{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T18:33:31Z","timestamp":1778006011751,"version":"3.51.4"},"reference-count":67,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T00:00:00Z","timestamp":1638835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"univeristy of sharjah","award":["1701090226-P"],"award-info":[{"award-number":["1701090226-P"]}]},{"DOI":"10.13039\/100016714","name":"university of sharjah","doi-asserted-by":"crossref","award":["1901050144"],"award-info":[{"award-number":["1901050144"]}],"id":[{"id":"10.13039\/100016714","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p><jats:italic>Candida albicans<\/jats:italic>is the leading cause of life-threatening bloodstream candidiasis, especially among immunocompromised patients. The reversible morphological transition from yeast to hyphal filaments in response to host environmental cues facilitates<jats:italic>C<\/jats:italic>.<jats:italic>albicans<\/jats:italic>tissue invasion, immune evasion, and dissemination. Hence, it is widely considered that filamentation represents one of the major virulence properties in<jats:italic>C<\/jats:italic>.<jats:italic>albicans<\/jats:italic>. We have previously characterized Ppg1, a PP2A-type protein phosphatase that controls filament extension and virulence in<jats:italic>C<\/jats:italic>.<jats:italic>albicans<\/jats:italic>. This study conducted RNA sequencing analysis of samples obtained from<jats:italic>C<\/jats:italic>.<jats:italic>albicans<\/jats:italic>wild type and<jats:italic>ppg1<\/jats:italic>\u0394<jats:italic>\/<\/jats:italic>\u0394 strains grown under filament-inducing conditions. Overall,<jats:italic>ppg1<\/jats:italic>\u0394<jats:italic>\/<\/jats:italic>\u0394 strain showed 1448 upregulated and 710 downregulated genes, representing approximately one-third of the entire annotated<jats:italic>C<\/jats:italic>.<jats:italic>albicans<\/jats:italic>genome. Transcriptomic analysis identified significant downregulation of well-characterized genes linked to filamentation and virulence, such as<jats:italic>ALS3<\/jats:italic>,<jats:italic>HWP1<\/jats:italic>,<jats:italic>ECE1<\/jats:italic>,<jats:italic>and RBT1<\/jats:italic>.<jats:italic>Expression analysis showed that essential<\/jats:italic>genes involved in<jats:italic>C<\/jats:italic>.<jats:italic>albicans<\/jats:italic>central carbon metabolisms, including<jats:italic>GDH3<\/jats:italic>,<jats:italic>GPD1<\/jats:italic>,<jats:italic>GPD2<\/jats:italic>,<jats:italic>RHR2<\/jats:italic>,<jats:italic>INO1<\/jats:italic>,<jats:italic>AAH1<\/jats:italic>, and<jats:italic>MET14<\/jats:italic>were among the top upregulated genes. Subsequent metabolomics analysis of<jats:italic>C<\/jats:italic>.<jats:italic>albicans ppg1<\/jats:italic>\u0394<jats:italic>\/<\/jats:italic>\u0394 strain revealed a negative enrichment of metabolites with carboxylic acid substituents and a positive enrichment of metabolites with pyranose substituents. Altogether, Ppg1<jats:italic>in vitro<\/jats:italic>analysis revealed a link between metabolites substituents and filament formation controlled by a phosphatase to regulate morphogenesis and virulence.<\/jats:p>","DOI":"10.1371\/journal.pone.0259588","type":"journal-article","created":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T18:34:01Z","timestamp":1638902041000},"page":"e0259588","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Candida albicans PPG1, a serine\/threonine phosphatase, plays a vital role in central carbon metabolisms under filament-inducing conditions: A multi-omics approach"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8855-5320","authenticated-orcid":true,"given":"Mohammad Tahseen","family":"A. L. 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