{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T15:01:06Z","timestamp":1777734066582,"version":"3.51.4"},"reference-count":53,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T00:00:00Z","timestamp":1636675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010067","name":"Gobierno de Arag\u00f3n","doi-asserted-by":"publisher","award":["B01_20R"],"award-info":[{"award-number":["B01_20R"]}],"id":[{"id":"10.13039\/501100010067","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\"><jats:title>Background<\/jats:title><jats:p>Clinical outcomes among COVID-19 patients vary greatly with age and underlying comorbidities. We aimed to determine the demographic and clinical factors, particularly baseline chronic conditions, associated with an increased risk of severity in COVID-19 patients from a population-based perspective and using data from electronic health records (EHR).<\/jats:p><\/jats:sec><jats:sec id=\"sec002\"><jats:title>Methods<\/jats:title><jats:p>Retrospective, observational study in an open cohort analyzing all 68,913 individuals (mean age 44.4 years, 53.2% women) with SARS-CoV-2 infection between 15 June and 19 December 2020 using exhaustive electronic health registries. Patients were followed for 30 days from inclusion or until the date of death within that period. We performed multivariate logistic regression to analyze the association between each chronic disease and severe infection, based on hospitalization and all-cause mortality.<\/jats:p><\/jats:sec><jats:sec id=\"sec003\"><jats:title>Results<\/jats:title><jats:p>5885 (8.5%) individuals showed severe infection and old age was the most influencing factor. Congestive heart failure (odds ratio -OR- men: 1.28, OR women: 1.39), diabetes (1.37, 1.24), chronic renal failure (1.31, 1.22) and obesity (1.21, 1.26) increased the likelihood of severe infection in both sexes. Chronic skin ulcers (1.32), acute cerebrovascular disease (1.34), chronic obstructive pulmonary disease (1.21), urinary incontinence (1.17) and neoplasms (1.26) in men, and infertility (1.87), obstructive sleep apnea (1.43), hepatic steatosis (1.43), rheumatoid arthritis (1.39) and menstrual disorders (1.18) in women were also associated with more severe outcomes.<\/jats:p><\/jats:sec><jats:sec id=\"sec004\"><jats:title>Conclusions<\/jats:title><jats:p>Age and specific cardiovascular and metabolic diseases increased the risk of severe SARS-CoV-2 infections in men and women, whereas the effects of certain comorbidities are sex specific. Future studies in different settings are encouraged to analyze which profiles of chronic patients are at higher risk of poor prognosis and should therefore be the targets of prevention and shielding strategies.<\/jats:p><\/jats:sec>","DOI":"10.1371\/journal.pone.0259822","type":"journal-article","created":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T18:25:27Z","timestamp":1636741527000},"page":"e0259822","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":42,"title":["Chronic diseases associated with increased likelihood of hospitalization and mortality in 68,913 COVID-19 confirmed cases in Spain: A population-based cohort study"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5440-1710","authenticated-orcid":true,"given":"Antonio","family":"Gimeno-Miguel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4812-4657","authenticated-orcid":true,"given":"Kevin","family":"Bliek-Bueno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"Poblador-Plou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon\u00e1s","family":"Carmona-P\u00edrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Poncel-Falc\u00f3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisca","family":"Gonz\u00e1lez-Rubio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6518-749X","authenticated-orcid":true,"given":"Ignatios","family":"Ioakeim-Skoufa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Pico-Soler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mercedes","family":"Aza-Pascual-Salcedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Prados-Torres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2928-6623","authenticated-orcid":true,"given":"Luis Andr\u00e9s","family":"Gimeno-Feliu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the PRECOVID Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2021,11,12]]},"reference":[{"key":"pone.0259822.ref001","unstructured":"World Health Organization. Coronavirus disease (COVID-19) Weekly Epidemiological Update. https:\/\/www.who.int\/emergencies\/diseases\/novel-coronavirus-2019\/situation-reports (accessed 22 June 2021)."},{"issue":"3","key":"pone.0259822.ref002","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41579-020-00459-7","article-title":"Characteristics of SARS-CoV-2 and COVID-19","volume":"19","author":"B Hu","year":"2020","journal-title":"Nat Rev Microbiol"},{"issue":"13","key":"pone.0259822.ref003","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1001\/jama.2020.2648","article-title":"Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China","volume":"323","author":"Z Wu","year":"2020","journal-title":"JAMA"},{"key":"pone.0259822.ref004","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2021\/6660930","article-title":"A Systematic Review and Meta-Analysis of Risk Factors Associated with Severity and Death in COVID-19 Patients","volume":"2021","author":"P Du","year":"2021","journal-title":"Can J Infect Dis Med Microbiol"},{"issue":"5","key":"pone.0259822.ref005","doi-asserted-by":"crossref","first-page":"e0250602","DOI":"10.1371\/journal.pone.0250602","article-title":"Clinical determinants of the severity of COVID-19: A systematic review and meta-analysis","volume":"16","author":"X Li","year":"2021","journal-title":"PLoS ONE"},{"issue":"9","key":"pone.0259822.ref006","doi-asserted-by":"crossref","first-page":"4526","DOI":"10.3390\/ijms22094526","article-title":"Effects of sars-cov-2 on cardiovascular system: The dual role of angiotensin-converting enzyme 2 (ace2) as the virus receptor and homeostasis regulator-review","volume":"22","author":"A Aleksova","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"8","key":"pone.0259822.ref007","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.3390\/jcm10081545","article-title":"Systemic Inflammation and COVID-19 Mortality in Patients with Major Noncommunicable Diseases: Chronic Coronary Syndromes, Diabetes and Obesity","volume":"10","author":"A-L Buicu","year":"2021","journal-title":"J Clin Med"},{"issue":"1","key":"pone.0259822.ref008","doi-asserted-by":"crossref","DOI":"10.1186\/s12879-021-05992-1","article-title":"Informing the public health response to COVID-19: a systematic review of risk factors for disease, severity, and mortality","volume":"21","author":"M Flook","year":"2021","journal-title":"BMC Infect Dis"},{"issue":"3","key":"pone.0259822.ref009","doi-asserted-by":"crossref","DOI":"10.23736\/S1973-9087.20.06660-5","article-title":"Functional outcome after inpatient rehabilitation in postintensive care unit COVID-19 patients: findings and clinical implications from a real-practice retrospective study","volume":"57","author":"C Curci","year":"2021","journal-title":"Eur J Phys Rehabil Med"},{"issue":"1","key":"pone.0259822.ref010","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-88130-w","article-title":"A systematic review and meta-analysis of geographic differences in comorbidities and associated severity and mortality among individuals with COVID-19","volume":"11","author":"B Thakur","year":"2021","journal-title":"Sci Rep"},{"issue":"14","key":"pone.0259822.ref011","doi-asserted-by":"crossref","first-page":"5171","DOI":"10.3390\/ijerph17145171","article-title":"Baseline chronic comorbidity and mortality in laboratory-confirmed COVID-19 cases: Results from the PRECOVID study in Spain","volume":"17","author":"B Poblador-Plou","year":"2020","journal-title":"Int J Environ Res Public Health"},{"issue":"5","key":"pone.0259822.ref012","doi-asserted-by":"crossref","first-page":"5069","DOI":"10.21037\/apm-20-2557","article-title":"Risk factors for mortality of coronavirus disease 2019 (COVID-19) patients during the early outbreak of COVID-19: a systematic review and meta-analysis","volume":"10","author":"Y Wu","year":"2021","journal-title":"Ann Palliat Med"},{"key":"pone.0259822.ref013","unstructured":"Anc\u00edn Ducay JM, Erce L\u00f3pez S, Extramiana Cameno E, Izcue Argando\u00f1a A. Correlaci\u00f3n de C\u00f3digos CIE-9-MC (8a Edic.)\u2014CIAP-2 Para la Gesti\u00f3n de Incapacidad Temporal, 8th ed.; Instituto de Salud P\u00fablica y Laboral de Navarra: Pamplona, Spain. 2014. http:\/\/www.navarra.es\/NR\/rdonlyres\/E520399C-0612-4C75-A912-B16295014FC3\/281429\/codigosCIE_9_MC1.pdf (accessed on 26 May 2021)."},{"key":"pone.0259822.ref014","unstructured":"Elixhauser A, Steiner C, Palmer L. Clinical Classifications Software (CCS), 2009. Agency for Healthcare Research and Quality. http:\/\/www.hcup-us.ahrq.gov\/toolssoftware\/ccs\/ccs.jsp (accessed on 15 August 2012)."},{"key":"pone.0259822.ref015","unstructured":"Chronic Condition Indicator (CCI) for ICD-9-CM. https:\/\/www.hcup-us.ahrq.gov\/toolssoftware\/chronic\/chronic.jsp (accessed on 23 May 2021)."},{"issue":"9","key":"pone.0259822.ref016","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1003321","article-title":"Comorbidities associated with mortality in 31,461 adults with COVID-19 in the United States: A federated electronic medical record analysis","volume":"17","author":"SL Harrison","year":"2020","journal-title":"PLoS Med"},{"issue":"1","key":"pone.0259822.ref017","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41371-020-0387-4","article-title":"Covid-19 and the cardiovascular system: a comprehensive review","volume":"35","author":"RB Azevedo","year":"2020","journal-title":"J Hum Hypertens"},{"issue":"2","key":"pone.0259822.ref018","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/all.14657","article-title":"Risk factors for severe and critically ill COVID-19 patients","volume":"76","author":"Gao Y dong","year":"2020","journal-title":"A review. Allergy"},{"issue":"4","key":"pone.0259822.ref019","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.dsx.2020.04.018","article-title":"Diabetes mellitus is associated with increased mortality and severity of disease in COVID-19 pneumonia\u2014A systematic review, meta-analysis, and meta-regression: Diabetes and COVID-19","volume":"14","author":"I Huang","year":"2020","journal-title":"Diabetes Metab Syndr Clin Res Rev"},{"issue":"3","key":"pone.0259822.ref020","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1002\/jmv.26424","article-title":"Epidemiology of COVID-19: A systematic review and meta-analysis of clinical characteristics, risk factors, and outcomes","volume":"93","author":"J Li","year":"2020","journal-title":"J Med Virol"},{"issue":"8","key":"pone.0259822.ref021","doi-asserted-by":"crossref","DOI":"10.1016\/j.jstrokecerebrovasdis.2020.104949","article-title":"Impact of cerebrovascular and cardiovascular diseases on mortality and severity of COVID-19\u2013systematic review, meta-analysis, and meta-regression","volume":"29","author":"R Pranata","year":"2020","journal-title":"J Stroke Cerebrovasc Dis"},{"issue":"1","key":"pone.0259822.ref022","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ajic.2020.06.008","article-title":"Meta-analysis investigating the relationship between clinical features, outcomes, and severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia","volume":"49","author":"J Li","year":"2021","journal-title":"Am J Infect Control"},{"issue":"2","key":"pone.0259822.ref023","doi-asserted-by":"crossref","first-page":"e16","DOI":"10.1016\/j.jinf.2020.04.021","article-title":"Risk factors of critical & mortal COVID-19 cases: A systematic literature review and meta-analysis","volume":"81","author":"Z Zheng","year":"2020","journal-title":"J Infect"},{"key":"pone.0259822.ref024","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ijid.2020.03.017","article-title":"Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis","volume":"94","author":"J Yang","year":"2020","journal-title":"Int J Infect Dis"},{"issue":"23","key":"pone.0259822.ref025","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1182\/blood.2020006000","article-title":"COVID-19 and its implications for thrombosis and anticoagulation","volume":"135","author":"J Connors","year":"2020","journal-title":"Blood"},{"issue":"5","key":"pone.0259822.ref026","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1111\/jth.14817","article-title":"Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy","volume":"18","author":"N Tang","year":"2020","journal-title":"J Thromb Haemost"},{"issue":"3","key":"pone.0259822.ref027","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.rbmo.2020.06.013","article-title":"Assisted reproduction and thromboembolic risk in the COVID-19 pandemic","volume":"41","author":"F Fabregues","year":"2020","journal-title":"Reprod Biomed Online"},{"issue":"5","key":"pone.0259822.ref028","doi-asserted-by":"crossref","DOI":"10.1152\/ajpheart.00217.2020","article-title":"COVID-19, ACE2, and the cardiovascular consequences","volume":"318","author":"AM South","year":"2020","journal-title":"Am J Physiol Circ Physiol"},{"issue":"5","key":"pone.0259822.ref029","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1111\/jth.14810","article-title":"ISTH interim guidance on recognition and management of coagulopathy in COVID-19","volume":"18","author":"J Thachil","year":"2020","journal-title":"J Thromb Haemost"},{"issue":"7","key":"pone.0259822.ref030","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1161\/CIRCRESAHA.121.318054","article-title":"Hypertension, a Moving Target in COVID-19","volume":"128","author":"C Savoia","year":"2021","journal-title":"Circ Res"},{"issue":"1","key":"pone.0259822.ref031","doi-asserted-by":"crossref","DOI":"10.1186\/s40885-021-00161-7","article-title":"Should all patients with hypertension be worried about developing severe coronavirus disease 2019 (COVID-19)?","volume":"27","author":"R Hosseinzadeh","year":"2021","journal-title":"Clin Hypertens"},{"issue":"1","key":"pone.0259822.ref032","article-title":"Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues","volume":"9","author":"MY Li","year":"2020","journal-title":"Infect Dis Poverty"},{"issue":"6","key":"pone.0259822.ref033","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1111\/resp.14049","article-title":"Effect of comorbid pulmonary disease on the severity of COVID-19: A systematic review and meta-analysis","volume":"26","author":"A G\u00fclsen","year":"2021","journal-title":"Respirology"},{"issue":"10","key":"pone.0259822.ref034","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1002\/jmv.25889","article-title":"The impact of COPD and smoking history on the severity of COVID-19: A systemic review and meta-analysis","volume":"92","author":"Q Zhao","year":"2020","journal-title":"J Med Virol"},{"key":"pone.0259822.ref035","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.sleep.2021.03.029","article-title":"Obstructive sleep apnea (OSA) and outcomes from coronavirus disease 2019 (COVID-19) pneumonia: a systematic review and meta-analysis","volume":"82","author":"TI Hariyanto","year":"2021","journal-title":"Sleep Med"},{"issue":"2","key":"pone.0259822.ref036","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1007\/s11325-020-02203-0","article-title":"Obstructive Sleep Apnea and Risk of COVID-19 Infection, Hospitalization and Respiratory Failure","volume":"25","author":"MB Maas","year":"2021","journal-title":"Sleep Breath"},{"issue":"1","key":"pone.0259822.ref037","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s11239-007-0157-y","article-title":"Chronic obstructive pulmonary disease and deep vein thrombosis: A prevalent combination","volume":"26","author":"R Shetty","year":"2007","journal-title":"J Thromb Thrombolysis"},{"issue":"2","key":"pone.0259822.ref038","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.thromres.2014.06.009","article-title":"Association between obstructive sleep apnea and deep vein thrombosis \/ pulmonary embolism: A population-based retrospective cohort study","volume":"134","author":"YH Peng","year":"2014","journal-title":"Thromb Res"},{"issue":"1","key":"pone.0259822.ref039","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00408-012-9427-3","article-title":"Obstructive sleep apnea syndrome: Blood viscosity, blood coagulation abnormalities, and early atherosclerosis","volume":"191","author":"DM Toraldo","year":"2012","journal-title":"Lung"},{"issue":"4","key":"pone.0259822.ref040","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s10654-010-9435-7","article-title":"Chronic obstructive pulmonary disease and the risk of cardiovascular diseases","volume":"25","author":"C Schneider","year":"2010","journal-title":"Eur J Epidemiol"},{"issue":"1","key":"pone.0259822.ref041","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.apmr.2020.09.376","article-title":"Neuropsychological Features of Severe Hospitalized Coronavirus Disease 2019 Patients at Clinical Stability and Clues for Postacute Rehabilitation","volume":"102","author":"F Negrini","year":"2021","journal-title":"Arch Phys Med Rehabil"},{"issue":"4","key":"pone.0259822.ref042","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.3233\/JAD-200937","article-title":"Cognitive Impairment Is a Common Comorbidity in Deceased COVID-19 Patients: A Hospital-Based Retrospective Cohort Study","volume":"78","author":"P Mart\u00edn-Jim\u00e9nez","year":"2020","journal-title":"J Alzheimers Dis"},{"issue":"2","key":"pone.0259822.ref043","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.dld.2020.09.007","article-title":"Metabolic associated fatty liver disease increases the severity of COVID-19: A meta-analysis","volume":"53","author":"L Pan","year":"2021","journal-title":"Dig Liver Dis"},{"issue":"2","key":"pone.0259822.ref044","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/s41584-020-00562-2","article-title":"Rheumatic disease and COVID-19: epidemiology and outcomes","volume":"17","author":"KL Hyrich","year":"2021","journal-title":"Nat Rev Rheumatol"},{"issue":"9","key":"pone.0259822.ref045","doi-asserted-by":"crossref","first-page":"e549","DOI":"10.1016\/S2665-9913(20)30169-7","article-title":"COVID-19 in patients with rheumatic diseases in northern Italy: a single-centre observational and case\u2013control study","volume":"2","author":"M Fredi","year":"2020","journal-title":"Lancet Rheumatol"},{"key":"pone.0259822.ref046","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2020.00565","article-title":"Outcomes of Patients With Hypothyroidism and COVID-19: A Retrospective Cohort Study","volume":"11","author":"M van Gerwen","year":"2020","journal-title":"Front Endocrinol"},{"issue":"2","key":"pone.0259822.ref047","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1530\/EJE-10-0695","article-title":"Association between thyroid function tests at baseline and the outcome of patients with sepsis or septic shock: A systematic review","volume":"164","author":"AG Angelousi","year":"2011","journal-title":"Eur J Endocrinol"},{"issue":"11","key":"pone.0259822.ref048","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1111\/imj.15000","article-title":"Possible role of hypothyroidism in the prognosis of COVID-19","volume":"50","author":"M Daraei","year":"2020","journal-title":"Intern Med J"},{"issue":"7","key":"pone.0259822.ref049","doi-asserted-by":"crossref","first-page":"102575","DOI":"10.1016\/j.autrev.2020.102575","article-title":"SARS-CoV-2 infection among patients with systemic autoimmune diseases","volume":"19","author":"G Emmi","year":"2020","journal-title":"Autoimmun Rev"},{"key":"pone.0259822.ref050","article-title":"Risk of COVID-19 in Rheumatoid Arthritis: A National Veterans Affairs Matched Cohort Study in At-Risk Individuals","author":"BR England","year":"2021","journal-title":"Arthritis Rheumatol"},{"issue":"12","key":"pone.0259822.ref051","doi-asserted-by":"crossref","first-page":"e1021","DOI":"10.1093\/cid\/ciaa1793","article-title":"Coronavirus Disease 2019 (COVID-19) Infection Among People With Human Immunodeficiency Virus in New York City: A Population-Level Analysis of Linked Surveillance Data","volume":"72","author":"SL Braunstein","year":"2020","journal-title":"Clin Infect Dis"},{"issue":"12","key":"pone.0259822.ref052","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1097\/QAD.0000000000002643","article-title":"Clinical characteristics, risk factors, and incidence of symptomatic coronavirus disease 2019 in a large cohort of adults living with HIV: a single-center, prospective observational study","volume":"34","author":"A Inciarte","year":"2020","journal-title":"AIDS"},{"issue":"7","key":"pone.0259822.ref053","doi-asserted-by":"crossref","first-page":"536","DOI":"10.7326\/M20-3689","article-title":"Incidence and Severity of COVID-19 in HIV-Positive Persons Receiving Antiretroviral Therapy: A Cohort Study","volume":"173","author":"J Del Amo","year":"2020","journal-title":"Ann Intern Med"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0259822","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T15:28:27Z","timestamp":1699802907000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0259822"}},"subtitle":[],"editor":[{"given":"Alessandro","family":"de Sire","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,11,12]]},"references-count":53,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,11,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0259822","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,12]]}}}