key":"pone.0259421.ref007","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S0140-6736(12)60861-7","article-title":"Hypertension in developing countries","volume":"380","author":"MM Ibrahim","year":"2012","journal-title":"Lancet"},{"key":"pone.0259421.ref008","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1093\/eurheartj\/ehq394","article-title":"Blood pressure control and cardiovascular risk profile in hypertensive patients from central and eastern European countries","volume":"32","author":"G Grassi","year":"2011","journal-title":"Eur Heart J"},{"issue":"3","key":"pone.0259421.ref009","first-page":"1","article-title":"End Organ Damage in Hypertension","volume":"129","author":"RE Schmieder","year":"2014","journal-title":"Circulation"},{"issue":"11","key":"pone.0259421.ref010","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1038\/hr.2013.85","article-title":"Sang-Kwon Oh, Eob KC, Kim H, Jang S. 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