{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:55:06Z","timestamp":1778115306753,"version":"3.51.4"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T00:00:00Z","timestamp":1636416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004845","name":"Haramaya University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004845","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Induction of labor (IOL) is an essential intervention to reduce adverse maternal and neonatal outcomes. It is also improved pregnancy outcomes, especially in resource-limited countries, where maternal and perinatal mortality is unacceptably high. However, there is a scarcity of evidence regarding the outcome of induction of labor and its predictors in low-income countries like Sub-Saharan Africa. Therefore, this study was aimed at assessing the outcome of induction of labor and associated factors among mothers who underwent labor induction in public Hospitals of Harari Regional State, Estern Ethiopia.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>A facility-based cross-sectional study was conducted from 1 to 30 March, 2019 in Harari Regional State, Eastern Ethiopia. A total of 717 mothers who underwent induction of labor in public Hospitals of Harari Regional State, Eastern Ethiopia from January 2017 to December 2018 were enrolled in the study. Data were collected using a pretested structured questionnaire. The collected data were entered into Epi-data version 3.1 and exported to SPSS version 24 (IBM SPSS Statistics, 2016) for further analysis. A multivariable logistic regression analysis was performed to estimate the effects of each predictor variable on the outcome of induction of labor after controlling for potential confounders. Statistical significance was declared at p-value &lt;0.05.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Overall, the prevalence of success of induction of labor was 65% [95% CI (61.5, 68.5)]. Pre-eclampsia\/eclampsia was found to be the most common indication for induction of labor (46.70%) followed by pre-labor rupture of fetal membrane (33.5%). In the final model of multivariable analysis, predictors such as: maternal age &lt; 24 years old [AOR = 1.93, 95%CI(1.14, 3.26)], nulliparity[AOR = 0.34, 95%CI(0.19, 0.59)], unfavorable Bishop score [AOR = 0.06, 95%CI(0.03, 0.12)], intermediate Bishop score [AOR = 0.08, 95%CI(0.04, 0.14)], misoprostol only method [AOR = 2.29, 95%CI(1.01, 5.19)], nonreassuring fetal heart beat pattern [AOR = 0.14, 95%CI (0.07, 0.25)] and Birth weight 3500 grams and above[AOR = 0.32, 95% CI (0.17, 0.59)] were statistically associated with the successful outcome of induction of labor.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>The prevalence of successful of induction of labor was relatively low in this study area because only two-thirds of the mothers who underwent induction of labor had a successful of induction. Therefore, this result calls for all stakeholders to give more emphasis on locally available induction protocols and guidelines. In addition, pre-induction conditions must be taken into consideration to avoid unwanted effect of failed induction of labour.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0259723","type":"journal-article","created":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T18:49:08Z","timestamp":1636483748000},"page":"e0259723","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Outcome of induction and associated factors among induced labours in public Hospitals of Harari Regional State, Eastern Ethiopia: A two years\u2019 retrospective analysis"],"prefix":"10.1371","volume":"16","author":[{"given":"Yimer Mohammed","family":"Beshir","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6586-8906","authenticated-orcid":true,"given":"Mohammed Abdurke","family":"Kure","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gudina","family":"Egata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kedir Teji","family":"Roba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2021,11,9]]},"reference":[{"key":"pone.0259723.ref001","unstructured":"WHO, Recommendation to labor induction, Department of Reproductive Health and Research, World Health Organization, Avenue Appia 20, CH-1211 Geneva 27, Switzerland. 2011."},{"key":"pone.0259723.ref002","volume-title":"Williams obstetrics","author":"F. Cunningham","year":"2014"},{"issue":"2","key":"pone.0259723.ref003","doi-asserted-by":"crossref","first-page":"224","DOI":"10.3109\/14767058.2014.993965","article-title":"The indication for induction of labor impacts the risk of cesarean delivery","volume":"29","author":"I. Parkes","year":"2016","journal-title":"The Journal of Maternal-Fetal & Neonatal Medicine"},{"issue":"3","key":"pone.0259723.ref004","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1080\/01443615.2017.1361388","article-title":"Induction of labour: clinical predictive factors for success and failure","volume":"38","author":"L. Batinelli","year":"2018","journal-title":"Journal of Obstetrics and Gynaecology"},{"issue":"6","key":"pone.0259723.ref005","doi-asserted-by":"crossref","first-page":"e65612","DOI":"10.1371\/journal.pone.0065612","article-title":"Patterns and Outcomes of Induction of Labour in Africa and Asia: a secondary analysis of the WHO Global Survey on Maternal and Neonatal Health","volume":"8","author":"J.P. Vogel","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"pone.0259723.ref006","doi-asserted-by":"crossref","first-page":"123","DOI":"10.4314\/ejhs.v26i2.6","article-title":"Outcome of induction and associated factors among term and post-term mothers managed at Jimma University specialized hospital: a two years\u2019 retrospective analysis","volume":"26","author":"W. Girma","year":"2016","journal-title":"Ethiopian journal of health sciences"},{"issue":"253","key":"pone.0259723.ref007","article-title":"Prevalence of failed induction of labor and associated factors among women delivered in Hawassa public health facilities, Ethiopia, 2015","volume":"4","author":"B. Hurissa","year":"2015","journal-title":"J women\u2019s health care"},{"key":"pone.0259723.ref008","unstructured":"Hiluf, S., Assessment of Prevalence and Factors Affecting Success of Induction of Labour among Women Attended Induction in Army Referral and Teaching Hospital Addis Ababa Jun 2015. 2015, Addis Ababa University."},{"key":"pone.0259723.ref009","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/419621","article-title":"Obstetric outcome and significance of labour induction in a health resource poor setting","volume":"2014","author":"O.L. Lawani","year":"2014","journal-title":"Obstetrics and gynecology international"},{"issue":"1","key":"pone.0259723.ref010","doi-asserted-by":"crossref","first-page":"122. e1","DOI":"10.1016\/j.ajog.2017.11.556","article-title":"Defining failed induction of labor","volume":"218","author":"W.A. Grobman","year":"2018","journal-title":"American journal of obstetrics and gynecology"},{"issue":"6","key":"pone.0259723.ref011","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1053\/j.semperi.2015.07.013","article-title":"Failed induction of labor","volume":"39","author":"C. Schoen","year":"2015","journal-title":"Semin Perinatol"},{"issue":"2","key":"pone.0259723.ref012","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1097\/GRF.0000000000000031","article-title":"Global perspectives on elective induction of labor","volume":"57","author":"J.P. Vogel","year":"2014","journal-title":"Clinical obstetrics and gynecology"},{"issue":"2","key":"pone.0259723.ref013","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s13224-013-0486-z","article-title":"The risk factors for failure of labor induction: a cohort study","volume":"64","author":"E. Giugliano","year":"2014","journal-title":"The Journal of Obstetrics and Gynecology of India"},{"key":"pone.0259723.ref014","doi-asserted-by":"crossref","first-page":"S194","DOI":"10.1016\/j.ijgo.2007.09.011","article-title":"Misoprostol for induction of labor with a live fetus","volume":"99","author":"A. Weeks","year":"2007","journal-title":"International Journal of Gynecology & Obstetrics"},{"issue":"255","key":"pone.0259723.ref015","first-page":"2","article-title":"Induction of labor prevalence and associated factors for its outcome at Wolliso St. Luke Catholic Hospital, South West Shewa, Oromia","volume":"7","author":"Y. Abdulkadir","year":"2017","journal-title":"Intern Med"},{"issue":"2","key":"pone.0259723.ref016","doi-asserted-by":"crossref","first-page":"143","DOI":"10.4103\/0189-5117.192213","article-title":"Predictors of successful induction of labour at a tertiary obstetric service in Southwest Nigeria","volume":"33","author":"F.A. Bello","year":"2016","journal-title":"Tropical Journal of Obstetrics and Gynaecology"},{"issue":"1","key":"pone.0259723.ref017","doi-asserted-by":"crossref","first-page":"22","DOI":"10.7196\/sajog.675","article-title":"Induction of labour at a regional hospital in KwaZulu-Natal, South Africa","volume":"20","author":"B. Malende","year":"2014","journal-title":"South African Journal of Obstetrics and Gynaecology"},{"key":"pone.0259723.ref018","unstructured":"FMOH, MANAGEMENT PROTOCOL ON SELECTED OBSTETRICS TOPICS:Federal Democratic Republic of Ethiopia Ministry of Health. 2010."},{"issue":"4","key":"pone.0259723.ref019","first-page":"567","article-title":"Labor induction techniques: which is the best?","volume":"44","author":"C.A. Penfield","year":"2017","journal-title":"Obstetrics and Gynecology Clinics"},{"issue":"8","key":"pone.0259723.ref020","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1055\/s-0032-1331024","article-title":"The Bishop Score as a Predictor of Labor Induction Success: A Systematic Review","volume":"30","author":"D.G.E. Kolkman","year":"2013","journal-title":"American journal of perinatology"},{"issue":"1","key":"pone.0259723.ref021","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2393-14-350","article-title":"Effects of induction of labour versus expectant management in women with impending post-term pregnancies: the 41 week\u201342 week dilemma","volume":"14","author":"J.C. Kortekaas","year":"2014","journal-title":"BMC pregnancy and childbirth"},{"issue":"1","key":"pone.0259723.ref022","doi-asserted-by":"crossref","first-page":"91. e1","DOI":"10.1016\/j.ajog.2014.07.035","article-title":"Preterm induction of labor: predictors of vaginal delivery and labor curves","volume":"212","author":"M. Feghali","year":"2015","journal-title":"American journal of obstetrics and gynecology"},{"issue":"1","key":"pone.0259723.ref023","doi-asserted-by":"crossref","first-page":"21","DOI":"10.4103\/TJOG.TJOG_59_16","article-title":"Feto-maternal outcome of induced versus spontaneous labour in a Nigerian Tertiary Maternity Unit","volume":"34","author":"O.Y. Abisowo","year":"2017","journal-title":"Tropical Journal of Obstetrics and Gynaecology"},{"issue":"1","key":"pone.0259723.ref024","first-page":"13","article-title":"Prevalence and predictors of failure in labor induction among pregnant women delivered in Northern-Tanzania 2000\u20132015: A Registry-based Retrospective Cohort Study","volume":"30","author":"C.S. Tarimo","year":"2019","journal-title":"Tanzania Medical Journal"},{"key":"pone.0259723.ref025","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.ejogrb.2016.06.007","article-title":"Simplified Bishop score including parity predicts successful induction of labor","volume":"203","author":"J. Ivars","year":"2016","journal-title":"European Journal of Obstetrics & Gynecology and Reproductive Biology"},{"key":"pone.0259723.ref026","first-page":"1","article-title":"The Proportion of Failed Induction of Labour and Associated Factors among Women Undergoing Induction of Labour in Dessie Referral Hospital: Northeast Ethiopia a Cross-sectional Study","author":"T. Dilnessa","year":"2019","journal-title":"Asian Journal of Pregnancy and Childbirth"},{"key":"pone.0259723.ref027","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12884-020-02862-7","article-title":"Prevalence, outcomes and associated factors of labor induction among women delivered at public hospitals of MEKELLE town-(a hospital based cross sectional study)","volume":"20","author":"G.D. Lueth","year":"2020","journal-title":"BMC pregnancy and childbirth"},{"issue":"03","key":"pone.0259723.ref028","article-title":"Determinants of outcome of Induction of Labor in Four Teaching Hospitals in Addis Ababa, Ethiopia","volume":"58","author":"R.D. Gebreyohannes","year":"2020","journal-title":"Ethiopian Medical Journal"},{"issue":"12","key":"pone.0259723.ref029","doi-asserted-by":"crossref","first-page":"161","DOI":"10.5897\/IJNM2018.0303","article-title":"Success of labour induction institution based cross-sectional study Wolaita Sodo, South Ethiopia","volume":"10","author":"E.T. Bekru","year":"2018","journal-title":"International Journal of Nursing and Midwifery"},{"key":"pone.0259723.ref030","unstructured":"Federal Democratic Republic of Ethiopia, P.C.C., Summary and statistical report of the 2007 population and housing census: Population size by age and sex, in Addis Ababa: Population Census Policy. 2008."},{"issue":"3","key":"pone.0259723.ref031","first-page":"298","article-title":"Factors associated with successful induction of labor","volume":"33","author":"G.K. Al-Shaikh","year":"2012","journal-title":"Saudi Med J"},{"issue":"253","key":"pone.0259723.ref032","article-title":"Prevalence of failed induction of labor and associated factors among women delivered in Hawassa public health facilities, Ethiopia, 2015","volume":"4","author":"B.F. Hurissa","year":"2015","journal-title":"J women\u2019s health care"},{"issue":"8","key":"pone.0259723.ref033","doi-asserted-by":"crossref","first-page":"933","DOI":"10.4103\/0366-6999.229897","article-title":"Labor onset, oxytocin use, and epidural Anesthesia for vaginal birth after Cesarean section and associated effects on maternal and neonatal outcomes in a tertiary Hospital in China: A retrospective study","volume":"131","author":"S.-W. Wu","year":"2018","journal-title":"Chinese medical journal"},{"issue":"1","key":"pone.0259723.ref034","first-page":"6","article-title":"Factors associated with failed induction of labour in a secondary care hospital","volume":"62","author":"N.B. Khan","year":"2012","journal-title":"Journal of the Pakistan Medical Association: JPMA"},{"issue":"7","key":"pone.0259723.ref035","first-page":"651","article-title":"A Study of Outcome of Induction of Labor: Medical Versus Surgical","volume":"24","author":"P. Kaur","year":"2013","journal-title":"Indian Journal of Clinical Practice"},{"issue":"8","key":"pone.0259723.ref036","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.18203\/2320-6012.ijrms20150305","article-title":"Induction of labour at Jos University teaching, hospital, Jos, Nigeria:a four-year review","volume":"3","author":"TA Oyebode.","year":"2015","journal-title":"Int J Res Med Sci"},{"key":"pone.0259723.ref037","unstructured":"Admani, R., Predictors Of Successful Induction Of Labour In Post-term Pregnancies At Kenyatta National Hospital. 2014, University of Nairobi."},{"issue":"3","key":"pone.0259723.ref038","first-page":"234","article-title":"Misoprostol use for cervical ripening and induction of labour in a Nigerian teaching hospital","volume":"10","author":"B. Ekele","year":"2007","journal-title":"Nigerian journal of clinical practice"},{"key":"pone.0259723.ref039","unstructured":"Chirwa, M., Factors associated with failed induction of labour at the University Teaching Hospital, Lusaka. 2014, University of Zambia."},{"issue":"3","key":"pone.0259723.ref040","doi-asserted-by":"crossref","first-page":"262. e1","DOI":"10.1016\/j.ajog.2008.06.076","article-title":"Early-onset severe preeclampsia: induction of labor vs elective cesarean delivery and neonatal outcomes","volume":"199","author":"M.C. Alanis","year":"2008","journal-title":"American journal of obstetrics and gynecology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0259723","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T18:49:46Z","timestamp":1636483786000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0259723"}},"subtitle":[],"editor":[{"given":"Subash Chandra","family":"Gupta","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,11,9]]},"references-count":40,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,11,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0259723","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,9]]}}}